2011
DOI: 10.1002/jbm.b.31801
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A pH‐sensitive chitosan‐tripolyphosphate hydrogel beads for controlled glipizide delivery

Abstract: A chitosan(CS)-tripolyphosphate (TPP) hydrogel bead was prepared by the ionic gelation method for the controlled delivery of glipizide. The structure and surface morphology of the beads were characterized by FT-IR and SEM, separately. Factors influencing the swelling behavior of the hydrogel beads were also investigated, such as CS concentration (X(1)), TPP concentration (X(2)), the weight ratio of drug to polymer (X(3)), crosslinking time (X(4)), and the volume ratio of CS to TPP (X(5)). In addition, the swel… Show more

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Cited by 56 publications
(19 citation statements)
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“…In this method, an anionic cross-linking agent is introduced into an aqueous solution of CS in acetic acid. The cross-linking structure of the CS/TPP system is mainly determined by the reaction between the amino groups of CS and TPP ions, and this reaction depends strongly on the associated pH [15,16]. Alteration in the parameters such as cross-linker concentration, drug/polymer ratio, and processing conditions affects the morphology of CSNPs and the release rate of the loaded drug [17,18].…”
Section: Introductionmentioning
confidence: 99%
“…In this method, an anionic cross-linking agent is introduced into an aqueous solution of CS in acetic acid. The cross-linking structure of the CS/TPP system is mainly determined by the reaction between the amino groups of CS and TPP ions, and this reaction depends strongly on the associated pH [15,16]. Alteration in the parameters such as cross-linker concentration, drug/polymer ratio, and processing conditions affects the morphology of CSNPs and the release rate of the loaded drug [17,18].…”
Section: Introductionmentioning
confidence: 99%
“…It is a simple and cheap process and has the advantage of avoiding the use of organic solvents (Shu and Zhu 2002). Sun et al (2011) studied the influence of chitosan and pentasodium tripolyphosphate concentration, the weight ratio between a drug (glizipide) and the polymer, crosslinking time, the volume ratio of chitosan to pentasodium tripolyphosphate and pH for the production of chitosan and pentasodium tripolyphosphate hydrogel beads loading glizipide. The results clearly suggested the chitosan hydrogel beads could be developed as a pH-sensitive controlled release system for the delivery of glipizide.…”
Section: Introductionmentioning
confidence: 99%
“…Modified chitosan hydrogels have been proven to be a potential carrier for delivery of different drug molecules with respect to size and type [6][7][8] . As few reports were found on modified chitosan hydrogel, this review summarizes recent developments in its properties and applications.…”
Section: Introductionmentioning
confidence: 99%