A pH-sensitive semi-interpenetrating polymer network hydrogels constructed by konjac glucomannan and poly (γ-glutamic acid): Synthesis, characterization and swelling behavior

Zhu, Chongyang; Tang, Ning; Gan, Jing; Zhang, Xiaojun; Li, Yang; Jia, Xin; Cheng, Yongqiang

doi:10.1016/j.ijbiomac.2021.06.046

Cited by 33 publications

(8 citation statements)

References 46 publications

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“…Percent of the drug released is also influenced by the different concentrations of GA, AAc, and EGDMA at both pH 1.2 and 7.4, respectively, as indicated in Figure 7 C–E. The percent of the drug released increases as the concentration of GA and AAc increases ( Figure 7 C,D), because a greater quantity of carboxylic groups (COOH) is produced, leading to higher swelling and a percent of the drug released [ 56 , 57 , 58 ]. Similar to swelling, a reduction in the percent of the drug released is seen as the concentration of the EGDMA is increased ( Figure 7 E) due to higher crosslinking and bulk density and less porosity [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier

et al. 2021

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Glutamic acid-co-poly(acrylic acid) (GAcPAAc) hydrogels were prepared by the free radical polymerization technique using glutamic acid (GA) as a polymer, acrylic acid (AAc) as a monomer, ethylene glycol dimethylacrylate (EGDMA) as a cross-linker, and ammonium persulfate (APS) as an initiator. Increase in gel fraction was observed with the increasing concentration of glutamic acid, acrylic acid, and ethylene glycol dimethylacrylate. High percent porosity was indicated by developed hydrogels with the increase in the concentration of glutamic acid and acrylic acid, while a decrease was seen with the increasing concentration of EGDMA, respectively. Maximum swelling and drug release was exhibited at high pH 7.4 compared to low pH 1.2 by the newly synthesized hydrogels. Similarly, both swelling and drug release increased with the increasing concentration of glutamic acid and acrylic acid and decreased with the increase in ethylene glycol dimethylacrylate concentration. The drug release was considered as non-Fickian transport and partially controlled by viscoelastic relaxation of hydrogel. In-vivo study revealed that the AUC0–∞ of fabricated hydrogels significantly increased compared to the drug solution and commercial product Keten. Hence, the results indicated that the developed hydrogels could be used as a suitable carrier for controlled drug delivery.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier

et al. 2021

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“…The swelling ratios of Pdmda 1 and Pdmda 2 were highest in an acidic medium but lowest in a neutral medium, and it was highest in an alkaline medium and lowest in a neutral medium for Pdmda 3 and Pdmda 4 , while it was highest in an alkaline medium and lowest in an acidic medium for Pdmda 5 . These results suggested that the swelling behavior of the prepared PDMDA hydrogels exhibited pH sensitivity and component dependence, which was mainly attributed to the different ionizable groups of the different units on the polymer chains 48,49 (Figure S8).…”

Section: Anisotropic Swelling Propertiesmentioning

confidence: 94%

Oxygen-co-Thermal Driver for Constructing Integrated Anisotropic Hydrogels with Programmable Shape Deformation, Superior Self-Healing, and Mechanical Performance

Ye,

Yong,

et al. 2023

Chem. Mater.

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Gradient hydrogels hold great potential for applications in actuators due to their unique stimulus response performance and simple integrated structure. However, most of the currently available gradient structure programming strategies are dependent on complex external fields and employ a single structural driving force, which limits their further development. In this study, we proposed a novel oxygen-co-thermal driving structure programming strategy for constructing the integrated anisotropic bistructured hydrogels with multifunctionality. Namely, we utilized the simple and low-cost oxygen gradient dissolution behavior and heat transfer behavior in nature as the dual driving force of the gradient structure, combined with the spontaneous existence of electrostatic attraction between polyelectrolyte chains, to construct integrated hydrogels with both gradient and phase separation structures in a one-step method. It was shown that the designed hydrogels exhibited remarkable self-healing ability and mechanical property. Moreover, the hydrogel exhibited superior responsive deformation capability, and the deformation behavior was programmable depending on internal conditions (composition ratio and specific surface area) and external stimuli (pH and temperature). In addition, the successful construction of humidity alarms and grippers by the designed hydrogel demonstrated that our study provides new insights into the field of manufacturing smart actuators.

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“…About one acetyl group in every 17–19 sugar units is located at the C-6 position, which contributes to the solubility and gel properties of KGM . KGM could only be degraded by colonic bacterial enzymes, so it is able to a targeted controlled release carrier. , KGM can undergo oxidation reaction with sodium periodate to generate reactive aldehyde functional groups and further obtain oxidized KGM . A recent study also reported that sulfhydryl-oxidized KGM hydrogel microspheres as a delivery system for probiotics could significantly increase their survival in simulated gastric juice .…”

Section: Origin and Properties Of Polysaccharide Hydrogelsmentioning

confidence: 99%

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Zhang

Dong

Liu

et al. 2022

J. Agric. Food Chem.

108

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Hydrogels obtained from natural polymers have received widespread attention for their excellent biocompatible property, nontoxicity, easy gelation, and functionalization. Polysaccharides can regulate the gut microbiota and improve the intestinal microenvironment, thus exerting the healthy effect of intestinal immunity. In an active substance delivery system, the extent and speed of the substance reaching its target are highly dependent on the carrier. Thus, the smart active substance delivery systems are gradually increasing. The smart polysaccharide-hydrogels possess the ability in response to external stimuli through changing their volume phase and structure, which are applied in various fields. Natural polysaccharide-based hydrogels possess excellent characteristics of environmental friendliness, good biocompatibility, and abundant sources. According to the response type, natural polysaccharide-based hydrogels are usually divided into stimulus-responsive hydrogels, including internal response (pH, temperature, enzyme, redox) and external response (light, electricity, magnetism) hydrogels. The delivery system based on polysaccharides can exert their effects in the gastrointestinal tract. At the same time, polysaccharides may also take part in regulating the brain signals through the microbiota-gut-brain axis. Therefore, natural polysaccharide-hydrogels are considered as promising biomaterials, which can be designed as delivery systems for regulating the gut-brain axis. This article reviews the research advance of stimulus-responsive hydrogels, which focus on the types, response characteristics, and applications for polysaccharide-based smart hydrogels as delivery systems.

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A pH-sensitive semi-interpenetrating polymer network hydrogels constructed by konjac glucomannan and poly (γ-glutamic acid): Synthesis, characterization and swelling behavior

Cited by 33 publications

References 46 publications

Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier

Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier

Oxygen-co-Thermal Driver for Constructing Integrated Anisotropic Hydrogels with Programmable Shape Deformation, Superior Self-Healing, and Mechanical Performance

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

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