A pH-sensitive, stimuli-responsive, superabsorbent, smart hydrogel from psyllium (<i>Plantago ovata</i>) for intelligent drug delivery

Irfan, Jaffar; Hussain, Muhammad Ajaz; Haseeb, Muhammad Tahir; Ali, Arshad; Farid-ul-Haq, Muhammad; Tabassum, Tahira; Hussain, Syed Zajif; Hussain, Irshad; Naeem-ul-Hassan, Muhammad

doi:10.1039/d1ra02219a

Cited by 22 publications

(4 citation statements)

References 52 publications

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“…The absorption band at 1612 cm −1 in unmodified ALH disappears in CL-ALH as the ester carbonyl signals, due to the successful crosslinking of ALH with CA, appeared at 1728 cm −1 . 32 The signals of the polymeric backbone of CL-ALH appeared at 2901 cm −1 is due to –CH 2 symmetric and –CH stretching vibration whereas the hydroxyl signals in CL-ALH appeared at 3551 cm −1 . The stretching vibrations of ether linkage (C–O–C) in ALH spectrum 32 were shifted from 1047 cm −1 towards a higher wavenumber, 1081 cm −1 after cross-linking as shown in the FTIR spectrum of CL-ALH (Fig.…”

Section: Resultsmentioning

confidence: 96%

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Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery

Irfan,

Ali,

Hussain

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 96%

“…Whereas, the literature has indicated the presence of signals at 105.56 ppm for C1 and 63.24 to 79.33 ppm for C2-6 for unmodified ALH. 32 The upfield shifting in all signals of ALH after crosslinking with CA, especially the carbonyl region indicated the formation of ester bonds between ALH and CA.…”

Section: Resultsmentioning

confidence: 97%

Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery

Irfan,

Ali,

Hussain

et al. 2024

RSC Adv.

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“…Interestingly, Hussain et al isolated polysaccharide-based stimuli-responsive hydrogel from arabinoxylan, basil seed, linseed, , Salvia spinosa seeds, and glucuronoxylan ,, for distinctive drug delivery. Primarily, these hydrogels do not utilize any chemical cross-linking agents for fabrication.…”

Section: Hydrogel Cross-linking Methodsmentioning

confidence: 99%

“…130 Additionally, Li et al reported phenylboronic modified chitosan and oxidized dextran hydrogel that were able to undergo covalent cross-linking through imine bond and phenylboronate ester for pH and glucose-responsive drug delivery. 131 Interestingly, Hussain et al isolated polysaccharide-based stimuli-responsive hydrogel from arabinoxylan, 20 basil seed, 21 linseed, 132,133 Salvia spinosa seeds, 134 and glucuronoxylan 33,135,136 for distinctive drug delivery. Primarily, these hydrogels do not utilize any chemical cross-linking agents for fabrication.…”

Section: Click Chemistrymentioning

confidence: 99%

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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Hydrogels are a soft material that undergoes cross-linking between polymers to form a hydrophilic three-dimensional network. In fact, similarity to body tissue, soft consistency, biocompatibility, and elasticity, impart a protagonic role of hydrogel to be applied as a biomaterial. In response to external cues, stimuli-responsive hydrogels are particularly impactful, enabling remarkable levels of control over material properties. They can endure changes in swelling behavior, permeability, network structure, and mechanical strength. Nevertheless, such changes induce single-cycle or reversible transitions, so hydrogels can regain their initial state once the trigger is removed. Recently, polysaccharide-based hydrogels with stimuli-responsive properties resulted in developing biomimetic structures for a widespread biotechnological application owing to their excellent biodegradability, biocompatibility, nonimmunogenicity, functional properties, ease of gelation, and derivatization. This review will initially highlight recent advances in cross-linking methods and chemistry for preparing stimuli-responsive hydrogels. Subsequently, state-of-the-art techniques to understand the structural, chemical, and rheological behavior of polysaccharide-based stimuli-responsive hydrogel will be discussed. Additionally, the responsiveness of polysaccharide hydrogel toward diverse stimuli such as redox, temperature, light, pH, magnetism, electricity, etc., with a broad spectrum of applications will be described in detail. This review also attempts to address the lacunae of existing stimuli-responsive hydrogel and their future perspectives.

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Removal of copper and cobalt ions from aqueous solutions using starch‐xanthate based novel smart hydrogel via adsorption technique: Swelling, adsorption isotherm, and kinetic study

Chaurasiya,

Pande,

Shankar

et al. 2024

J of Applied Polymer Sci

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The concentration of harmful metal ions is growing globally, which raises the risk to both human and ecological health. The use of “adsorption” technique has been found to be very effective, for the removal of toxic metal ions. Among other things, hydrogels as an adsorbent work effectively for the removal of toxic metal ions and other aquatic pollutants. The newly designed potato starch‐xanthate (SX) based hydrogel (SX‐modified hydrogel) has been synthesized using a mixture of acrylamide (AAm) and acrylic acid (AA) monomers, with the help of free‐radical graft copolymerization technique. The synthesized SX‐modified hydrogel has been characterized by several analytical techniques, namely, UV–visible (UV–vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, gel permeation chromatography (GPC), thermogravimetric (TG) analysis, point of zero charge (ΔpHPZC) analysis, x‐ray diffraction (XRD) analysis, and scanning electron microscope (SEM) analysis. The main objective of the current work is to remove the Cu2+ and Co2+ ions from wastewater using SX‐modified hydrogel as well as to study the swelling and water retention properties of the SX‐modified hydrogel. The swelling ratio of SX‐modified hydrogel has been found to be 312.31, 374.01, and 410.20 g/g at optimum pH 10, temperature 35°C, time 675 min in gray wastewater, tap water, and distilled water, respectively. The maximum percentage removal of Cu2+ and Co2+ ions by SX‐modified hydrogel has been found as 97.7% and 94.2%, respectively, at optimum conditions. The Langmuir isotherm model fits best with the experimental data, with maximum adsorption capacity of 515.46 mg/g for Cu2+ and 483.09 mg/g for Co2+ ions, respectively. The kinetic studies suggest that the adsorption process is governed by the second order kinetic model with rate constant of 2.06 × 10−4 g/(mg min) for Cu2+ and 1.79 × 10−4 g/(mg min) for Co2+ ions, respectively. The negative ΔG values suggest the adsorption process is spontaneous in nature. In addition, the positive ΔH values support the adsorption process is endothermic in nature. The SX‐modified hydrogel showed a remarkable desorption efficiency with 96.7% for Cu2+ and 92.5% for Co2+ ions and reusability for four consecutive adsorption–desorption cycles. It can be concluded that the SX‐modified hydrogel has showed an effective, economical, easy, low energy consuming, and significant potential in the treatment of wastewater containing heavy metal ions.

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A pH-sensitive, stimuli-responsive, superabsorbent, smart hydrogel from psyllium (Plantago ovata) for intelligent drug delivery

Abstract: Herein, we report the dynamic swelling, stimuli responsive swelling-deswelling properties, sub-acute toxicity studies and sustained drug release potential of a polysaccharide-based hydrogel isolated from psyllium husk (a well-known dietary fiber).

Cited by 22 publications

References 52 publications

Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery

Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Removal of copper and cobalt ions from aqueous solutions using starch‐xanthate based novel smart hydrogel via adsorption technique: Swelling, adsorption isotherm, and kinetic study

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