A pH tuning single fluorescent probe based on naphthalene for dual-analytes (Mg²⁺ and Al³⁺) and its application in cell imaging

Abstract

In this study, a naphthalene Schiff-base P which serves as a dual-analyte probe for the quantitative detection of Al3+ and Mg2+ has been designed.

Study of a Fluorescent System Based on the Naphthalene Derivative Fluorescent Probe Bound to Al3+

“…The washing was halted, and a yellow-brown solid compound was produced by drying it at 45 • C in a vacuum drying oven. The resulting chemical was known as 3 [25,26].…”

Characterization of a Hg2+-Selective Fluorescent Probe Based on Rhodamine B and Its Imaging in Living Cells

“…However, these reported rhodamine-based Hg 2+ -selective fluorescent probes still have shortcomings that need to be overcome, such as cross-sensitivities toward other metal ions and anions [ 27 ], pH dependency [ 28 ], and non-suitability for cell imaging [ 22 , 23 ], which could lower the sensitivity and limit the practical application of probes in environmentally and biologically relative targets. Compared with some successful fluorescence “turn-on” probes for imaging intracellular metal ions, such as Cu 2+ [ 29 ], Al 3+ [ 30 ], and Mg 2+ [ 31 ], the development of highly selective, sensitive, and cell membrane-penetrable Hg 2+ fluorescent probes with “off–on” signals is still a bottleneck. Therefore, ”off–on” fluorescent probes for Hg 2+ based on rhodamine derivatives in environmental water samples and living cells are still a very active and significant challenge now and in the future.…”

Synthesis and Characterization of a Mg2+-Selective Probe Based on Benzoyl Hydrazine Derivative and Its Application in Cell Imaging

“…Many biologically important targets, including metal ions, anions, and amino acids have been successfully detected by fluorescence techniques in vitro and in vivo because of the significant advantages such as the non-destructive characteristic, fast response, and good sensitivity compared with other common detection methods [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Among the bioavailable species, Mg 2+ is the most abundant divalent cation in living cells and plays important roles in many cellular processes, such as DNA synthesis and protein phosphorylation.…”

“…Among the bioavailable species, Mg 2+ is the most abundant divalent cation in living cells and plays important roles in many cellular processes, such as DNA synthesis and protein phosphorylation. It also has been involved in many cardiovascular and neurological processes in human body [ 6 , 8 ]. The disorder of concentrations of Mg 2+ would cause the pathogenesis of many diseases, such as diabetes, hypertension, epilepsy, and Alzheimers [ 9 , 10 ].…”