A Pharmacokinetic Model for Intraperitoneal Administration of Drugs: Application to Teniposide in Humans

Canal, Pierre; Plusquellec, Y.; Chatelut, Étienne; Bugat, R.; Biasi, J. De; Houin, Georges

doi:10.1002/jps.2600780509

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…Nevertheless, since the peritoneum provides for a large surface area for absorption, systemic absorption may be quite rapid and relatively complete following i.p. vs oral drug administration, a ¼nding that may have contributed to the ¼ndings noted in the present study (Lukas et al, 1971;Canal et al, 1989). It is posited that increased rate of tissue accumulation and bioavailability of chloroquine demonstrated by i.p.…”

Section: Discussionmentioning

confidence: 64%

Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection

Gaynes

Torczynski

Varro

et al. 2008

J of Applied Toxicology

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Chloroquine is quinolone derivative known to exert dose-related retinal toxicity, albeit in a variable manner. It is thought that variability in the presentation of chloroquine retinopathy may be the result of perturbations in drug bioavailability subsequent to oral ingestion. In order to better understand the ramifications of bioavailability on the development of retinal injury subsequent to chloroquine use, this study investigated the relationship between retinal injury and chloroquine administration via intraperitoneal rather than oral administration. Four-week-old C57/6J mice underwent daily intraperitoneal injection of 10 mg kg(-1) chloroquine hydrochloride for a total of 62 days. Following treatment, tissue was fixed in preparation for analysis by light and transmission electron microscopy. Treated animals demonstrated marked abnormality of the outer retinal layers described as complete loss of the outer plexiform layer as well as photoreceptors and photoreceptor nuclei. The retinal pigmented epithelium demonstrated focal atrophy, loss of nuclei and pigment irregularity. Findings in the inner retina were notable for the loss of Müller cells and the presence of membranous cytoplasmic bodies. Retinae of control animals were entirely normal. In contrast to previous studies in the murine model examining chloroquine retinopathy subsequent to oral administration, this study suggests that intraperitoneal chloroquine administration facilitates retinal toxicity, presumably due to heightened drug absorption and bioavailability. It is posited that an increased rate of drug accumulation within the retina leads to an enhanced lysosomotrophic drug effect due to inability of the lysosome to compensate for chloroquine-induced elevation in pH through re-acidification of the intra-lysosomal content.

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Section: Discussionmentioning

confidence: 64%

Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection

Gaynes

Torczynski

Varro

et al. 2008

J of Applied Toxicology

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“…48 However, one limitation of this route is the first pass metabolism, as in the case of orally administered drugs, because substances absorbed from the peritoneal cavity end up in the portal vein and pass through the liver. 49,50,51 The toxicity effect is a major concern when applying herbal and dietary supplements. Little is known about the toxicity of cranberry extracts but in none of the reports employing various extracts was a toxic effect noted even in some studies where 4 fold (e.g.…”

Section: Food and Function Papermentioning

confidence: 99%

Studying the pharmacogenomic effect of cranberry extract on reducing body weight using collaborative cross mice

et al. 2021

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“…This leads to an increased absorption rate of the substance after IP administration 43 . However, one limitation of this route is the first pass metabolism, as in the orally administered drugs, because substances absorbed from the peritoneal cavity end up in the portal vein and pass through the liver 40,43,44 …”

Section: Discussionmentioning

confidence: 99%

Lowering fasting blood glucose with non‐dialyzable material of cranberry extract is dependent on host genetic background, sex and diet

Amer-Sarsour

Tarabeih

Ofek

et al. 2022

Anim Models and Exp Med

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Background: Type 2 diabetes (T2D) is a polygenic metabolic disease, characterized by high fasting blood glucose (FBG). The ability of cranberry (CRN) fruit to regulate glycemia in T2D patients is well known. Here, a cohort of 13 lines of the genetically diverse Collaborative Cross (CC) mouse model was assessed for the effect of non-dialyzable material (NDM) of cranberry extract in lowering fasting blood glucose.Methods: Eight-week-old mice were maintained on either a standard chow diet (control group) or a high-fat diet (HFD) for 12 weeks, followed by injections of intraperitoneal (IP) NDM (50 mg/kg) per mouse, three times a week for the next 6 weeks.Absolute FBG (mg/dl) was measured bi-weekly and percentage changes in FBG (%FBG) between weeks 0 and 12 were calculated.Results: Statistical analysis showed a significant decrease in FBG between weeks 0 and 12 in male and female mice maintained on CHD. However, a non-significant increase in FBG values was observed in male and female mice maintained on HFD during the same period. Following administration of NDM during the following 6 weeks, the results show a variation in significant levels of FBG lowering between lines, male and female mice and under the different diets. Conclusion:The results suggest that the efficacy of NDM treatment in lowering FGB depends on host genetic background (pharmacogenetics), sex of the mouse (pharmacosex), and diet (pharmacodiet). All these results support the need for follow-up research to better understand and implement a personalized medicine approach/utilization of NDM for reducing FBG. K E Y W O R D Schow diet (CHD), collaborative cross (CC) mouse model, fasting blood glucose (FBG), high-fat diet (HFD), non-dialyzable material (NDM) of cranberry extract, type 2 diabetes (T2D)

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A Pharmacokinetic Model for Intraperitoneal Administration of Drugs: Application to Teniposide in Humans

Cited by 10 publications

References 5 publications

Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection

Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection

Studying the pharmacogenomic effect of cranberry extract on reducing body weight using collaborative cross mice

Lowering fasting blood glucose with non‐dialyzable material of cranberry extract is dependent on host genetic background, sex and diet

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