A pharmacokinetic model optimized by covariates for propofol target-controlled infusion in dogs

Cattai, Andrea; Bizzotto, Roberto; Cagnardi, P.; Cesare, Federica Di; Franci, Paolo

doi:10.1016/j.vaa.2019.04.009

Cited by 7 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, all dogs were pre-medicated intramuscularly using a combination of 0.03 mg/kg acepromazine (Acepran 0.2%, Vetnil, SP, Brazil) and 0.2 mg/kg methadone (Mytedom 1%, Cristália, SP, Brazil). Then, anesthesia was induced 30 min later and maintained with propofol (Propotil 1%, BioChimico, RJ, Brazil) using STCI according to the dog PK parameters proposed by Cattai et al [6], using the plasma concentration of propofol (5 μg/mL) as a target. Next, PK data, the volume of distribution, and intercompartmental transfer constants used were obtained from the modeling proposed by Cattai et al [6], considering the following covariates: Weight, age, size, premedication, and sex.…”

Section: Methodsmentioning

confidence: 99%

“…Then, anesthesia was induced 30 min later and maintained with propofol (Propotil 1%, BioChimico, RJ, Brazil) using STCI according to the dog PK parameters proposed by Cattai et al [6], using the plasma concentration of propofol (5 μg/mL) as a target. Next, PK data, the volume of distribution, and intercompartmental transfer constants used were obtained from the modeling proposed by Cattai et al [6], considering the following covariates: Weight, age, size, premedication, and sex. PK values were also modeled for each animal and entered the TivaTrainer v.9.1 software (https://www.tivatrainer.com/) using the TCI function plasmatic concentration mode.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the anesthetic depth and bispectral index during propofol sequential target-controlled infusion in dogs

et al. 2022

View full text Add to dashboard Cite

Background and Aim: The use of anesthetic infusions based on pharmacokinetic values associated with anesthetic plan and bispectral index in dogs have not been well-documented in the literature. This study aimed to evaluate the bispectral index (BIS) change based on pre-propofol and establish clinical anesthetic depth changes during propofol sequential target-controlled infusion (STCI) in dogs with a plasma target of 5 μg/mL. Materials and Methods: Twenty healthy male dogs aged 1-3 years and weighing 9.8-44 kg were recruited. These dogs were pre-medicated intramuscularly with methadone (0.2 mg/kg) and acepromazine (0.03 mg/kg). After 30 min, propofol anesthetic induction and maintenance were initiated using STCI according to dog pharmacokinetic (PK) parameters. Subsequently, the target plasma concentration of propofol was set at 5 μg/mL for both anesthetic induction and the 120 min maintenance. Then, TivaTrainer v.9.1 software was used to calculate anesthetic infusion rates in a TCI plasmatic concentration mode using the PKs model optimized by covariates for propofol TCI in dogs. The BIS value was recorded every 5 min from the beginning of induction until the end of anesthesia. Finally, analysis of variance was performed on numerical data using the Friedman test, followed by the Bonferroni adjustment (p<0.05). Results: A statistical difference was observed between the baseline BIS value (T0), with a median value of 84.5 (81-97), and BIS after every 15 min (T15) of inducing anesthesia. Surgical anesthetic depth was also reached in 18 of 20 dogs after 10 min of infusion and in all dogs after 20 min, with a median BIS value of 72 (53-89) at the time of surgical anesthesia depth. Results also showed no BIS variation (p<0.05) between anesthetic moments after anesthetic induction with a substantial amplitude of BIS in the surgical anesthetic depth. Moreover, the maximum depth of anesthesia in all dogs by clinical evaluation was reached after 20 min of anesthesia and then remained stable throughout the anesthetic period. Conclusion: This study suggested that most dogs (90%) attained a surgical depth of anesthesia within 15 min of STCI onset, with a plasma target of 5 μg/mL and no change in anesthetic depth throughout the period anesthesia lasted. Furthermore, median BIS values remained high even after dogs reached the surgical depth of anesthesia, indicating that the comparison of BIS values of dogs and humans should not be considered for classifying anesthetic and hypnotic depths in dogs.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Evaluation of the anesthetic depth and bispectral index during propofol sequential target-controlled infusion in dogs

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On day 11 a total body computed tomography (CT) was performed under intravenous anaesthesia in order to evaluate size and position of the mass and determine whether other internal organs were affected. After premedication with 0.03 mg/kg acepromazine (Fatro, Italy) and 0.1 mg/kg methadone (Dechra, The Netherlands) intramuscularly, propofol 1% (Merial, Italy) was administered using a target controlled infusion system to induce and maintain anesthesia [20]. A large, ovoid shaped, heterogeneous, moderately contrast enhancing (pre-and post-contrast enhancement 32 ± 9 HU and 63 ± 9 HU, respectively) mass, measuring 12.72 cm in length, 6.52 cm in height and 8.33 cm in width, was visible on CT.…”

Section: Case Presentationmentioning

confidence: 99%

Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch

et al. 2020

View full text Add to dashboard Cite

Background: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch. Case presentation: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4.94 ng/ml). Because of the possibility of progesterone responsiveness causing further increase of the vaginal mass and since the bitch was a poor surgical candidate a 10 mg/kg aglepristone treatment was started SC on referral day 1. A computerized tomography showed a 12.7 × 6.5 × 8.3 cm mass causing urethral and rectal compression, ureteral dilation and hydronephrosis. A vaginal leiomyoma was diagnosed on histology. As serum progesterone concentration kept increasing despite aglepristone treatment, a 0.02 ng/mL twice daily IM alfaprostol treatment was started on day 18. As neither treatment showed remission of clinical signs or luteolysis, ovariohysterectomy was performed on referral day 35. Multiple corpora lutea were found on both ovaries. On histology a luteoma was diagnosed on the left ovary. P4 levels were undetectable 7 days after surgery. Recovery was uneventful and 12 weeks after surgery tomography showed a reduction of 86.7% of the vaginal mass. The bitch has been in good health and able to urinate without any complication ever since. Conclusions: This case demonstrates the importance of identifying progesterone related conditions as well as the importance of judiciously using a combined medical and surgical approach.

show abstract

General Pharmacology of Anesthetic and Analgesic Drugs

Whittem,

Beths,

Bauquier

2024

Veterinary Anesthesia and Analgesia

View full text Add to dashboard Cite

A pharmacokinetic model optimized by covariates for propofol target-controlled infusion in dogs

Cited by 7 publications

References 35 publications

Evaluation of the anesthetic depth and bispectral index during propofol sequential target-controlled infusion in dogs

Evaluation of the anesthetic depth and bispectral index during propofol sequential target-controlled infusion in dogs

Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch

General Pharmacology of Anesthetic and Analgesic Drugs

Contact Info

Product

Resources

About