A pharmacokinetic study of patchouli alcohol after a single oral administration of patchouli alcohol or patchouli oil in rats

Abstract

Pogostemonis herba is used in traditional Chinese medicine to remove dampness, relieve sunstroke, stop vomiting and increase appetite. Patchouli alcohol, an ingredient in pogostemonis herba, has the potential to treat inflammation as well as bacterial and fungal infections. The essential oil of pogostemonis herba (patchouli oil) is commonly given orally in clinical settings; however, no pharmacokinetic studies have examined its oral administration. The goal of this study was to investigate the pharmacokinetic behavior of patchouli alcohol following single-dose oral administration in rats; the influence of other patchouli oil components on the pharmacokinetic profile of patchouli alcohol was also examined. In this study, a simple and selective GC/MS method was developed and validated to measure the level of patchouli alcohol in rat plasma. The study revealed that the pharmacokinetics profile was linear in both the patchouli alcohol and patchouli oil groups. The C max and AUC0-t of patchouli alcohol were greater in all three doses of patchouli alcohol compared to corresponding patchouli oil doses. Additionally, the T max values were significantly greater in the patchouli oil group. These results suggest that the other ingredients in patchouli oil influence the pharmacokinetic behavior of patchouli alcohol during its absorption. The results provide a meaningful basis for evaluating the clinical application of patchouli oil and patchouli alcohol.

Patchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice

“…PA, PO, and β-PAE compose of 39%, 8.9%, and 3.0% of PAO, respectively (van Beek and Joulain, 2018). These components of PC exhibited common as well as unique pharmaceutical activities (Li et al, 2014; Zhang et al, 2016a; Zhang et al, 2016b). For example, reports showed that PEO, PA, PO, and β-PAE possessed anti-inflammation, anti-oxidant, anti-cancer, immunomodulation in cellular and animal studies (Li et al, 2011; Liao et al, 2013; Jeong et al, 2013; Dechayont et al, 2017).…”

Larvicidal and pupicidal evaluation of silver nanoparticles synthesized using Aquilaria sinensis and Pogostemon cablin essential oils against dengue and zika viruses vector Aedes albopictus mosquito and its histopathological analysis

“…The agarwood plays a role in traditional Chinese medicine (TCM) and a large amount of it is also being consumed by distillation to obtain an essential oil [15]. On the other hand, Pogostemonis Herba is the aerial part of dried Pogostemon cablin (Blanco) and it also plays a vital role in TCM for the treatment of various problems such as to remove dampness, relieve sunstroke, stop vomiting and increase appetite [16]. Patchouli oil is the essential oil of pogostemonis Herba, and it has been widely used by traditional Chinese physicians to treat a wide array of medical conditions such as common cold, nausea, diarrhoea, headache and fever since time memorial.…”

Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide-induced acute lung injury in mice

“…and 17.82±9.29 h (100 mg/kg, i.g.) detected in rats (58). PA is metabolized in the liver and kidney, and two hydroxylated metabolites have been demonstrated in the liver of rabbits (59), and one carboxylate metabolite of PA has been identified in rat urine (60).…”