A Phase 1 Trial of Highly Conformal, Hypofractionated Postprostatectomy Radiation Therapy

Patel, Krishnan R.; Rowe, Lindsay; Schott, Erica; Cooley-Zgela, Theresa; Ning, Holly; Türkbey, Barış; Choyke, Peter; Lindenberg, Liza; Mena, Esther; Pinto, Peter A.; Zhang, Qihu; Shih, Joanna H.; Salerno, Kilian E.; Citrin, Deborah E.

doi:10.1016/j.adro.2022.101024

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…SBRT as salvage therapy for radiorecurrent prostate cancer has been used for more than 15 years (9, 10, 12). Early case series were usually done with a Cyberknife treatment machine whereas newer studies included cohorts treated with C-arm Linacs or MR Linacs (10, 12-17, 19, 22-33, 40-42, 57-63). Of the 14 studies included in this meta-analysis, only three included patients that were exclusively treated on a Cyberknife (40-42).…”

Section: Discussionmentioning

confidence: 99%

“…Noticeably, earlier studies on SBRT for radiorecurrent prostate cancer were often done using a Cyberknife treatment machine (9,10,(12)(13)(14)(15)(16). In the last years, however, there has been increasing evidence on prostate re-irradiation using a C-arm LINAC or a MR LINAC (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

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Re-irradiation to the Prostate using stereotactic body radiotherapy (SBRT) after initial definitive Radiotherapy – A systematic review and Meta-analysis of recent trials

Schröder,

Tang,

Buchali

et al. 2024

Preprint

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Background: There is increasing data on re-irradiation to the prostate using stereotactic body radiotherapy (SBRT) after definite radiotherapy for prostate cancer. There has been increasing evidence on prostate re-irradiation using a C-arm LINAC or a MR LINAC in the last years. We therefore conducted this systematic review and meta-analysis on prostate re-irradiation including studies published from 2020-2023 to serve as an update on existing meta-analysis. Methods: We searched the Pubmed and Embase databases in October 2023 with queries including combinations of "repeat", "radiotherapy", "prostate", "re-irradiation", "reirradiation", "re treatment", "SBRT", "retreatment". Publication date was set to be from 2020 to 2023. There was no limitation regarding language. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. After data extraction, heterogeneity testing using I2. Afterwards a random effects model with a restricted maximum likelihood estimator was used for estimating the combined effect. Funnel plot asymmetry was assessed visually and using Eggers test to estimate the presence of publication and/or small study bias. Results: 14 publications were included in the systematic review. The rates of acute ≥ grade 2 (G2) GU and GI toxicities reported in the included studies range from 0.0-30.0% and 0.0-25.0% respectively. For late ≥G2 GU and GI toxicity, those values are 4.0-51.8% and 0.0-25.0%. The pooled rate of acute GU and GI toxicity ≥G2 were 13% (95% CI: 7-18%) and 2% (95% CI: 0-4%). For late GU and GI toxicity ≥G2 the pooled rates were 25% (95% CI: 14-35%) and 5% (95% CI: 1-9%). The pooled 2-year biochemical recurrence-free survival was 72% (95% CI: 64-92%). Conclusions: SBRT in the re-irradiation of radiorecurrent prostate cancer is overall safe and effective also when applied with a C-arm Linac or an MR Linac. Further prospective data are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Re-irradiation to the Prostate using stereotactic body radiotherapy (SBRT) after initial definitive Radiotherapy – A systematic review and Meta-analysis of recent trials

Schröder,

Tang,

Buchali

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…SBRT as salvage therapy for radiorecurrent prostate cancer has been used for more than 15 years [9] , [10] , [12] . Early case series were usually done with a Cyberknife treatment machine whereas newer studies included cohorts treated with C-arm Linacs or MR Linacs [10] , [19] , [42] , [43] , [12] , [13] , [14] , [15] , [16] , [17] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [58] , [59] , [60] , [61] , [62] , [63] , [64] . Of the 14 studies included in this meta -analysis, only three included patients that were exclusively treated on a Cyberknife [34] , [42] , [43] .…”

Section: Discussionmentioning

confidence: 99%

“…Noticeably, earlier studies on SBRT for radiorecurrent prostate cancer were often done using a Cyberknife treatment machine [9] , [10] , [12] , [13] , [14] , [15] , [16] . In the last years, however, there has been increasing evidence on prostate re-irradiation using a C-arm LINAC or a MR LINAC [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] as well as an increase in prospective data [24] , [30] , [33] , [34] , [26] , [27] , [28] .…”

Section: Introductionmentioning

confidence: 99%

Re-irradiation to the prostate using stereotactic body radiotherapy (SBRT) after initial definitive radiotherapy – A systematic review and meta-analysis of recent trials

Schröder,

Tang,

Lenffer

et al. 2024

Clinical and Translational Radiation Oncology

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Stereotactic body radiation therapy after radical prostatectomy: current status and future directions

Le Guevelou,

Magne,

Counago

et al. 2023

World J Urol

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A Phase 1 Trial of Highly Conformal, Hypofractionated Postprostatectomy Radiation Therapy

Cited by 3 publications

References 47 publications

Re-irradiation to the Prostate using stereotactic body radiotherapy (SBRT) after initial definitive Radiotherapy – A systematic review and Meta-analysis of recent trials

Re-irradiation to the Prostate using stereotactic body radiotherapy (SBRT) after initial definitive Radiotherapy – A systematic review and Meta-analysis of recent trials

Re-irradiation to the prostate using stereotactic body radiotherapy (SBRT) after initial definitive radiotherapy – A systematic review and meta-analysis of recent trials

Stereotactic body radiation therapy after radical prostatectomy: current status and future directions

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