A phenome-wide approach to identify causal risk factors for deep vein thrombosis

Abstract

ResultsForty-seven exposures passed an exposure-exposure correlation-adjusted Bonferroni P-value threshold (5.43E-05). These included previously hypothesised risk factors for DVT (e.g. body mass index, varicose veins, height, hyperthyroidism) and novel associations (e.g. prospective memory, basal metabolic rate). ConclusionOur analyses confirmed causal associations of risk factors previously associated with DVT and highlighted several novel risk factors for the disease. Our study demonstrates the utility of using a hypothesis free Mendelian randomization approach for the identification of novel disease risk factors.