2024
DOI: 10.1101/2024.05.16.594477
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A phosphate-binding pocket in cyclin B3 is essential for XErp1/ Emi2 degradation in meiosis I

Rebecca Demmig,
Michael Schäfer,
Elijah Johannes
et al.

Abstract: To ensure the correct euploid state of embryos, it is essential that vertebrate oocytes await fertilization arrested at metaphase of meiosis II. This MII arrest is mediated by XErp1/Emi2, which inhibits the ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome). Cyclin B3 in complex with Cdk1 (cyclin-dependent kinase 1) is essential to prevent an untimely arrest of vertebrate oocytes in meiosis I by targeting XErp1/Emi2 for degradation. Yet, the molecular mechanism of XErp1/Emi2 degradation in MI is not… Show more

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