A phosphoinositide-based model of actin waves in frustrated phagocytosis

León, Marco A. Avila Ponce de; Félix, Bryan; Othmer, Hans G.

doi:10.1016/j.jtbi.2021.110764

Cited by 3 publications

(2 citation statements)

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“… Schematic diagram of a partial set of key players signaling to F-actin assembly; colored lines represent interconversion (black), positive feedback (green), negative feedback (red), and dark (light) shades of similar background/text colors denote active (inactive) forms. For more detailed biochemical pathways, see, for example, Devreotes et al, 2017 ; Avila Ponce de León et al, 2021 . …”

Section: Experimental Observations Of Actin Wavesmentioning

confidence: 99%

“…The broad range of actin wave patterns has stimulated a wide spectrum of modeling approaches, varying greatly in their complexity and level of detail ( Ryan et al, 2012b ; Allard and Mogilner, 2013 ; Sept and Carlsson, 2014 ; Beta and Kruse, 2017 ; Beta et al, 2020 ). Some works start with detailed signaling circuits of interacting components ( Khamviwath et al, 2013 ; Avila Ponce de León et al, 2021 ), resulting in models that consist of large sets of coupled equations. In most situations, the exact functional forms and parameter values cannot be uniquely determined from experimental observations and are somewhat arbitrary.…”

Section: Mathematical Modeling Approachesmentioning

confidence: 99%

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From actin waves to mechanism and back: How theory aids biological understanding

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et al. 2023

eLife

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Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors with multiple feedback loops, often leading to emergent dynamic patterns in the form of propagating waves of actin polymerization activity that are poorly understood. Many in the actin wave community have attempted to discern the underlying mechanisms using experiments and/or mathematical models and theory. Here, we survey methods and hypotheses for actin waves based on signaling networks, mechano-chemical effects, and transport characteristics, with examples drawn from Dictyostelium discoideum, human neutrophils, Caenorhabditis elegans, and Xenopus laevis oocytes. While experimentalists focus on the details of molecular components, theorists pose a central question of universality: Are there generic, model-independent, underlying principles, or just boundless cell-specific details? We argue that mathematical methods are equally important for understanding the emergence, evolution, and persistence of actin waves and conclude with a few challenges for future studies.

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Section: Experimental Observations Of Actin Wavesmentioning

confidence: 99%