A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation

Abbaszadeh, Samin; Eskandari, Mohammad Reza; Nosrati-Siahmazgi, Vahideh; Musaie, Kiyan; Mehrabi, Soraya; Tang, Ruikang; Jafari, Mohammad Reza; Xiao, Bo; Sarmadi, Vahid Hosseinpour; Haghi, Fakhri; Chen, Bo Zhi; Guo, Xin Dong; Santos, Hélder A.; Shahbazi, Mohammad‐Ali

doi:10.1016/j.mtbio.2023.100609

Cited by 11 publications

(5 citation statements)

References 72 publications

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“…In addition, while the control PBS-treated group did not demonstrate an anticancer effect when exposed to NIR power densities of 0.8 and 1.2 W·cm 2– , a combination of NIR light and the aerogel could meaningfully reduce the viability of cancer cells to near 30% and less than 10%, respectively. These results are in line with previous studies that have reported that NIR-mediated PTT can induce cancer cell necroptosis and apoptosis …”

Section: Resultsmentioning

confidence: 99%

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Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

Abie,

Ünlü,

Pinho

et al. 2024

ACS Appl. Mater. Interfaces

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Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged bone tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO 2 -25CaO-5P 2 O 5 (BGNF). By synergistically combining the unique characteristics of these three components through self-assembly and microextrusion-based threedimensional (3D) printing, our goal was to produce durable and versatile aerogel-based 3D composite scaffolds. These scaffolds were designed to exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, and bone regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving the coordination of dihydroxyphenylalanine (DOPA) amino acids with ferric ions (Fe 3+ ), we synthesized a tris-complex catecholate-iron self-assembled composite gel. This gel formation occurred through the coordination of oxidized SF (SFO) with TA and polydopamine-modified BGNF (BGNF-PDA). The dynamic nature of the coordination ligand−metal bonds within the selfassembled SFO matrix provided excellent shear-thinning properties, allowing the SFO-TA-BGNF complex gel to be extruded through a nozzle, facilitating 3D printing into scaffolds with outstanding shape fidelity. Moreover, the developed composite aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial and in vitro photothermal antiosteosarcoma properties. In vitro studies showcased their excellent biocompatibility and osteogenic features as seeded cells successfully differentiated into osteoblasts, promoting bone regeneration in 21 days. Through comprehensive characterizations and biological validations, our antibacterial scaffold demonstrated promise as an exceptional platform for concurrent bone regeneration and bone cancer therapy, setting the stage for their potential clinical application.

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Section: Resultsmentioning

confidence: 99%

“…These results are in line with previous studies that have reported that NIRmediated PTT can induce cancer cell necroptosis and apoptosis. 57 3.3. In Vitro Osteogenic Potential of the SFO-TA-BGNF Aerogels.…”

Section: Nir Laser Triggered Photothermal Conversion Antibacterial Andmentioning

confidence: 99%

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

Abie,

Ünlü,

Pinho

et al. 2024

ACS Appl. Mater. Interfaces

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“…Photothermal therapy (PTT), which involves the use of suitable photothermal agents to convert laser energy into heat, has been well developed due to its noninvasive, remotely controllable, tissue-penetrating specificities, and minimal side-effects. − For example, heavy-atom-structured hypoxia-responsive probes for precise photoacoustic imaging and cancer therapy have been developed . In addition, heptacyanine nanodiagnostics with catalase-like activity can be used for synergistic phototherapy of cancer .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy

Wu,

Xiang,

Zhang

et al. 2024

Langmuir

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Wounds caused by bacterial infections have become a major challenge in the medical field; however, the overuse of antibiotics has led to increased resistance and bioaccumulation. Therefore, it is urgent to develop an antibacterial agent with excellent antibacterial properties and biosafety. Here, we designed an antibacterial platform that combines photothermal and chemical kinetics therapies. Platinum−cobalt (PtCo) bimetallic nanoparticles (NPs) were first prepared, and then PtCo@MnO 2 nanoflowers were obtained by adding MES buffer solution and KMnO 4 to the PtCo bimetallic nanoparticle suspension using ultrasound. When light strikes metal NPs, they can strongly absorb the photon energy, resulting in photothermal properties. In addition, Pt and Co were used as the oxidase mimics, and MnO 2 was used as the catalase mimic. In summary, the photothermal capacity of PtCo@MnO 2 nanoflowers with rough surfaces can effectively disrupt the permeability of the bacterial cell membranes. Further, by catalyzing H 2 O 2 , PtCo@MnO 2 nanoflowers can generate large amounts of hydroxyl free radicals, which can damage bacterial cell membranes, proteins, and DNA. In addition, MnO 2 can effectively alleviate the hypoxic environment of the bacterially infected areas and activate deep bacteria, thus achieving the goal of complete sterilization. The in vitro and in vivo results showed that PtCo@MnO 2 displayed excellent antibacterial properties and good biocompatibility.

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“…Oral administration is non-invasive, convenient, and safe, but it has the disadvantage of easy degradation of drugs through the gastrointestinal tract. 1 Intravenous injection has the advantages of rapid onset and easy control of blood drug concentration; however, it also has some disadvantages, such as poor drug targeting, 2,3 leakage before reaching the target, 4 easy clearance, 5 and inability to pass through the blood–brain barrier. 6 Local administration includes local injection and transdermal administration.…”

Section: Introductionmentioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation

Cited by 11 publications

References 72 publications

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties

Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy

Applications and prospects of microneedles in tumor drug delivery

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