A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation

Mi, Yongsheng; Cheng, Hong; Chu, Hongqian; Zhao, Jian; Yu, Mingming; Gu, Zhanjun; Zhao, Yuliang; Li, Lele

doi:10.1039/c9sc03524a

Cited by 54 publications

(34 citation statements)

References 62 publications

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“…Despite high φ 1O2 values for many of the examples cited, the effectiveness of these systems depends strongly on the nature of the coordinated metal, as it promotes intersystem crossing (ISC) through the heavy atom effect . Other effective 1 O 2 photosensitizers are based on nanoparticles, nanosheets, or metal–organic frameworks . However, these compounds often require elaborate syntheses with numerous purification steps, and frequently suffer from low solubility and poor long‐term stability.…”

Section: Introductionmentioning

confidence: 99%

Wavelength‐Dependent Singlet Oxygen Generation in Luminescent Lanthanide Complexes with a Pyridine‐Bis(Carboxamide)‐Terthiophene Sensitizer

Johnson

Vittardi

Gracia-Nava

et al. 2020

Chemistry A European J

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Lanthanide ion (LnIII) complexes, [Ln(3Tcbx)2]3+ (LnIII=YbIII, NdIII, ErIII) are isolated with a new pyridine‐bis(carboxamide)‐based ligand with a 2,2′:5′,2′′‐terthiophene pendant (3TCbx), and their resulting photophysical properties are explored. Upon excitation of the complexes at 490 nm, only LnIII emission is observed with efficiencies of 0.29 % at 976 nm for LnIII=YbIII and 0.16 % at 1053 nm for LnIII=NdIII. ErIII emission is observed but weak. Upon excitation at 400 nm, concurrent 1O2 formation is seen, with efficiencies of 11 % for the YbIII and NdIII complexes and 13 % for the ErIII complex. Owing to the concurrent generation of 1O2, as expected, the efficiency of metal‐centered emission decreases to 0.02 % for YbIII and 0.05 % for NdIII. The ability to control 1O2 generation through the excitation wavelength indicates that the incorporation of 2,2′:5′,2′′‐terthiophene results in access to multiple sensitization pathways. These energy pathways are unraveled through transient absorption spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Wavelength‐Dependent Singlet Oxygen Generation in Luminescent Lanthanide Complexes with a Pyridine‐Bis(Carboxamide)‐Terthiophene Sensitizer

Johnson

Vittardi

Gracia-Nava

et al. 2020

Chemistry A European J

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“…NIR irradiation resulted in the photoisomerization of diarylethene from close to open conformation, enabling complete recovery of 1 O 2 generation ability for switchable photodynamic cancer therapy. [245] Although reversible photoisomerization provides an opportunity to develop cyclic on and off multipulse delivery platforms for drug delivery in vivo, there are some limitations that may hinder its use in practice. One concern of the photoisomerizable molecules is its potential toxicity in vivo.…”

Section: Nir Light-triggered Photoisomerization Drug Delivery Systemsmentioning

confidence: 99%

Section: Photoisomerization‐based Drug Releasementioning

confidence: 99%

Light: A Magical Tool for Controlled Drug Delivery

Tao

Chan

Shi

et al. 2020

Adv Funct Materials

188

141

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Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application, and exquisite temporal and spatial control. Great progress is achieved in the development of novel light-driven drug delivery strategies with both breadth and depth. Light-controlled drug delivery platforms can be generally categorized into three groups: photochemical, photothermal, and photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, metal sulfides and oxides, metal-organic frameworks, carbon nanomaterials, upconversion nanoparticles, semiconductor nanoparticles, stimuli-responsive micelles, polymer-and liposome-based nanoparticles are applied for light-stimulated drug delivery. In view of the increasing interest in on-demand targeted drug delivery, the development of light-responsive systems with a focus on recent advances, key limitations, and future directions is reviewed.

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“…PDT is a non-invasive therapy based on the generation of 1 O 2 and reactive oxygen species (ROS). The latter, generated through the interaction of the triplet level of a dye with ground state oxygen ( 3 O 2 ) (Figure 18), is used to damage cancerous cells [79,87,[266][267][268][269][270][271][272][273][274]. Cells and organisms are less likely to develop resistance to 1 O 2 , and it can therefore, be used successfully to treat cancer [79].…”

Section: Photodynamic Therapy Using Persistent Luminescencementioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

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A photochromic upconversion nanoarchitecture: towards activatable bioimaging and dual NIR light-programmed singlet oxygen generation

Abstract: A novel upconversion nanoarchitecture is designed, whose 980 nm light photosensitized activity could be activated by 808 nm light.

Cited by 54 publications

References 62 publications

Wavelength‐Dependent Singlet Oxygen Generation in Luminescent Lanthanide Complexes with a Pyridine‐Bis(Carboxamide)‐Terthiophene Sensitizer

Wavelength‐Dependent Singlet Oxygen Generation in Luminescent Lanthanide Complexes with a Pyridine‐Bis(Carboxamide)‐Terthiophene Sensitizer

Light: A Magical Tool for Controlled Drug Delivery

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

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