A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing

Li, Chunyang; He, Xiaojun; Li, Qingfeng; Lv, Mingzhi; Shen, Jianliang; Jin, Lin; He, Dawei

doi:10.1038/s41427-022-00456-7

Cited by 29 publications

(26 citation statements)

References 50 publications

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“…developed a polydopamine‐hyaluronic acid‐based hydrogel loading lauric acid/indocyanine green‐coated CaO 2 and MnO 2 composite nanoparticles (CaO 2 ‐ICG@LA@MnO 2 ). [ 42 ] The CaO 2 ‐ICG@LA@MnO 2 nanoparticles prevented the direct exposure of CaO 2 to H 2 O. The O 2 generation of CaO 2 ‐ICG@LA was slightly lower than that of pure CaO 2 nanoparticles, while CaO 2 ‐ICG@LA@MnO 2 exhibited faster release of O 2 due to CAT‐like activity of MnO 2 .…”

Section: Oxygen‐generating Hydrogels Via Decomposition Of Metal Perox...mentioning

confidence: 99%

Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing

Yang,

Ren,

Chen

et al. 2023

Adv Healthcare Materials

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Hypoxia in chronic wounds impairs the activities of reparative cells, resulting in tissue necrosis, bacterial infections, decreased angiogenesis, and delayed wound healing. To achieve effective oxygenation therapy and restore oxygen homeostasis, oxygen‐generating hydrogels based on different oxygen sources have been developed to release dissolved oxygen in the wound bed, which not only alleviate hypoxia, but also accelerate chronic wound healing. This review first discusses the vital role of oxygen and hypoxia in the wound healing process. The advancements in oxygen‐generating hydrogels, which produce oxygen through the decomposition of hydrogen peroxide, metal peroxides, glucose‐activated cascade reactions, and photosynthesis of algae microorganisms for chronic wound healing, are discussed and summarized. The therapeutic effects and challenges of using oxygen‐generating hydrogels for the clinical treatment of chronic wounds are concluded and prospected.

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Section: Oxygen‐generating Hydrogels Via Decomposition Of Metal Perox...mentioning

confidence: 99%

Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing

Yang,

Ren,

Chen

et al. 2023

Adv Healthcare Materials

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“…Besides the ones mentioned above, one of the most recent and effective biomaterials used for oxygen deficiency is peroxide-based hydrogels due to their ability to generate oxygen via chemical reaction. [72][73][74][75][76][77][78][79][80] CaO 2 , Na 2 CO 3 , and H 2 O 2 are the ones most commonly used. H 2 O 2 is one of the reliable molecules used in wound healing applications with oxygen generation, as it releases only oxygen and water into the medium when dissolved.…”

Section: Peroxide-based Oxygen Delivery Biomaterialsmentioning

confidence: 99%

“…In this system, NIR photosensitized Indocyanine green released singlet oxygen ( 1 O 2 ) (type of ROS) and Reproduced under terms of the CC-BY license. [74] Copyright 2023, The Authors, published by Springer Nature.…”

Section: Peroxide-based Oxygen Delivery Biomaterialsmentioning

confidence: 99%

Oxygen Delivery Biomaterials in Wound Healing Applications

Bayraktar,

Üstün,

Kehr

2023

Macromolecular Bioscience

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Oxygen (O2) delivery biomaterials have attracted great interest in the treatment of chronic wounds due to their potential applications in local and continuous O2 generation and delivery, improving cell viability until vascularization occurs, promoting structural growth of new blood vessels, simulating collagen synthesis, killing bacteria and reducing hypoxia‐induced tissue damage. Therefore, different types of O2 delivery biomaterials including thin polymer films, fibers, hydrogels, or nanocomposite hydrogels have been developed to provide controlled, sufficient and long‐lasting O2 to prevent hypoxia and maintain cell viability until the engineered tissue is vascularized by the host system. These biomaterials are made by various approaches, such as encapsulating O2 releasing molecules into hydrogels, polymer microspheres and 3D printed hydrogel scaffolds and adsorbing O2 carrying reagents into polymer films of fibers. In this article, different O2 generating sources such as solid inorganic peroxides, liquid peroxides, and photosynthetic microalgae, and O2 carrying perfluorocarbons and hemoglobin are presented and the applications of O2 delivery biomaterials in promoting wound healing are discussed. Furthermore, challenges encountered and future perspectives are highlighted.

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“…[3][4][5] Moreover, regulating the heat dose to mild levels has been shown to significantly enhance wound healing. [6,7] Furthermore, neuromodulation via photothermal heating was recently proposed as a therapeutic strategy to prevent ventricular arrythmias and to treat depression. [8,9] While these examples highlight the versatility of the technology, a comprehensive understanding of cell response to heat is lacking.…”

Section: Introductionmentioning

confidence: 99%

A Laser‐Driven Microrobot for Thermal Stimulation of Single Cells

Harder,

İyisan,

Wang

et al. 2023

Adv Healthcare Materials

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Here, the study presents a thermally activated cell‐signal imaging (TACSI) microrobot, capable of photothermal actuation, sensing, and light‐driven locomotion. The plasmonic soft microrobot is specifically designed for thermal stimulation of mammalian cells to investigate cell behavior under heat active conditions. Due to the integrated thermosensitive fluorescence probe, Rhodamine B, the system allows dynamic measurement of induced temperature changes. TACSI microrobots show excellent biocompatibility over 72 h in vitro, and they are capable of thermally activating single cells to cell clusters. Locomotion in a 3D workspace is achieved by relying on thermophoretic convection, and the microrobot speed is controlled within a range of 5–65 µm s−1. In addition, light‐driven actuation enables spatiotemporal control of the microrobot temperature up to a maximum of 60 °C. Using TACSI microrobots, this study targets single cells within a large population, and demonstrates thermal cell stimulation using calcium signaling as a biological output. Initial studies with human embryonic kidney 293 cells indicate a dose dependent change in intracellular calcium content within the photothermally controlled temperature range of 37–57 °C.

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A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing

Cited by 29 publications

References 50 publications

Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing

Oxygen‐Generating Hydrogels as Oxygenation Therapy for Accelerated Chronic Wound Healing

Oxygen Delivery Biomaterials in Wound Healing Applications

A Laser‐Driven Microrobot for Thermal Stimulation of Single Cells

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