A Photothermal-Response Oxygen Release Platform Based on Hydrogel for Accelerating Wound Healing

Abstract

During wound healing, oxygen availability and anti-inflammatory microenvironment play an important role inthe formation of new tissue. However, whether to provide continuous and controllable oxygen around the injured tissue while inhibiting inflammation, and realize the synergistic effect of oxygen supply and anti-inflammation, is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and theinflammatory microenvironment, a photothermal response-assisted strategy has been developed in this work. We prepared composite hydrogel system of PDA-HA (polydopamine-hyaluronic acid)hydrogel-loaded CaO2-ICG@LA@MnO2(calcium peroxide-indocyanine green@lauric acid@manganese dioxide)nanoparticles, which showed excellent photothermal performanceunder near-infrared (NIR) irradiation, and realized the on-off release of oxygen and reactive oxygen species (ROS). Controlled and sustained oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believethat the system we have obtained can be used as a new approach for treating chronic wound healing.