A physicochemical study of a modified sol–gel derived neodymium-hydroxyapatite

Herradi, Smaiel; Adouar, Imane; Bouhazma, Sara; Chajri, Sanae; Khaldi, Mohammed; Bali, Brahim El; Lachkar, Mohammed

doi:10.1016/j.matpr.2022.01.375

Cited by 3 publications

(3 citation statements)

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“…The synthesis of HA using sol-gel demands that the Ca/P ratio is 1.67. However, depending on the experimental conditions (pH, temperature, aging time), different quantities of β-TCP can be formed [71]. Nellis et al also confirmed that this route offers the capacity to obtain more versatile materials with good biocompatibility [72].…”

Section: Synthesis Methodsmentioning

confidence: 97%

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.

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Section: Synthesis Methodsmentioning

confidence: 97%

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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“…Nd 3+ has an ionic radius of 1.109 Å [ 69 ]. According to the XRD profiles of 1Nd-HAp, 5Nd-HAp, 10Nd-HAp and 20Nd-HAp elaborated by an ion-exchange method, only the latest presented a HAp phase and a Nd(OH) 3 phase (18%).…”

Section: Impact Of Lanthanide Incorporation On the Morphology And Pro...mentioning

confidence: 99%

“…With different Nd 3+ concentrations added by the precipitation method, a reduction in NP size was reported [ 71 , 72 ]. The crystallinity of the NPs can be reduced after 4 h of calcination at 700 °C of NPs synthesized by the sol-gel method and with increasing Nd 3+ concentrations [ 69 ].…”

Section: Impact Of Lanthanide Incorporation On the Morphology And Pro...mentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

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