A Physiochemical Study on Drug Delivery of Metformin HCL-Loaded Cs-Plga Nanoparticles

Abstract

Objective: The current research was based on developing CS-PLGA nanoparticles (NPs) drug delivery system (DDS) for improving the bio-availability of metformin HCl, an anti-diabetic drug. Methods: Nanoprecipitation method was utilized to prepare the metformin HCl-loaded CS-PLGA NPs DDS. The metformin HCl-loaded NPs were validated using an analytical method and characterization of NPs was also done. These polymers release the drug in a controlled manner. Results: The correlation coefficient (R2) value for the metformin HCl calibration curve was 0.9971 in phosphate buffer pH 6.8 at a concentration range of 0-12 μg/ml. Metformin HCl-loaded NPs release the drug at 144 h, approximately 90%. DSC tests were carried out for 50 mg and 75 mg of MET HCl incorporated NPs and FT-IR for 50 mg of MET HCl incorporated NPs, it was clear from the FT-IR and DSC spectra that there were no interactions between the metformin HCl and the polymer. Conclusion: It was proven that metformin HCl-loaded NPs act as a prominent DDS by exhibiting extensive drug release and an increase in its bioavailability.

Comparative Study on Biological Activities and Chemical Profiling of Mushroom (Pleurotus pulmonarius (Fr.) Quel.) Cultured on Lignocellulosic Agro Wastes

“…Edible mushrooms have become popular nowadays due to their excellent taste, richness in nutritional content, ease of purchase, medicinal value, and attraction as functional foods. The significant importance of mushrooms is attributed to their medical properties, organoleptic value, and economic importance [1,4,5] . Scientific research shows that mushroom contains metabolites with several biological activities such as antidiabetic, antioxidant, antitumor, and anti‐inflammatory effect [6,7] .…”

“…The significant importance of mushrooms is attributed to their medical properties, organoleptic value, and economic importance. [1,4,5] Scientific research shows that mushroom contains metabolites with several biological activities such as antidiabetic, antioxidant, antitumor, and anti-inflammatory effect. [6,7] It is also helpful in preventing hypertension, hypercholesterolemia, and cancer.…”