A Phyto-Pharmacological Overview on Oroxylum Indicum (Linn.) Vent.

Bhardwaj, Abhay

doi:10.21474/ijar01/7521

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…O. indicum is commonly known as Sonaphata, Sona, Shyonaaka, and Indian trumpet tree. It grows in India and is used as traditional Ayurveda medicine (Bhardwaj, 2018). Scutellarein 7-rutinoside is a derivative of scutellarein, which is found in Scutellaria baicalensis.…”

Section: Herbal Source Of the Selected Ligandsmentioning

confidence: 99%

Virtual Screening of Natural Compounds Against Six Protein Receptors Coded by The SARS-CoV-2 Genome

Awaluddin¹,

Batubara

Wahyudi

2023

molekul

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes Coronavirus 2019 (COVID-19). To date, there has been no proven effective drug for the treatment or prevention of COVID-19. A study on developing inhibitors for this virus is carried out using molecular docking simulation methods. 3CL-Pro, PL-Pro, Helicase, N, E, and M protein were used as protein targets. Autodock Vina, Autodock 4.2, and PSOVina were used in this study. This study aims to obtain a model of ligands interactions of active natural compounds against the receptor protein encoded by the SARS-CoV-2 genome and their free binding energy to propose active compounds from natural products that have potential as a drug for COVID-19. Corilagin (-14,42 kcal/mol), Scutellarein 7-rutinoside (-13,2 kcal/mol), Genistein 7-O-glucuronide (-10,52 kcal/mol), Biflavonoid-flavone base + 3O (-11,88 and -9,61 kcal/mol), and Enoxolone (-6,96 kcal/mol) has the best free energy value at each protein target indicating that the compound has the potential as a viral protein inhibitor for further investigation. This research is limited to computer simulations, where the results obtained are still a prediction.

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Section: Herbal Source Of the Selected Ligandsmentioning

confidence: 99%