A phytochemical study of the Cuphea glutinosa from Southern Brazil: Na+,K+-ATPase activity inhibition and antioxidant properties

Zago, Adriana Maria; Carvalho, Fabiano B.; Gutierres, Jessié Martins; Bohnert, Crystiani; Fernandes, Marilda da Cruz; Morandini, Liziane Maria Barassuol; Coelho, Helena S.; Fogaça, Aline de Oliveira; Andrade, Cínthia Melazzo de; Mostardeiro, Marco A.; Dalcol, Ionara I.; Morel, Ademir F.

doi:10.1080/14786419.2018.1477143

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Traditionally, Cuphea has been widely used for the treatment of cardiovascular disorders, including arterial hypertension and heart diseases. , The ethanolic extract of the aerial parts of Cuphea carthagenensis (Jacq.) J.F.Macbr.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

et al. 2022

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Cuphea ignea A. DC. is an ornamental tropical plant belonging to the family Lythraceae. The aim of this study is to verify the in vivo antihypertensive potential of C. ignea A. DC. and to explore its metabolic profile using a UHPLC-Orbitrap-HRMS technique. The results revealed that the ethanolic extract of the leaves in two doses (250 and 500 mg/kg b.wt.) significantly normalized the elevated systolic blood pressure in N(G)-nitro-l-arginine-methyl ester-induced hypertension in rats. An angiotensin-converting enzyme (ACE) concentration was significantly decreased by the high dose extract compared to lisinopril. Nitric oxide (NO) level was significantly restored by both doses. Concerning the oxidative stress parameters, both doses displayed significant reduction in malondialdehyde (MDA) level while the high dose restored elevated glutathione level. These biochemical results were clearly supported by the histopathological examination of the isolated heart and aorta. A UHPLC-Orbitrap-HRMS study was represented by a detailed metabolic profile of leaves and flowers of C. ignea A. DC., where 53 compounds were identified among which flavonoids, fatty acids, and hydrolysable tannins were the major identified classes. This study established scientific evidence for the use of C. ignea A. DC., a member of genus Cuphea as a complementary treatment in the management of hypertension.

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Section: Introductionmentioning

confidence: 99%

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

et al. 2022

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“…carthagenensis , they were less effective—at a concentration of 100 ng/mL, they inhibited the enzyme by 22.82% (Unistalda) and 22.29% (Barros Cassal). C. glutinosa is another species known for its hypotensive activity [ 63 ]. The plant is used in traditional Brazilian medicine to treat various cardiovascular problems: abnormal heart rhythms, heart failure, hypertension, and atherosclerosis.…”

Section: Pharmacological Activity Of Cuphea Plants...mentioning

confidence: 99%

“…As mentioned above, Cuphea s are rich in polyphenols that are well-known natural antioxidants [ 27 ]. For this reason, many studies have focused on the in vitro antioxidant activity of Cuphea plants [ 16 , 17 , 48 , 52 , 63 , 92 , 103 ]. The results of these studies are presented in Table 4 .…”

Section: Pharmacological Activity Of Cuphea Plants...mentioning

confidence: 99%

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The Genus Cuphea P. Browne as a Source of Biologically Active Phytochemicals for Pharmaceutical Application and Beyond—A Review

Sobolewska

Michalska

Wróbel‐Biedrawa

et al. 2023

IJMS

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Cuphea P. Browne (Lythraceae) is a monophyletic taxon comprising some 240–260 species that grow wild in the warm, temperate, and tropical regions of South and Central America and the southern part of North America. They have been valued as traditional medicinal remedies for numerous indications, including treating wounds, parasitic infections, hypertension, digestive disorders, cough, rheumatism, and pain. Modern pharmacological research provides data that support many of these traditional uses. Such a wide array of medicinal applications may be due to the exceptionally rich phytochemical profile of these plants, which includes bioactive compounds classified into various metabolite groups, such as polyphenols, triterpenes, alkaloids, and coumarins. Furthermore, Cuphea seed oils, containing medium-chain fatty acids, are of increasing interest in various industries as potential substitutes for coconut and palm oils. This review aims to summarize the results of phytochemical and pharmacological studies on Cuphea plants, with a particular focus on the therapeutic potential and molecular mechanisms of the action of polyphenolic compounds (especially flavonoids and tannins), which have been the subject of many recently published articles.

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“…3, 163.9, 132.3, 121.7, 113.7, 55.5; EI-MS m/z (%): 152 [M] + (65), 151 (100), 135(52), 123 (18), 84 (10), 77 (15), 49 (11) [16]. (100), 153(89), 125 (20), 79 (18), 45(42) [23].…”

Section: Extraction and Isolationmentioning

confidence: 99%

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa

et al. 2022

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In the continuous search for α-glucosidase inhibitors, eleven phenolic compounds (1-11) were isolated from the root bark of Paeonia suffruticosa. Their α-glucosidase inhibitory activity and inhibition mechanism were investigated using an in vitro inhibition assay and molecular docking studies. Compounds 2, 5, 6, and 8-11 (IC 50 between 290 and 431 µM) inhibited α-glucosidase more effectively than the reference compound acarbose (IC 50 =1463 ± 29.5 µM). Among them, compound 10 exhibited the highest α-glucosidase inhibitory effect with an IC 50 value of 290.4 ± 9.6 µM. Compounds 2, 5, 9 10 and 11 were found to be competitive inhibitors, while compounds 6 and 8 were noncompetitive inhibitors of α-glucosidase. Computational analyses showed that the main binding forces between the compounds and the main residues were hydrogen bonds. The results indicated that these compounds had considerable α-glucosidase inhibitory activity.

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A phytochemical study of the Cuphea glutinosa from Southern Brazil: Na⁺,K⁺-ATPase activity inhibition and antioxidant properties

Cited by 7 publications

References 15 publications

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

The Genus Cuphea P. Browne as a Source of Biologically Active Phytochemicals for Pharmaceutical Application and Beyond—A Review

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa

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