A phytomodulatory hydrogel with enhanced healing effects

Vasconcelos, Mirele S.; Souza, Tamiris de Fátima Goebel de; Figueiredo, Ingrid Samantha Tavares de; Sousa, Emília Tomé de; Sousa, Felipe Domingos de; Moreira, Renato A.; Alencar, Nylane Maria Nunes de; Lima‐Filho, José Vitor; Ramos, Márcio V.

doi:10.1002/ptr.6018

Cited by 17 publications

(6 citation statements)

References 27 publications

(36 reference statements)

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“…In the reparative phase the division of keratinocytes, which facilitate re-epithelialisation, is promoted [10]. In addition, the wound is optimally supplied with oxygen by the respiratory activity and wound contraction is promoted [ [27] see Figure 3].…”

Section: Discussionmentioning

confidence: 99%

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Rüther¹,

Voss²

2021

Heliyon

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Purpose Five different galenics were analyzed and compared concerning tissue breathability and gas exchange with the environment after an application period of 6 h on pig ear skin. Aim was to find the most suitable galenics for efficient moist treatment for everyday injuries (abrasions, lacerations and cuts) without influencing the transepidermal water loss. Methods A quantity of 0.1 g of the different test preparations was applied once topically to an area of 2 cm 2 . The analysis of the breathability was performed by TEWL (transepidermal water loss) measurements in the first hour after product application. The moisture retention effect was assessed by corneometry in the first 5 h after product application. Results The hydrogel preparations showed a higher breathability in contrast to a semi-occlusive ointment and petrolatum. The same applies to the moisture penetration of the skin. Here, all hydrogel formulations showed the highest tissue hydration. After 3 h an additional increase in moisture was observed for the areas treated with Tyrosur® CareExpert Wound Gel and the ointment. Conclusion In contrast to petrolatum and the semi-occlusive ointment, treatment with the hydrogels led to a preservation of the breathability and good moistening of the tissue, which is due to the galenics of the gels consisting of water, carbomer and propylene glycol. The increase in moisture after 3 h in areas treated with Tyrosur® CareExpert Wound Gel and the semi-occlusive ointment indicates a sustained moisturizing effect mediated by dexpanthenol.

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Section: Discussionmentioning

confidence: 99%

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Rüther¹,

Voss²

2021

Heliyon

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“…The topic treatment with CrMFSOL stimulated the early formation of a new epithelium and a remodeling of connective tissue, with a higher collagen deposition after 7 days. Similarly, a phytomodulatory hydrogel with hemicelluloses extracted from seeds of Caesalpinia pulcherrima (Fabaceae) and mixed with phytomodulatory proteins obtained from the latex of Calotropis procera, enhanced the healing effects by high collagen deposition and modulating some aspects of the inflammatory phase (Vasconcelos et al, 2018). Corroborating with this data, it was discovered that the methanol fraction of quixaba leaves (MFSOL), contains as a main component, the NMP, a derivative from L-proline (amino acid precursor of collagen), that showed cicatrizant effect in the topical treatment of induced excisional lesions in mice, through modulation of the inflammatory response, and increase of the antioxidant response and stimulation of the production of collagen fibers (Aquino et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Human keratinocyte (HaCaT) stimulation and healing effect of the methanol fraction from the decoction from leaf fromSideroxylon obtusifolium(Roem. & Schult.) T.D. Penn on experimental burn wound model

Souza

Pierdoná

Macedo

et al. 2020

Preprint

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The larger number of plants, with therapeutic potential, popularly used in Northeastern Brazil is due to their easy access and the great Brazilian biodiversity. Previously, was demonstrated that the methanol fraction from Sideroxylon obtusifolium (MFSOL) promoted an anti-inflammatory and healing activity in excisional wounds. Thus, this work aimed to investigate the healing effects of MFSOL on human keratinocytes cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to investigate migration and proliferation of cell rates. Female Swiss mice were subjected to seconddegree superficial burn protocol and divided into four treatment groups: Vehicle (cream-base), 1.0% Silver Sulfadiazine (Sulfa), and 0.5% or 1.0% MFSOL cream (CrMFSOL). Samples were collected for quantification of the inflammatory mediators and histological analyses after 3, 7 and 14 days on evaluation. As result, MFSOL (50 μg/ml) stimulated HaCaT cells by increasing proliferation and migration rates.Moreover, CrMFSOL 0.5% attenuated myeloperoxidase (MPO) activity and also stimulated the release of IL-1β and IL-10, after 3 days with treatment. CrMFSOL 0.5% enhanced wound contraction, promoted tissue remodeling improvement and highest collagen production after 7 days, and VEGF release after 14 days. Therefore, MFSOL evidenced the stimulation of human keratinocyte (HaCaT) cells and improvements on wound healing via inflammatory modulation on burn injuries.

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“…In addition, a phytomodulatory galactomannan-based hydrogel has been successfully used to carrier latex proteases from C. procera in experimental excisional wound models. It was observed a synergic effect between both galactomannan and proteases macromolecules, enhancing the healing [48].…”

Section: Latex Proteasesmentioning

confidence: 95%

Plant Macromolecules as Biomaterials for Wound Healing

Sousa¹,

Mendes²,

Bermudez-Sierra³

et al. 2020

Wound Healing

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Natural biomolecules are increasingly relevant for biomedical applications and tissue engineering for being able to produce an effect on chemical signals, organization of cells, and restitution of extracellular matrix in lesioned tissues. In this chapter, we will address the potential of plant macromolecules, in particular, carbohydrates and proteins such as hemicelluloses and lectins. While lectins are mostly carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions, hemicelluloses are remarkably known by their ability to form viscous solutions even at low concentrations, which makes them an excellent candidate as vehicle to carry different sorts of biomolecules. Taking into account the complexity of the whole healing process, as an overlapping and coordinated cascade of events, most of the properties presented here by those materials may be of interest to the wound-care market.

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A phytomodulatory hydrogel with enhanced healing effects

Cited by 17 publications

References 27 publications

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Human keratinocyte (HaCaT) stimulation and healing effect of the methanol fraction from the decoction from leaf fromSideroxylon obtusifolium(Roem. & Schult.) T.D. Penn on experimental burn wound model

Plant Macromolecules as Biomaterials for Wound Healing

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