A pilot clinical study on the Traditional Korean Medicine treatment of Amyotrophic lateral sclerosis

Kim, Sung‐Chul; Na, Won-Min; Lim, Na-Ra; Lee, Dosang; Jang, Eun-Ha; Song, Bong‐Keun

doi:10.3831/kpi.2009.12.1.053

Cited by 8 publications

(15 citation statements)

References 8 publications

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“…All the studies were conducted in China and South Korea. There were 39 [ 4 , 8 , 13 , 18 , 19 , 24 – 26 , 29 – 34 , 39 – 41 , 44 – 58 , 60 – 65 , 68 ] and 20 [ 7 , 14 – 17 , 20 – 23 , 27 , 28 , 35 – 38 , 42 , 43 , 59 , 66 , 67 ] studies conducted in China and South Korea, respectively.…”

Section: Resultsmentioning

confidence: 99%

Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review

Suh

Seo

Jin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study aimed to analyze and summarize the existing evidence regarding herbal medicine treatments for amyotrophic lateral sclerosis (ALS). Studies on herbal medicine treatment in patients with ALS were searched within English, Chinese, Japanese, and Korean databases up to July 31, 2021. In the selected studies, we collected the following information: the first author, year of publication, country, language, study methodology, sample size, demographic characteristics of the study participants, disease duration, diagnostic criteria, treatment method, treatment periods, evaluation tools, results, and side effects. The organized data were classified and analyzed narratively. This study included 59 studies. The first clinical study on the effect of herbal medicine was published in 1995; moreover, most studies were conducted in China. Among the 59 selected studies, 47.5% were observational studies, including case reports and case series. Moreover, there was one meta-analysis. The El Escorial criteria were the most commonly used diagnostic criterion for ALS; moreover, the ALS functional rating scale was the most common evaluation tool. Buzhongyiqitang, Sijunzitangjiawei, and Jianpiyifeitang were the most commonly used herbal medicines, with anti-inflammatory, protein aggregation, and anti-oxidant effects. There remain evidence of gaps in the effectiveness of herbal medicine for ALS. To allow effective treatment of patients with ALS using herbal medicine, large-scale and rigorously designed high-quality clinical studies should be performed.

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Section: Resultsmentioning

confidence: 99%

Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review

Suh

Seo

Jin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Prior studies have shown that Mecasin, a herbal extract, has neuro-protective and anti-neuroinflammatory effects, and its safety has been proven in both in vitro and in vivo trials [ 8 – 14 ]; it has been shown to reduce the progression of ALS in Korean Medicine Clinics [ 6 , 7 ]. No previous randomized controlled trial has examined the effects of Mecasin for the treatment of ALS.…”

Section: Discussionmentioning

confidence: 99%

“…However, it severely decreased to 21.33 ± 9.93 at 8 months from discharge [ 6 ]. Another study showed that 30 days of the combined therapy led to a K-ALSFRS-R score increase from 28.42 ± 7.83 to 29.08 ± 7.99 [ 7 ]. Mecasin, also known as KCHO-1, a herbal extract from modified jakyakgamchobuja-tang , has shown neuro-protective and anti-neuroinflammatory effects and safety in both in vitro and in vivo trials [ 8 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mecasin treatment in patients with amyotrophic lateral sclerosis: study protocol for a randomized controlled trial

Kim

Son

et al. 2018

Trials

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BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes paralysis of limb, swallowing, and breathing muscles. Riluzole, the Food and Drug Administration-approved drug for ALS, provides minimal benefit, prolonging patient life by only 2–3 months. Previous studies have found a neuro-protective and anti-neuroinflammatory effect of Mecasin, with retrospective studies providing suggestive evidence for a beneficial effect of Mecasin. The aim of this study was to develop a protocol to determine the proper dosage of Mecasin.MethodsThis is a phase II-A, multi-center, randomized study with three arms. Thirty-six patients with ALS will be randomly assigned to one of three groups, each receiving the standard treatment with 100 mg of riluzole in addition to one of 1.6 g of Mecasin, 2.4 g of Mecasin, or a placebo. The Primary outcome is the Korean version of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised result after 12 weeks of treatment. Secondary outcomes include results of the Short Form Health Survey-8, Medical Research Council Scale, Visual Analogue Scale for Pain, Hamilton Rating Scale for Depression, Fatigue Severity Scale, Patient Global Impression of Change, pulmonary function test, forced expiratory volume in 1 s and its ratio to forced vital capacity, creatine kinase, and body weight. The frequencies of total adverse events and serious adverse events will be described and documented. The trial protocol has been approved by the Institutional Review Board of the Wonkwang University Gwangju and Sanbon Hospital (2016–5-4 and 2016–34-01, respectively). An Investigational New Drug status (30731) was granted by the Korea Food and Drug Administration.DiscussionThis trial will aim to identify the optimal dosage of Mecasin. Additionally, it will test the efficacy and safety of Mecasin in conjunction with standard treatment, riluzole, for alleviating the functional decline in patients with ALS.Trial registrationKorean National Clinical Trial Registry CRIS; KCT0001984. Registered on 28 July 2016.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2557-z) contains supplementary material, which is available to authorized users.

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“…한의학적 치료 증례보고 20 Ecklonia Cava Extract × 32,34,36,40) , 흉민과 단기 30,32,33) , 기침과 가래 26,32) , 발한 30) , 상열감 30,31) , 식 욕부진 42) , 무력감 37) 의 호전도 역시 보고되었다. …”

Section: )Alsssunclassified

A Literature Review of Korean Medical Studies of Amyotrophic Lateral Sclerosis (ALS)

Kim

et al. 2015

The Acupuncture

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A pilot clinical study on the Traditional Korean Medicine treatment of Amyotrophic lateral sclerosis

Abstract: ALS 3-5 symptomatic treatment supprotive 53 A pilot clinical study on the Traditional Korean Medicine treatment of Amyotrophic lateral sclerosis Kim Sung-chul, Na Won-min, Lim Na-ra, Lee Do-sang, Jang Eun-ha*, Song Bong-keun**

Cited by 8 publications

References 8 publications

Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review

Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review

Mecasin treatment in patients with amyotrophic lateral sclerosis: study protocol for a randomized controlled trial

A Literature Review of Korean Medical Studies of Amyotrophic Lateral Sclerosis (ALS)

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