A pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology

Oberweis, D.; Madelenat, P.; Nisolle, Michelle; Demanet, Etienne

doi:10.2147/nds.s92503

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Trace metals could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry, restoring a lost homeostasis and thus helping the body to recover its capacity for self-regulation [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

Soula,

Messas,

Aridhi

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

Soula,

Messas,

Aridhi

et al. 2024

Heliyon

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“…Zn is known as an inhibitor of MMPs, and increased levels of MMP-2 and MMP-9 were found in women suffering from endometriosis [ 94 , 100 ]. Moreover, high MMP-2 levels are correlated with advanced endometriosis [ 101 ], and few studies describe the clinical effectiveness of zinc supplementation [ 102 , 103 ].…”

Section: Trace Elements and Endometriosismentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

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Endometriosis is a chronic, estrogen-dependent, inflammatory condition that is defined as the presence of endometrial glands and stroma outside the uterine cavity. Despite the progress in research into the mechanisms leading to the development of endometriosis, its cause has not yet been established. It seems to be possible that the formation of oxidative stress may be one of the main causes of the development of endometriosis. There is much research that studies the potential role of trace elements in the appearance of endometrial-like lesions. Most studies focus on assessing the content of selected trace elements in the blood, urine, or peritoneal fluid in women with endometriosis. Meanwhile, little is known about the content of these elements in endometrial-like implants, which may be helpful in developing the theory of endometriosis. Investigations that are more comprehensive are needed to confirm a hypothesis that some trace elements play a role in the pathomechanism of endometriosis.

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“…Although the etiology of endometriosis needs to be clarified and many factors (e.g., smoking, alcohol consumption) are involved in its development, research in last years focused on the possible role of ROS [99,[108][109][110]. In view of the above, there are only few studies supporting clinical effectiveness of supplementation of zinc and other antioxidants in endometriosis [108,111], but to provide strong evidence more randomized, placebo-controlled trials are needed.…”

Section: Zinc and Endometriosismentioning

confidence: 99%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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A pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology

Cited by 4 publications

References 41 publications

Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

Brief Review of Endometriosis and the Role of Trace Elements

The Role of Zinc in Selected Female Reproductive System Disorders

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