A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome

Hashempur, Mohammad Hashem; Lari, Zeinab Nasiri; Ghoreishi, Parissa Sadat; Daneshfard, Babak; Ghasemi, Mohammad; Homayouni, Kaynoosh; Zargaran, Arman

doi:10.1016/j.ctcp.2015.08.001

Cited by 36 publications

(24 citation statements)

References 30 publications

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“…These pharmacological properties suggest that the plant might be a valuable therapeutic option for the prophylaxis and treatment of various diseases, including inflammation, ulcers, sedation, hemorrhoids, cough, stomach ache, pharyngitis, and rheumatic pain [14]. Previous phytochemical investigations on M. chamomilla have led to the isolation of essential oil, flavonoids, terpenoids, and coumarins [15–19]. Among these chemical compositions, flavonoids are the main active constituents present in the plant, which exhibited anxiolytic and antidepressant activity [20, 21].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC‐UV

Dong

Wei

Yin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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A simple and sensitive HPLC-UV method has been developed for the simultaneous determination of quercetin, luteolin, and apigenin in rat plasma after oral administration of Matricaria chamomilla L. extract. The flow rate was set at 1.0 ml/min and the detection wavelength was kept at 350 nm. The calibration curves were linear in the range of 0.11–11.36 μg/ml for quercetin, 0.11–11.20 μg/ml for luteolin, and 0.11–10.60 μg/ml for apigenin, respectively. The intraday and interday precisions (RSD) were less than 8.32 and 8.81%, respectively. The lower limits of quantification (LLOQ) of the three compounds were 0.11 μg/ml. The mean recoveries for quercetin, luteolin, and apigenin were 99.11, 95.62, and 95.21%, respectively. Stability studies demonstrated that the three compounds were stable in the preparation and analytical process. The maximum plasma concentration (Cmax) was 0.29 ± 0.06, 3.04 ± 0.60, and 0.42 ± 0.10 μg/ml, respectively. The time to reach the maximum plasma concentration (Tmax) was 0.79 ± 0.25, 0.42 ± 0.09, and 0.51 ± 0.13 h, respectively. The validated method was successfully applied to investigate the pharmacokinetics study of quercetin, luteolin, and apigenin in rat plasma after oral administration of M. chamomilla extract.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC‐UV

Dong

Wei

Yin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…It also has acaricidal properties. In several animal studies, anxiolytic ( 18 ), antimutagenic and cholesterol-lowering, wound healing ( 19 ), and antidiabetic properties ( 20 ) for this plant were suggested. In in vitro studies, chamomile was demonstrated to possess modest antimicrobial and antioxidant properties ( 21 ) and strong antiplatelet and anticarcinoma properties.…”

Section: Introductionmentioning

confidence: 99%

A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)

Miraj¹,

Alesaeidi²

2016

Electron physician

109

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IntroductionMatricaria recuitta chamomilla is a plant that grows and is cultivated in some parts of Iran. The aim of this study was to overview the therapeutic effects of this valuable plant. This systematic review was aimed to introduce Matricaria recuitta chamomile, its chemical compounds, and its traditional usages.MethodsThis review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 87 references. In this study, 69 studies were accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Matricaria recuitta chamomilla L and dated mainly from the year 1990 to 2016]. The search terms were “Matricaria recuitta chamomilla L.,” “therapeutic properties,” “pharmacological effects.”ResultIt is commonly used for its antioxidant, antimicrobial, antidepressant, anti-inflammatory, antidiarrheal activities, angiogenesis activity, anticarcinogenic, hepatoprotective, and antidiabetic effects. Besides, it is beneficial for knee osteoarthritis, ulcerative colitis, premenstrual syndrome, and gastrointestinal disorders.ConclusionMatricaria recuitta chamomilla L. is widely used for therapeutic and nontherapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, oil, and leaves demand further studies about other useful and unknown properties of this multipurpose plant.

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“… 43 There is some evidence that chamomile oil improves severe carpal tunnel syndrome. 44 Subsequent trials will determine whether other topical combinations, proposed by complementary medicine including flax seed oil, may be effective in severe cases and reduce related surgeries and their potential complications and risks.…”

Section: Discussionmentioning

confidence: 99%

A Topical Gel From Flax Seed Oil Compared With Hand Splint in Carpal Tunnel Syndrome: A Randomized Clinical Trial

Setayesh

Sadeghifar

Nakhaee

et al. 2016

J Evid Based Complementary Altern Med

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This study compared the therapeutic effect of flax seed oil topical gel and hand splint in the treatment of carpal tunnel syndrome. This study was a randomized clinical trial. Forty-nine patients, 96 hands, with mild to moderate idiopathic carpal tunnel syndrome were divided into 2 groups randomly. One group was treated by topical gel and the other group by hand splint. Intensity of symptoms and function before and after intervention was measured via Boston Carpal Tunnel Questionnaire. After intervention, the ANCOVA showed a significant difference between the symptom and function scores of the 2 groups. In both cases, recovery was higher in the gel group (P < .001). The topical use of flax seed oil gel is more effective in the improvement of symptoms and function of patients with mild to moderate carpal tunnel syndrome as compared with hand splint, and it can be introduced as an effective treatment.

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A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome

Cited by 36 publications

References 30 publications

Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC‐UV

Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC‐UV

A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)

A Topical Gel From Flax Seed Oil Compared With Hand Splint in Carpal Tunnel Syndrome: A Randomized Clinical Trial

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