A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring

Sharma, Sanjiv; El-Laboudi, Ahmed; Reddy, Monika; Jugnee, Narvada; Sivasubramaniyam, Sujan; Sharkawy, Mohamed El; Georgiou, Pantelis; Johnston, Desmond G.; Oliver, Nick; Cass, Anthony E. G.

doi:10.1039/c8ay00264a

Cited by 105 publications

(96 citation statements)

References 33 publications

(39 reference statements)

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“…The biggest challenge in translating microneedle array based electrochemical sensors and microneedle arrays drug delivery into a closed-loop control system is the accuracy of the MNA sensors especially during the initial phase of monitoring, when the sensors baseline has not reached a steady state. Sensor warm up time for electrochemical sensors has been reported in the literature (Sharma 2018). Addressing this issue will impact the further development of MNA theranostic closed loop systems.…”

Section: Resultsmentioning

confidence: 99%

“…MNAs as electrochemical biosensors for continuous glucose monitoring has already been tested in Type 1 diabetics, demonstrating their safety, tolerability and performance. (Sharma, 2018)…”

Section: Concept Of Microneedle Arrays Platform For Future Theranostimentioning

confidence: 99%

“…In a human pilot study conducted in healthy volunteers and participants with Type 1 diabetes, it has been established that the occurrence of infection, bleeding and pain have not been reported, and these MNA have been reportedly tolerated very well in both healthy volunteers and participants with Type 1 diabetes studies. (Sharma, 2018) So far, MNAs have been modified to fabricate electrochemical sensors and used for monitoring metabolites (glucose and lactate), drugs such as theophylline and penicillin (Rawson 2017). This is done either entrapping the molecular recognition element (in the case of glucose sensors it is the enzyme glucose oxidase) either in a polymer such as electropolymerised polyphenol (Sharma, 2016) or in hydrogels on platinum or graphene (Lee, 2016) coated MNAs.…”

Section: Insert Figure 3 Herementioning

confidence: 99%

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Microneedle Array‐Based Platforms for Future Theranostic Applications

et al. 2019

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Theranostics involves finding the biomarkers of a disease, fighting them through site specific drug delivery and following them for prognosis of the disease. Microneedle array technology has been used for drug delivery and extended for continuous monitoring of analytes present in the skin compartment. We envisage the use of microneedle arrays for future theranostic applications. The potential of combining microneedle array‐based drug delivery and diagnostics as part of closed‐loop control system for the management of diseases and delivery of precision drugs in individual patients is reported in this paper.

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Section: Resultsmentioning

confidence: 99%

“…MNAs as electrochemical biosensors for continuous glucose monitoring has already been tested in Type 1 diabetics, demonstrating their safety, tolerability and performance. (Sharma, 2018)…”

Section: Concept Of Microneedle Arrays Platform For Future Theranostimentioning

confidence: 99%

Section: Insert Figure 3 Herementioning

confidence: 99%

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Microneedle Array‐Based Platforms for Future Theranostic Applications

et al. 2019

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“…The first human data from solid microneedle CGM for durations of up to 24 h have been reported [34]. Results reported user acceptability, with no adverse events and MARD accuracy of 9%, with >94% of the data points in the A and B zones of the Clarke error grid [34].…”

Section: Microneedlesmentioning

confidence: 99%

Is it possible to constantly and accurately monitor blood sugar levels, in people with Type 1 diabetes, with a discrete device (non‐invasive or invasive)?

2019

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Real‐time continuous glucose monitors using subcutaneous needle‐type sensors continue to develop. The limitations of currently available systems, however, include time lag behind changes in blood glucose, the invasive nature of such systems, and in some cases, their accuracy. Non‐invasive techniques have been developed, but, to date, no commercial device has been successful. A key research priority for people with Type 1 diabetes identified by the James Lind Alliance was to identify ways of monitoring blood glucose constantly and accurately using a discrete device, invasive or non‐invasive. Integration of such a sensor is important in the development of a closed‐loop system and the technology must be rapid, selective and acceptable for continuous use by individuals. The present review provides an update on existing continuous glucose‐sensing technologies, and an overview of emergent techniques, including their accuracy and limitations.

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“…When combined with mobile devices, wearable health monitors can acquire, manipulate, store, and transmit data inexpensively compared to conventional solutions 4. At the same time, flexible and stretchable devices could provide unobtrusive and continuous monitoring of health without sacrificing comfort 5–12…”

Section: Introductionmentioning

confidence: 99%

Stretchable Composite Acoustic Transducer for Wearable Monitoring of Vital Signs

Cotur

Kasimatis

Kaisti

et al. 2020

Adv Funct Materials

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A highly flexible, stretchable, and mechanically robust low-cost soft composite consisting of silicone polymers and water (or hydrogels) is reported. When combined with conventional acoustic transducers, the materials reported enable high performance real-time monitoring of heart and respiratory patterns over layers of clothing (or furry skin of animals) without the need for direct contact with the skin. The approach enables an entirely new method of fabrication that involves encapsulation of water and hydrogels with silicones and exploits the ability of sound waves to travel through the body. The system proposed outperforms commercial, metal-based stethoscopes for the auscultation of the heart when worn over clothing and is less susceptible to motion artefacts. The system both with human and furry animal subjects (i.e., dogs), primarily focusing on monitoring the heart, is tested; however, initial results on monitoring breathing are also presented. This work is especially important because it is the first demonstration of a stretchable sensor that is suitable for use with furry animals and does not require shaving of the animal for data acquisition.

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A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring

Abstract: Although subcutaneously implanted continuous glucose monitoring (CGM) devices have been shown to support diabetes self-management, their uptake remains low due to high costs and poor accuracy and precision arising from their invasiveness.

Cited by 105 publications

References 33 publications

Microneedle Array‐Based Platforms for Future Theranostic Applications

Microneedle Array‐Based Platforms for Future Theranostic Applications

Is it possible to constantly and accurately monitor blood sugar levels, in people with Type 1 diabetes, with a discrete device (non‐invasive or invasive)?

Stretchable Composite Acoustic Transducer for Wearable Monitoring of Vital Signs

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