A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection

Aboshady, Ibrahim; Raad, Issam; Shah, Aamir S.; Vela, Deborah; Dvorak, Tanya; Safi, Hazim J.; Buja, L. Maximilian; Khalil, Kamal

doi:10.1016/j.jvs.2012.02.008

Cited by 25 publications

(23 citation statements)

References 41 publications

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“…Furthermore, as soon as the antibiotic contained in the device is exhausted, antibiotic delivery stops. Antibioticcoated surfaces have also been studied in animal and clinical studies of urinary catheters, endotracheal tubes, orthopedic devices, and vascular grafts, with contrasting clinical benefits (205)(206)(207)(208)(209)(210)(211)(212)(213)(214)(215)(216). Thus, development of a coated surface that prevents bacterial colonization for a long time remains a challenge.…”

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Lebeaux

Ghigo

Beloin

2014

Microbiol Mol Biol Rev

1,051

862

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International audienceSurface-associated microbial communities, called biofilms, are present in all environments. Although biofilms play an important positive role in a variety of ecosystems, they also have many negative effects, including biofilm-related infections in medical settings. The ability of pathogenic biofilms to survive in the presence of high concentrations of antibiotics is called "recalcitrance" and is a characteristic property of the biofilm lifestyle, leading to treatment failure and infection recurrence. This review presents our current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved our capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections

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Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Lebeaux

Ghigo

Beloin

2014

Microbiol Mol Biol Rev

1,051

862

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“…Even though rare, it may be possible to reduce the frequency of the prosthetic graft infections further by soaking the graft in antibiotic solution before implantation. 30 Graft wrapping with vascularized tissue such as omentum is rarely performed in first-time, noninfected implants but has been used successfully in the case of infected graft material in an attempt to control the infection rather than explanting the graft. 31,32 …”

Section: Discussionmentioning

confidence: 99%

A Tale of Three Surgeries: Management of a Massive Recurrent Mycotic Aortic Pseudoaneurysm

Henley

Ikonomidis

Kolarczyk

et al. 2018

Journal of Cardiothoracic and Vascular Anesthesia

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“…Fungal infections caused especially by Candida species are rare but important pathogenetic factors of AGI. The increase in methicillin-resistant Staphylococcus aureus (MRSA) has become a problem rising in the past few years (14,15).…”

Section: Pathogenesismentioning

confidence: 99%

Management of aortic graft infections – the present strategy and future perspectives

Treska¹,

Certík²,

Moláček³

2016

BLL

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Aortic graft infections (AGI) are serious complications of open and endovascular types of surgery with an incidence rate of 0.6-3 %. AGI are associated with 30-60 % perioperative mortality and 40-60 % morbidity rate with limb amputation rates between 10 % and 40 %. The economic cost of AGI is substantial. At the time of aortic reconstruction, almost 90 % of patients have one or more predisposing factors for AGI. The diagnosis is based on clinical symptomatology, laboratory markers, microbial cultures, and imaging modalities. The general principle of surgical treatment lies in the removal of infected graft, debridement of infected periprosthetic tissues, and vascular reconstruction by in situ or extra-anatomic bypass with long-term antibiotic therapy. The conservative treatment is used only for selected patients with endograft infection. This review summarizes the current knowledge about the incidence, predisposing factors, etiology, diagnosis, treatment options, and prevention of aortic vascular graft and endograft infections. With the growing number of endovascular procedures we can expect more cases of infected aortic endografts in patients with severe comorbidities in the near future, where the recent radical surgical approach (graft excision, debridement, and new revascularization) cannot be used. Therefore the less invasive, sophisticated and individualized treatment strategies will have to be used in search of the best therapeutic approach to each specifi c patient (Fig. 4, Ref. 82). Text in PDF www.elis.sk.

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A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection

Cited by 25 publications

References 41 publications

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

A Tale of Three Surgeries: Management of a Massive Recurrent Mycotic Aortic Pseudoaneurysm

Management of aortic graft infections – the present strategy and future perspectives

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