A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy under endosonographic guidance

Konda, Vani J.; Meining, Alexander; Jamil, Laith H.; Giovannini, Marc; Hwang, Joo Ha; Wallace, Michael B.; Chang, Kenneth J.; Siddiqui, Uzma D.; Hart, John; Lo, Simon K.; Saunders, Michael D.; Aslanian, Harry R.; Wroblewski, Kirsten; Waxman, Irving

doi:10.1055/s-0033-1344714

Cited by 200 publications

(161 citation statements)

References 9 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…They found that the presence of epithelial villous structures correlated with pancreatic cystic neoplasms with a specificity of 100%, but a low sensitivity of 59% (P = 0.004). 31,43 The complication rate was 9%, including two cases of pancreatitis and three with intracystic bleeding. 43 Napoléon et al 44 implemented a pilot study to ascertain diagnostic criteria for serous cystadenomas using nCLE imaging in 31 patients with single pancreatic cystic lesions.…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 97%

“…31,43 The complication rate was 9%, including two cases of pancreatitis and three with intracystic bleeding. 43 Napoléon et al 44 implemented a pilot study to ascertain diagnostic criteria for serous cystadenomas using nCLE imaging in 31 patients with single pancreatic cystic lesions. Their study demonstrated data similar to Konda and colleagues with a specificity of 100% and sensitivity of 69% for the presence of superficial vascular network pattern.…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 97%

“…42 Two patients required hospitalization for post-procedural pancreatitis, possibly related to larger EUS-FNA needle size. 32,42 Konda et al 43 followed up with a larger multicenter study in the Pancreas with Endosonography of Cystic Tumors (INSPECT) evaluating the diagnostic capability and safety of nCLE in pancreatic cystic neoplasms. They found that the presence of epithelial villous structures correlated with pancreatic cystic neoplasms with a specificity of 100%, but a low sensitivity of 59% (P = 0.004).…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

“…44 This data suggests nCLE may serve as an adjunct to EUS in order to increase the diagnostic accuracy of neoplastic pancreatic cysts, but more and larger studies are needed. 35,[42][43][44] EUS-FNA vs EUS-FNB in solid pancreatic lesions EUS-FNA was developed in the early 1990s as a means to aid EUS imaging in the diagnosis of pancreatic lesions via tissue sampling. 6,11,45 It has since become standard of care to obtain EUS-FNA of SPL based on its cytological diagnostic sensitivity exceeding 80% in cases without underlying chronic pancreatitis.…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

See 3 more Smart Citations

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Luthra

Mishra

2017

Int J Gastrointest Interv

View full text Add to dashboard Cite

show abstract

Section: Confocal Laser Endomicroscopymentioning

confidence: 97%

Section: Confocal Laser Endomicroscopymentioning

confidence: 97%

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

See 2 more Smart Citations

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Luthra

Mishra

2017

Int J Gastrointest Interv

View full text Add to dashboard Cite

show abstract

“…The proximal scanning method is used in the Cellvizio system (Mauna Kea Technologies, France) and several variations of this system are now available [46][47][48] , with the thinnest probe offered by Mauna Kea Technologies having an outer diameter of 0.85 mm (REF. 49). Simple non-scanning endomicroscopes, using a fibre-bundle to flood illuminate the sample and then collect images, have also been applied to the gastrointestinal tract 50,51 but not commercialized.…”

Section: Microbiota Changesmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

Self Cite

View full text Add to dashboard Cite

| Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques -which can provide minimally invasive or noninvasive alternatives to biopsy -could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care. Members of the board and experts met to discuss the horizon scan in London, UK, in November 2015 and San Francisco, USA, in February 2016. Literature searches were performed using Web of Science, as well as through the advice of the advisory board and experts. The results of the horizon scan are presented in this Consensus Statement, which entails a review of EED, a discussion of technologies deemed relevant to EED (based on literature searches and the opinions of the advisory board and experts), and a series of recommendations for the future application of the rele vant technologies to the study and diagnosis of EED. In the Recommendations section, each technology has been assessed according to its suitability for application to EED and this assessment includes an evaluation of the cost, invasiveness and appropriateness for developing countries of each device and/or technique. This assessment was performed in a qualitative manner based on currently available information (for example, the present cost and size of the devices) and the opinions of the authors as to feasible future develop ment. Technique suitability for use in developing countries was determined in a qualitative manner after consideration of the need for advanced infrastructure and high levels of training for either system use or data analysis. Probable deployment time scales have also been assigned to each technique based on the current states of development and the degree of valid ation work that will be required before application to EED. These timescales have been tentatively defined as short-term (suitable for deployment immediately or within ~1 year), mediumterm (suit able for deployment within ~1-3 years) and long-term (suitable for deployme...

show abstract

Confocal Laser Microscopy

Neumann

Kießlich

2015

Yamada' S Textbook of Gastroenterology

View full text Add to dashboard Cite

A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy under endosonographic guidance

Abstract: These preliminary data suggested that nCLE has a high specificity in the detection of PCN, but may be limited by a low sensitivity. The safety of nCLE requires further evaluation.

Cited by 200 publications

References 9 publications

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Confocal Laser Microscopy

Contact Info

Product

Resources

About