A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

Alves, J. C.; Santos, Ana; Jorge, Patrícia; Lavrador, Catarina; Carreira, L. Miguel

doi:10.3389/fvets.2020.512523

Cited by 15 publications

(13 citation statements)

References 43 publications

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“…A single administration was carried out, on day 0, following a protocol previously described. 27,28 Ultrasound guidance was available when required.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

Topics in Companion Animal Medicine

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“…A single administration was carried out, on day 0, following a protocol previously described. 27,28 Ultrasound guidance was available when required.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

Topics in Companion Animal Medicine

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“…Hips were classified according to the Orthopedic Foundation for Animals hip grading scheme at the initial evaluation, on day 0 (treatment day) [21]. The procedure for hip IA administrations has been described previously [40]. Dogs were placed in lateral recumbency with the joint to be accessed dorsal.…”

Section: Methodsmentioning

confidence: 99%

Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis

Alves

Santos²,

Jorge³

2021

BMC Vet Res

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Background Osteoarthritis (OA) is the most commonly diagnosed joint disease in companion animals, and hip OA is commonly diagnosed in the canine population. The use of platelet-rich plasma has gained increasing interest for the treatment of musculoskeletal conditions in companion animals. To evaluate the effect of the intra-articular administration of platelet-rich plasma in police working dogs with bilateral hip OA compared to a control group, twenty dogs were assigned to a control group (CG, n = 10) or treatment group (PG, n = 10), using the statistical analysis software. PG received two intra-articular administrations of platelet-rich plasma, 14 days apart, while CG received an intra-articular administration of saline, in the same moments. Response to treatment was determined with the Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index, and Hudson Visual Analogue Scale, before treatment, + 8, + 15, + 30, + 60, + 90, + 120, 150, and + 180 days after initial treatment. Kaplan-Meier estimators were conducted and compared with the log-rank test. Cox proportional hazard regression analysis was performed to determine treatment survival, p < 0.05. Results The sample comprised 20 animals of both sexes (male n = 12, female n = 8), with a mean age of 8.4 ± 2.4 years and a bodyweight of 31.5 ± 5.7 kg. Joints were classified as moderate (13) and severe (7) according to the Orthopedic Foundation for Animals grading scheme. No differences were found between groups at the initial evaluation. Better results with the majority of scores were observed in the PG, in some cases lasting up to the last evaluation moment. Kaplan-Meier estimators showed that PG produced longer periods with better results in all scores compared to CG. Treatment was the covariate influencing all scores in the Cox regression analysis. OFA hip score also influenced two dimensions of the Canine Orthopedic Index. Conclusion The intra-articular administration of platelet-rich plasma can improve pain and functional scores of police working dogs with bilateral hip OA, compared with a control group. Its effects lasted for significantly longer periods, and treatment was the main covariate affecting the improvements observed.

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“…Still, and for this reason, a popular approach is the combined administration of corticosteroid and another substance, such as hyaluronan. This combined use of two substances provides a rapid onset of action, obtained from the corticosteroid, associated with a longer effect and decreased possibility of side effects, obtained from hyaluronan [32][33][34]. Similarly, there is a potential benefit in combining corticosteroids and BCS in a single IA administration.…”

Section: Introductionmentioning

confidence: 99%

A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

BMC Vet Res

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Background Osteoarthritis represents a significant welfare problem for many dogs, with limited therapeutic options other than palliative pain control. To evaluate the effect of the intra-articular administration of blood cell secretome and triamcinolone, 15 dogs with bilateral hip osteoarthritis were randomly assigned to a blood cell secretome (BCSG, n = 5), triamcinolone (TG) or their combination group (BCS + TG, n = 5). BCSG received a single intra-articular administration of 3 ml of blood cell secretome, TG 0.5 ml of triamcinolone acetonide 40 mg/ml, and BCS + TG received the combined products. The volume to administrate was corrected to 3.5 ml with saline. On days 0, 8, 15, 30, 60, 90, 120, 150, and 180, a copy of the Canine Brief Pain Inventory (divided into pain interference score—PIS and Pain Severity Score—PSS), Liverpool Osteoarthritis in Dogs (LOAD), Hudson Visual Analogue Scale (HVAS), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) was completed. Results were analyzed with the Kruskal–Wallis test and the Kaplan–Meier estimators were conducted and compared with the Log Rank test, p < 0.05. Results Animals in the sample had a mean age of 9.0 ± 2.9 years and a bodyweight of 28.8 ± 4.1 kg. Hips were classified as moderate (8) and severe (7) osteoarthritis. No differences were found between groups at T0 regarding considered evaluations. Significant differences were observed between groups in pain scores from + 8d- + 150d, with BCS + TG exhibiting better results. The same was observed for HVAS and LOAD, from + 8d- + 120d. Improvements were also observed in several dimensions of the COI. Kaplan–Meier estimators showed that BCS + TG produced longer periods with better results, followed by BCSG and TG. Conclusion The intra-articular administration of blood cell secretome improved the clinical signs and scores of several clinical metrology instruments in dogs with hip OA, particularly when combined with triamcinolone. Further studies are required.

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A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

Abstract: Objectives: To describe and compare the use and effectiveness of a single intra-articular injection (IA) of triamcinolone acetonide (TA), hyaluronan (HA), and a combination of both (TA+HA) in police working dogs with natural occurring hip osteoarthritis (OA).

Cited by 15 publications

References 43 publications

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis

A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis

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