A pioneer in neuropathology: Alix Joffroy (1844–1908), J.-M Charcot’s pupil

Tiberghien, Denis

doi:10.1016/j.nmd.2009.10.004

Cited by 4 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coincidentally described in a French article authored by Jean‐Martin Charcot and Pierre Marie () and in England by Howard Henry Tooth, in his MD thesis at Cambridge University (Lidge and Fremont, ), Charcot‐Marie‐Tooth disease (CMT) is a condition typically described as peroneal muscle atrophy consequent to an hereditary neuropathy (Firth and Hurst, ; Wiszniewski et al, ). Initially, the condition was usually conflated with muscular dystrophy, sharing a common clinical feature of muscle atrophy (Warrington, ;Tiberghien, ), although Charcot himself apparently argued that it was an hereditary neuropathy. Subsequently, with ensuing development in clinical and genetic knowledge of both the hereditary neuropathies and myopathies, the emergence of a clearer distinction between the two took place (Lidge and Fremont, ).…”

Section: Introductionmentioning

confidence: 99%

Charcot‐Marie‐Tooth 1A: A narrative review with clinical and anatomical perspectives

McGrath

2015

Clinical Anatomy

View full text Add to dashboard Cite

Charcot-Marie-Tooth 1A (CMT1A) is regarded as the most common hereditary peripheral neurodegenerative disorder. This narrative review highlights perspectives around the historically well-established and characteristic anatomical manifestations of CMT1A seen in the feet, legs and hands, in addition to a clinical diagnosis that may be confirmed by electrophysiology, genetic or molecular markers together with the presence of a typical family history. A less well-known perspective is the potential for systemic manifestations and wider complication. The condition is characterised by a progressive clinical picture with unmistakable anatomical and neurological features that have been described since the late 19th century. There remains no cure although supportive, rehabilitative, and surgical regimes may provide helpful management or amelioration of symptoms. Most recently, the emergence of a pleotherapeutic approach suggests distinct promise. Future research focused on a detailed elucidation of the underlying molecular mechanisms underpinning myelin and axonal function may eventually hold the key to successful treatment of CMT1A. Genetic modification would potentially present a cure. Clin. Anat. 29:547-554, 2016. © 2015 Wiley Periodicals, Inc.

show abstract

Section: Introductionmentioning

confidence: 99%

Charcot‐Marie‐Tooth 1A: A narrative review with clinical and anatomical perspectives

McGrath

2015

Clinical Anatomy

View full text Add to dashboard Cite

show abstract

“…Starting on 20 September 1870, the Third and Fourth German Armies, under the command of the Royal Princes of Saxony and Prussia, laid siege to Paris. 1 On 4 September 1870 Gambetta, Jules Favre and Jules Ferry proclaimed the Republic at Paris' Hotel de Ville after Emperor Napoleon III was imprisoned at Sedan. A Government of National Defence presided over by General Trochu had been constituted.…”

Section: Introductionmentioning

confidence: 99%

“…Joffroy was a pioneer in neuropathology. 4 In 1869 with Charcot he described the alteration in anterior horn cells in progressive spinal muscular atrophy, a variety of motor neurone disease. In 1870 he repeated with Duchenne de Boulogne the demonstration of labio-glosso-laryngo paralysis.…”

Section: Introductionmentioning

confidence: 99%

The letters of Alix Joffroy (1844–1908), a medical intern at Lariboisière’s Hospital at the time of the Commune of Paris

Tiberghien

2014

J Med Biogr

View full text Add to dashboard Cite

Since opening in 1848, Lariboisière's Hospital was strongly associated with the history of Paris and especially with the terrible days of the siege of Paris and the fights of the Commune. On the day after the surrender, Alix Joffroy wrote his first letter to his mother. He described the events as he experienced them, expressing his feelings about the causes of this political and military disaster and his experience there as an intern. Some weeks after the defeat of France by the Prussians, humbled Parisians attacked governmental troops. From March to May 1871 an improvised insurrectionary movement, The Commune of Paris, had taken power in the capital During the Bloody Week from 21 to 28 May 1871; this movement was suppressed by the Versaillaise Army. In his second letter, Joffroy related with great realism the tooth and nail fighting at the barricades and then the savage repression by the Army of the Communards around Lariboisière's Hospital. Two letters preciously preserved by Alix Joffroy's descendants give this man's unique direct account of a tragic period of the 19th century.

show abstract

The Chair of Mental and Brain Diseases: Charcot’s Pupils – Benjamin Ball, Alix Joffroy and Gilbert Ballet

Tiberghien

2010

Frontiers of Neurology and Neuroscience

View full text Add to dashboard Cite

Benjamin Ball (1833-1893), Alix Joffroy (1844-1908) and Gilbert Ballet (1853-1916) were three pupils of the great Charcot (1825-1893). They were successive holders of the chair for mental illness and encephalon at its creation in 1877 until the First World War: Benjamin Ball from 1877 to 1893, Alix Joffroy from 1893 to 1908, and Gilbert Ballet from 1908 to 1916. After describing the context surrounding the creation of this chair and the choice of its representative and successors, we will examine their neurological work on the brain derived from a method influenced by a current of thought careful to list the symptoms of the disease and to look for the anatomical causes in the brain. The renowned 19th century French neurologist Jean-Martin Charcot was a huge influence. With their acquired experience and progress in the fields of morphology and histology and cerebral cortex functioning, they greatly contributed to the evolution of neurological, clinical anatomical and psychological-physiological findings--thus allowing certain pathologies to be considered as organic diseases rather than neurotic symptoms--while all the time recognizing the importance of the cortical cell in mental illness.

show abstract

A pioneer in neuropathology: Alix Joffroy (1844–1908), J.-M Charcot’s pupil

Cited by 4 publications

References 4 publications

Charcot‐Marie‐Tooth 1A: A narrative review with clinical and anatomical perspectives

Charcot‐Marie‐Tooth 1A: A narrative review with clinical and anatomical perspectives

The letters of Alix Joffroy (1844–1908), a medical intern at Lariboisière’s Hospital at the time of the Commune of Paris

The Chair of Mental and Brain Diseases: Charcot’s Pupils – Benjamin Ball, Alix Joffroy and Gilbert Ballet

Contact Info

Product

Resources

About