A Planar Schiff Base Platinum(II) Complex: Crystal Structure, Cytotoxicity and Interaction with DNA

Schiff Base Metal Complexes as Anticancer Agents

“…Cell cycle evaluation indicated that the complex prompted apoptosis and G1-phase arrest in A549 cells. The outcome confirmed that the complex could suppress the proliferation and viability of a549 cells by colony formation assay [26].…”

“…Platinum(II) Schiff base ligand that derived from 5-chlorosalicylaldehyde and o-phenylenediamine was synthesized and charcterized ( Fig. 17) [26]. The in vitro cytotoxicities of metal chelates had been investigated through microculture tetrozolium (MTT) assay against seven human tumor cell lines.…”

Crystal structure oftrans-dichlorido(4-nitroaniline-κN1)(piperidine-κN)platinum(II)

“…The title compound is one of many complexes which have been synthesized for the purpose of potential medical applications (Klein & Hambley, 2009;Wilson & Lippard, 2014;Peng et al, 2014). It is notable that according to the procedure used for the synthesis of complexes of the type cis-[PtCl 2 (piperidine)(another amine)] (piperidine hereafter denoted Pip) (Dinh & Da, 2003;Nguyen Thi Thanh et al, 2014), the reaction between K[PtCl 3 (Pip)] and p-nitroaniline under appropriate conditions gave no cis complex, as expected, but instead gave the trans-[PtCl 2 (p-nitroaniline)(Pip)] derivative, (I).…”

Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes

“…Schiff base metal complexes have received special attention because of their biological activity. Many Schiff bases are known to be medicinally important and are used to design medicinal compounds [5,6]. A wide range of Schiff bases have been synthesized and their complexation behaviour studied in recent years.…”

“…4-Aminoantipyrine derivatives are very important in the field of coordination complexes and also these compounds are reported to exhibit analgesic and anti-inflammatory effects, antiviral, antibacterial, anti-cancer and herbicidal activities. [8][9][10][11][12][13]. In view of the above applications and importance, in the present paper we report the synthesis, characterization, and biological activity of platinum complexes with the Schiff bases derived from 4-aminoantipyrene and substituted benzaldehydes.…”