2011
DOI: 10.1111/j.1750-2659.2011.00295.x
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A plant‐based system for rapid production of influenza vaccine antigens

Abstract: Please cite this paper as: Shoji et al. (2011) A plant‐based system for rapid production of influenza vaccine antigens. Influenza and Other Respiratory Viruses 6(3), 204–210. Background  Influenza virus is a globally important respiratory pathogen that causes a high degree of annual morbidity and mortality. Significant antigenic drift results in emergence of new, potentially pandemic, virus variants. The best prophylactic option for controlling emerging virus strains is to manufacture and administer pandemic v… Show more

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Cited by 96 publications
(72 citation statements)
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“…Influenza type A can be subtyped by different variants of NA (1-9) and HA (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), which differ from each other in virulence, host specificity and binding of HAs subtypes on human and/or avian glycan receptors [19][20][21][22][23][24]. Specific HA-glycan affinity has been exploited as the basis for isolation of various types of influenza viruses [25].…”
Section: Resultsmentioning
confidence: 99%
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“…Influenza type A can be subtyped by different variants of NA (1-9) and HA (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), which differ from each other in virulence, host specificity and binding of HAs subtypes on human and/or avian glycan receptors [19][20][21][22][23][24]. Specific HA-glycan affinity has been exploited as the basis for isolation of various types of influenza viruses [25].…”
Section: Resultsmentioning
confidence: 99%
“…These days are characterized by rapid population growth, international trade and globalization, and for this reason the risk of influenza pandemics looms larger and larger [1]. Influenza is one of the most frequently occurring respiratory diseases, which causes approximately 500,000 deaths every year.…”
Section: Introductionmentioning
confidence: 99%
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“…It has been found to be extremely versatile for genetic manipulation and tissue culture research (Ganapathi et al, 2004). Several recombinant proteins have been expressed in transgenic tobacco as bioreactors for the production of commercially important pharmaceutical molecules (Shoji et al, 2012). Many immunogenic proteins have been synthesised in tobacco and several plant-based vaccine candidates have demonstrated efficacy against a large number of human and animal pathogens after oral administration (Daniell et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…HA-based influenza vaccines have successfully been developed over the last decade from many sources, including bacterial 17 and plant expression systems. [18][19][20] Regardless of the source, a significant disadvantage is that HA protein is not robustly immunogenic on its own. Most formulations require high doses, repeat immunization, or adjuvant formulation for effective and protective immune activation in animal models 18,21 and in clinical trials.…”
Section: Introductionmentioning
confidence: 99%