2003
DOI: 10.1159/000068119
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A Point Mutation in the First Splice Donor Leads to Reduced Oncogenic Properties of the Adenovirus Serotype 12 E1A Gene

Abstract: Cells transformed by proteins of early regions 1A (E1A) and 1B (E1B) of oncogenic adenovirus serotype 12 (Ad12) grow to tumours in syngeneic, immunocompetent rodents. To gain insight into the mechanisms of oncogenic transformation, we point mutated the first splice donor in the Ad12-E1A gene, leading to the loss of the Ad12-E1A9.5S and Ad12-E1A11S/10S proteins and to a conservative amino acid (aa) exchange at position aa 30 (valine vs. leucine) in the Ad12-E1A13S and Ad12-E1A Show more

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