A point of care screen printed potentiometric sensor for therapeutic monitoring of vecuronium

Fahem, Diana K.; Houssini, Ola M. El; El-Rahman, Mohamed K. Abd; Zaazaa, Hala E.

doi:10.1016/j.microc.2019.03.065

Cited by 12 publications

(6 citation statements)

References 39 publications

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“…There are several sensors and detection methods in the research and development phase for TDM, which combine pretreatment methods with detection, developed for on-site monitoring using optical, surface plasmon resonance, , and electrochemical methods. , These methods can achieve clinically relevant detection of various drugs in biological samples with a relatively inexpensive, portable equipment. TDM with surface-enhanced Raman scattering (SERS) has been reported as well .…”

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confidence: 99%

Quantification of Methotrexate in Human Serum Using Surface-Enhanced Raman Scattering—Toward Therapeutic Drug Monitoring

et al. 2021

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Therapeutic drug monitoring (TDM) can improve clinical care when using drugs with pharmacokinetic variability and a narrow therapeutic window. Rapid, reliable and easy to use detection methods are required in order to decrease the time of analysis, and can enable TDM also in resource-limited settings or even at bedside. Monitoring methotrexate (MTX), an anti-cancer drug, is critical, since it is needed to follow the drug clearance rate and decide how to administer the rescue drug, leucovorin (LV), in order to avoid toxicity and even death. We show that with the optimized nanopillar assisted separation (NPAS) method using surface-enhanced Raman scattering (SERS) we were able to measure MTX in PBS and serum in the linear range of 5 to 150 µM and confirmed that MTX detection can be carried out even in the presence of LV. Additionally, when NPAS was combined with centrifugal filtration a quantification limit of 2.1 µM for MTX in human serum sample was achieved. The developed detection method enables fast detection (10 min) and quantification of MTX from human serum (>90% accuracy). Furthermore, we show the potential of the developed method for TDM, when quantifying MTX from clinical samples, collected from patients, who are undergoing high-dose MTX therapy.

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confidence: 99%

Quantification of Methotrexate in Human Serum Using Surface-Enhanced Raman Scattering—Toward Therapeutic Drug Monitoring

et al. 2021

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“…The major advantages of electrochemical sensors are their simplicity, low cost, high sensitivity, multiplexing capability, low detection limits and capability of working with small sample volumes, and miniaturization allowing on-site monitoring [49]. Electrochemical biosensors coupled with C-nanotubes [50], nanoparticles/doped-electrodes [51], and various bioreceptors such as DNA [52], antibodies [53,54], membranes [55], and aptamers [56,57] have recently been used for the detection of anticancer drugs [52], antibiotics [53,54,[56][57][58], and antifungals. Similar to optical sensors, the issue of nonspecific binding still abides in electrochemical sensors due to the inherent nature of bioreceptors and hence needs to be addressed.…”

Section: Trends Trends In In Biotechnology Biotechnologymentioning

confidence: 99%

On-Site Therapeutic Drug Monitoring

Ates

Roberts

Lipman

et al. 2020

Trends in Biotechnology

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Trends in Biotechnology mass spectrometry (LC-MS/MS) (see Glossary) methods. Despite its high specificity, matrix interference may lead to falsely low or high results; that is, the matrix and co-eluting compounds can interfere with the ionization process in MS (via ion suppression/enhancement) [5]. Furthermore, the throughput of LC-MS/MS is lower than that of the conventional immunoassay platforms. Recent studies are either addressing these issues [6,7] or exploiting or improving this method's inherent advantages [8,9]. Accordingly, there has been a significant effort to increase the throughput of chromatographic methods [10]. Pioneering multiplex approaches have been reported for antiretroviral agents (ARVs) [11], antifungals [12], antineoplastics [13], antibiotics [6,7,14], antidepressants [15], and immunosuppressive drugs [16] in the past decade. More recently, ultra-performance liquid chromatography (UPLC)-MS/MS has been used for simultaneous quantification of antibiotics [17] and ARVs from plasma [11] and breast milk samples [18]. Another focus is the extension of TDM studies toward unconventional samples and sampling. Several LC-MS/MS methods have been developed and applied for hair [11,18], dried blood spots [19], urine [20], sweat [21], saliva [22,23], and tissue biopsies [24].

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“…The resulting data would help in stabilizing VEC standard or drug product, resulting in expanded shelf-life or enhanced efficacy. According to ICH guideline Q1A (R2), different stress conditions (hydrolysis, oxidation, photolysis, and thermal degradation) were carried out to test the stability of the drug substance to prove the superiority of stability indicating analytical methods [21,22,24]. VEC was highly degraded when subjected to basic hydrolysis and oxidative degradation TableIV.…”

Section: Forced Degradation Studiesmentioning

confidence: 99%

Stability indicating liquid chromatography method for the analysis of Vecuronium bromide: study of the degradation profile

El-Rahman

Houssini

Fahem

et al. 2020

Heliyon

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A point of care screen printed potentiometric sensor for therapeutic monitoring of vecuronium

Cited by 12 publications

References 39 publications

Quantification of Methotrexate in Human Serum Using Surface-Enhanced Raman Scattering—Toward Therapeutic Drug Monitoring

Quantification of Methotrexate in Human Serum Using Surface-Enhanced Raman Scattering—Toward Therapeutic Drug Monitoring

On-Site Therapeutic Drug Monitoring

Stability indicating liquid chromatography method for the analysis of Vecuronium bromide: study of the degradation profile

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