A poly(γ‐glutamic acid)‐based hydrogel loaded with superoxide dismutase for wound healing

Abstract

The purpose of this study was to develop a poly(γ‐glutamic acid) (γ‐PGA)‐based hydrogel loaded with superoxide dismutase (SOD) to accelerate wound healing. First, γ‐PGA was modified with taurine (γ‐PGAS), and then the SOD‐loaded γ‐PGAS/γ‐PGA hydrogel (SOD‐PGAS/PGA‐H) was prepared by cross‐linking of ethylene glycol diglycidyl ether. The swelling behavior and water vapor transmission rate revealed that PGAS/PGA‐H could create a moist environment for wound surface. In vitro kinetics of SOD release showed that SOD released from PGAS/PGA‐H maintained high activity and SOD‐PGAS/PGA‐H effectively scavenged the superoxide anion. The results of our fibroblast proliferation experiments showed that PGAS/PGA‐H had good cytocompatibility. The effects of SOD‐PGAS/PGA‐H on wound healing were examined in a Type I diabetic rat model with full‐thickness wounds. Twenty‐one days after grafted to wounds, SOD‐PGAS/PGA‐H exhibited a higher rate of wound healing than control group and showed increased collagen deposition and epithelialization. SOD‐PGAS/PGA‐H seems to promote better wound healing and thus might be a promising candidate for wound healing management. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42033.

Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing

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Biomimetic hydrogel loaded with silk and l‐proline for tissue engineering and wound healing applications

“…These radicals must be scavenged to accelerate the rate of wound healing. To protect the tissues from this excessive production of free radicals and oxidative stress, wound dressing materials should be prepared with antioxidant properties . Antioxidant activity is mainly derived from the molecules holding hydroxyl, sulfhydryl, and amino group as functional moieties in its structure .…”

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

“…Simultaneously, superoxide dismutase (SOD) is another antioxidant metalloproteinase existing in organisms, which can catalyze the disproportionation of superoxide radicals (O 2− ) in organisms. It is a natural eliminator of O 2− in organisms and also plays a vital role in the balance of oxidation and antioxidation . After the balance of oxidation and antioxidation broken by excessive ROS, endogenous antioxidants such as SOD and GSH are difficult to resist adverse environment, which eventually results in the decline of cell resistance, metabolic disorders, and secondary injury to wounds, thus aggravating infection and delaying wound healing .…”