A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Gu, Yaming; Guo, Yizhen; Wang, Changyong; Xu, Jiake; Wu, Jianping; Kirk, T.B.; Ma, Dong; Wang, Xue

doi:10.1016/j.msec.2016.09.035

Cited by 103 publications

(50 citation statements)

References 45 publications

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“…As a typical example, PTX, one of the most effective anticancer therapeutics originated from Pacific yew, has been popularly utilized for treatments of liver, ovarian, lung, or breast cancers . The tumor growth inhibition activity of PTX lies on its ability of tubulin β‐subunit binding, which results in the formation of polymerized microtubules and effectively inhibit mitosis at G2 phase before induction of cancer cell death . However, PTX could cause undesired drug resistance mainly in term of drug efflux increase .…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Fan

Cheng

Wang

et al. 2017

Adv Healthcare Materials

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Pump mediated drug efflux is the key reason to result in the failure of chemotherapy. Herein, a novel star polymer β-CD-v-(PEG-β-PNIPAAm) consisting of a β-CD core, grafted with thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(ethylene glycol) (PEG) in the multiple "V"-shaped arms is designed and further fabricated into supramolecular nanocarriers for drug resistant cancer therapy. The star polymer could encapsulate chemotherapeutics between β-cyclodextrin and anti-cancer drug via inclusion complex (IC). Furthermore, the temperature induced chain association of PNIPAAm segments facilitated the IC to form supramolecular nanoparticles at 37 °C, whereas the presence of PEG impart great stability to the self-assemblies. When incubated with MDR-1 membrane pump regulated drug resistant tumor cells, much higher and faster cellular uptake of the supramolecular nanoparticles were detected, and the enhanced intracellular retention of drugs could lead to significant inhibition of cell growth. Further in vivo evaluation showed high therapeutic efficacy in suppressing drug resistant tumor growth without a significant impact on the normal functions of main organs. This work signifies thermo-responsive supramolecular chemotherapy is promising in combating pump mediated drug resistance in both in vitro and in vivo models, which may be encouraging for the advanced drug delivery platform design to overcome drug resistant cancer.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Fan

Cheng

Wang

et al. 2017

Adv Healthcare Materials

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“…The bands located at ~1630 cm −1 and ~1540 cm −1 are assigned to the O=C–NH stretching vibrations from PAMAM structures. Additionally, the presence of the signals from ~2925 cm −1 and ~2850 cm −1 corresponding to –CH 2 – groups from the ethylene core of the dendrimers is confirming that amidoamines groups were covalently grafted to GO-COOH [ 45 ]. The formation of the hybrid GO-PAMAM-BZ monomers was proven through FT-IR investigation for each dendrimer generation employed in the synthesis by comparing the final products with BZ monomers obtained from PAMAM dendrimers as amine source for BZ synthesis.…”

Section: Resultsmentioning

confidence: 92%

Innovative Hyperbranched Polybenzoxazine-Based Graphene Oxide—Poly(amidoamines) Nanomaterials

2020

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The covalent functionalization of graphene oxide (GO) surface with hyperbranched benzoxazine (BZ) structures has been achieved using poly(amidoamine) dendrimers (PAMAM) of different generations. By increasing the PAMAM generation, multiple benzoxazine rings were synthesized decorating the GO layers. The polymerization process and the exfoliation behavior were investigated. The novel BZ-functionalized GO hybrid materials were characterized by a combination of techniques such as FT-IR, XPS, and 1H-NMR for the confirmation of benzoxazine formation onto the GO layer surfaces. Raman and XRD investigation showed that the GO stacking layers are highly disintegrated upon functionalization with hyperbranched benzoxazine monomers, the exfoliation being more probably to occur when lower PAMAM generation (G) is involved for the synthesis of hybrid GO-BZ nanocomposites. The polymerization of BZ rings may occur either between the BZ units from the same dendrimer molecule or between BZ units from different dendrimer molecules, thus influencing the intercalation/exfoliation of GO. DSC data showed that the polymerization temperature strongly depends on the PAMAM generation and a significant decrease of this value occurred for PAMAM of higher generation, the polymerization temperature being reduced with ~10 °C in case of GO-PAMAM(G2)-BZ. Moreover, the nanoindentation measurements showed significant mechanical properties improvement in case of GO-PAMAM(G2)-BZ comparing to GO-PAMAM(G0)-BZ in terms of Young modulus (from 0.536 GPa to 1.418 GPa) and stiffness (from 3617 N/m to 9621 N/m).

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“…In a solid tumor model, shRNA against thymidylate synthase (TS shRNA) complexed with cationic liposome (TS shRNA-lipoplex) was codelivered with oxaliplatin and showed enhanced effects and accumulation of the TS shRNA lipoplex. In breast cancer, a combination treatment using doxorubicin functionalized to graphene oxide (GO-PAMAM) with shRNA against MMPS showed an enhanced therapeutic response (Gu et al, 2017). Zhang et al used a combined approach to deliver Akt-shRNA with drug demethylcantharate.…”

Section: Nanoparticle-based Codelivery Of Drugs and Genesmentioning

confidence: 99%

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Amreddy

Babu

Muralidharan

et al. 2018

Advances in Cancer Research

234

145

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Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.

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A polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery

Cited by 103 publications

References 45 publications

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Thermoresponsive Supramolecular Chemotherapy by “V”‐Shaped Armed β‐Cyclodextrin Star Polymer to Overcome Drug Resistance

Innovative Hyperbranched Polybenzoxazine-Based Graphene Oxide—Poly(amidoamines) Nanomaterials

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

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