A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

Jackson, J. Leah; Wang, Min; Tf, Cruz; Cindric, Steven; Arsenault, Larry; Hoff, D. Von; Degan, D; Hunter, William L.; Burt, Helen M.

doi:10.1038/bjc.1997.174

Cited by 35 publications

(18 citation statements)

References 20 publications

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“…The inclusion of PEG in PCL beads has been shown to allow for concentration-dependent increases in the release rate of water-soluble drugs from such polymers [18]. In this study, drug-loaded bone cement films or beads that included PEG were observed to fragment easily under low manual pressure especially at concentrations of PEG greater than 10%.…”

Section: Resultsmentioning

confidence: 79%

The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

Jackson

Leung

Duncan

et al. 2011

Drug Deliv. and Transl. Res.

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Bone cement containing antibiotics is commonly used to treat orthopedic related infections. However, effective treatment (especially of resistant bacteria, methacillin-resistant Staphylococcus aureus (MRSA)) is compromised by very low levels of drug release so that typically less than 10% of loaded drug is released over a 6-week period. The objective of this study was to investigate the effect of incorporation of water soluble excipients (polyethylene glycol, sodium chloride, or dextran) into antibiotic-loaded cement on mechanical strength and drug release properties. Poly(methyl methylacrylate) cement implants containing various amounts of drug (vancomycin, linezolid or fusidic acid (all MRSA active)) and excipients were cast in the form of beads or films and characterized using differential scanning calorimetry. Mechanical strength as assessed by Young's modulus was determined by thermo-mechanical analysis. Drug release was measured by incubation in phosphate buffered saline with analysis by HPLC methods. The inclusion of sodium chloride up to 20% w/w caused only minor reductions in Young's modulus. Vancomycin and linezolid released very slowly from unmodified bone cement beads (less than 3% released by 4 weeks) whereas fusidic acid released more quickly (approximately 8% released by 4 weeks). The inclusion of sodium chloride or dextran in bone cement resulted in major increases in the release rate of vancomycin, linezolid and fusidic acid. These studies support the inclusion of sodium chloride and dextran in bone cement to increase the release rate of vancomycin, linezolid, or fusidic acid without compromising the mechanical strength of the composite material.

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Section: Resultsmentioning

confidence: 79%

The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

Jackson

Leung

Duncan

et al. 2011

Drug Deliv. and Transl. Res.

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“…In addition, our pervious in vivo studies indicated that KynA is more potent than Kyn in suppressing the expression of fibronectin, which is essential for collagen deposition and assembly . Most importantly, the use of KynA would be safer even if it diffuses out into circulation because, (1) it is an end product in the Kyn pathway; therefore, there is no chance that it get metabolized to another product with unknown effect, and (2) its diffusibility through the blood brain barrier is very poor, which limits its accessibility to the central nervous system . Finally, KynA is far less water soluble than Kyn and easily dissolvable in organic solvents, such as DMF, which enable the use of organic‐based electrospinning process.…”

Section: Resultsmentioning

confidence: 99%

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Poormasjedi‐Meibod

Pakyari

Jackson

et al. 2016

J Biomedical Materials Res

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Dermal fibrosis, characterized by excessive extracellular matrix (ECM), is a pathological condition with limited effective therapeutic modalities. Lack of an antiscarring dressing further impedes the preventive measures for this condition. Here, we develop a new antiscarring dressing and investigate its potential as a slow-releasing vehicle for kynurenic acid (KynA), an antifibrotic agent. KynA was incorporated into polymethyl methacrylate (PMMA) nanofibers, containing increasing concentration of polyethylene glycol (PEG). Fibre morphology, water absorption capacity, surface hydrophilicity, in vitro drug release profile, and in vivo antifibrotic effects were investigated. Increasing concentrations of PEG (1-20%) significantly increased surface hydrophilicity, water absorption capacity, and drug release. Based on the obtained release profiles, PMMA + 10% PEG was the preferred formulation for sustained KynA release up to 120 hours. In vitro studies confirmed the preservation of KynA antifibrotic properties during electrospinning, indicated by fibroblasts proliferation suppression and ECM expression modulation. In vivo application of KynA-incorporated films significantly inhibited collagen (23.89 ± 4.79 vs. 6.99 ± 0.41, collagen-I/β-actin mRNA expression, control vs. treated) and fibronectin expression (7.18 ± 1.09 vs. 2.31 ± 0.05, fibronectin/β-actin mRNA expression, control vs. treated) and enhanced the production of an ECM-degrading enzyme (2.03 ± 0.88 vs. 11.88 ± 1.16 MMP-1/β-actin mRNA expression, control vs. treated). The fabricated KynA-incorporated films can be exploited as antifibrotic wound dressings. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2334-2344, 2016.

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“…15,16 A polymer vanadium-based drug confirmed its potential as antineoplastic agent. 17 Liposoural surface-loading of water-soluble cationic iron(III) porphyrines allowed for a targeted necrosis of tumor cell. 18 Cobalt complexes exhibited selective effects on tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel poly 2‐vinylpyridine‐mixed metal complexes and studying their effect as antitumor chemotherapeutic agents, part 2

Mazrouaa

Badawi

Noaman

et al. 2010

J of Applied Polymer Sci

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The poly2-vinylpyridine and cationic polymer-mixed metal complexes (P2VPMC) have been prepared and characterized by analytical measurement such as: molecular weight, elemental analysis, IR-spectroscopy, NMR-spectroscopy, XRD, and UV. The degree of N-alkylation of poly vinyl pyridine (P-2VP) was 10% determined by chlorine content according to elemental microanalysis. Through ICP instrument the complexation between P-2VPC and the mixed metal chlorides was proven. The structure of the samples was characterized using X-ray diffraction. It was found that the complexes have amorphous properties. The antitumor activity of this compound was examined in vitro on cell lines. The results reflect pronounced cytotoxicity of P-2VPMC against animal experimental EAC cells line, and human, HeLa, HCT116 and Hep-G2, cell lines. Antitumor activity of the novel compound as applied on mice bearing Ehrlich solid carcinoma, revealed delays tumor growth compared with untreated animals and decreases tumor volume. The antitumor activity of the P2VPMC might be due to its ability to pass through the membrane and interact with, DNA causing cross-linking action which might be the key factor for great antitumor activity of the P2VPMC compound.

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A polymer-based drug delivery system for the antineoplastic agent bis(maltolato)oxovanadium in mice

Cited by 35 publications

References 20 publications

The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

Development of a nanofibrous wound dressing with an antifibrogenic properties in vitro and in vivo model

Synthesis of novel poly 2‐vinylpyridine‐mixed metal complexes and studying their effect as antitumor chemotherapeutic agents, part 2

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