A polymer nanoplatform with high transfection rate for the efficient gene therapy of peripheral arterial diseases

Guo, Xin; Liu, Junchao; Zhang, Rong; Jin, Yi; Wang, Xin; Li, Bo; Peng, Zhiyou; Zhang, Xing; Shen, Jiefeng; Lu, Xinwu; Liu, Xiaobing; Liu, Guang

doi:10.1016/j.jddst.2023.104645

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.104645

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A polymer nanoplatform with high transfection rate for the efficient gene therapy of peripheral arterial diseases

Xin Guo,

Junchao Liu,

Rong Zhang

et al.

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2024

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Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease

Huang,

Stern,

Oropeza

et al. 2024

ATVB

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Peripheral artery disease is an atherosclerotic disease associated with limb ischemia that necessitates limb amputation in severe cases. Cell therapies comprised of adult mononuclear or stromal cells have been clinically tested and show moderate benefits. Bioengineering strategies can be applied to modify cell behavior and function in a controllable fashion. Using mechanically tunable or spatially controllable biomaterials, we highlight examples in which biomaterials can increase the survival and function of the transplanted cells to improve their revascularization efficacy in preclinical models. Biomaterials can be used in conjunction with soluble factors or genetic approaches to further modulate the behavior of transplanted cells and the locally implanted tissue environment in vivo. We critically assess the advances in bioengineering strategies such as 3-dimensional bioprinting and immunomodulatory biomaterials that can be applied to the treatment of peripheral artery disease and then discuss the current challenges and future directions in the implementation of bioengineering strategies.

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Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease

Huang,

Stern,

Oropeza

et al. 2024

ATVB

View full text Add to dashboard Cite

show abstract

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A polymer nanoplatform with high transfection rate for the efficient gene therapy of peripheral arterial diseases

Cited by 1 publication

References 35 publications

Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease

Bioengineering Cell Therapy for Treatment of Peripheral Artery Disease

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