2020
DOI: 10.21203/rs.3.rs-80098/v1
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A Polymeric Diet Rich in Transforming Growth Factor Beta 2 Does Not Reduce Inflammation in Chronic 2,4,6-trinitrobenzene Sulfonic Acid Colitis in Pre-pubertal Rats

Abstract: Background: Pediatric Crohn’s disease is characterized by a higher incidence of complicated phenotypes. Murine models help to better understand the dynamic process of intestinal fibrosis and test therapeutic interventions. Pre-pubertal models are lacking. We aimed to adapt a model of chronic colitis to pre-pubertal rats and test if a polymeric diet rich in TGF-β2 could reduce TNBS-induced intestinal inflammation and fibrosis. Methods: Colitis was induced in 20 five-week-old Sprague-Dawley male rats by weekly r… Show more

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“…Very few studies have also investigated more complex nutrients compared to unique nutrients in preclinical models of intestinal fibrosis. We have evaluated the effects of a polymeric diet enriched in TGF-β2 in a model of pre-pubertal rats with chronic TNBS-induced colitis and we failed to reverse the inflammation or intestinal fibrosis in our tested conditions [ 98 ]. Very recently, a study investigated the effects of fermented rice bran on post-colitis restoration demonstrating a reduction of ECM-associated markers and TGF-β/Smad signaling [ 99 ].…”
Section: Beneficial Effects Of Dietary Componentsmentioning
confidence: 99%
“…Very few studies have also investigated more complex nutrients compared to unique nutrients in preclinical models of intestinal fibrosis. We have evaluated the effects of a polymeric diet enriched in TGF-β2 in a model of pre-pubertal rats with chronic TNBS-induced colitis and we failed to reverse the inflammation or intestinal fibrosis in our tested conditions [ 98 ]. Very recently, a study investigated the effects of fermented rice bran on post-colitis restoration demonstrating a reduction of ECM-associated markers and TGF-β/Smad signaling [ 99 ].…”
Section: Beneficial Effects Of Dietary Componentsmentioning
confidence: 99%