A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer

Ding, Cuimin; Li, Ruijuan; Peng, Jingcui; Li, Shengmian; Guo, Zhanjun

doi:10.3892/etm.2012.469

Cited by 34 publications

(38 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CC genotype was associated with longer survival time and a decreased risk of death in NSCLC patients (Xu et al, 2013a). Similarly, the CC+CT genotype was closely associated with longer survival of SCLC patients (Ding et al, 2012). SNP rs2239680 in the miR-335 binding site of the oncogene BIRC5 may alter the susceptibility to lung cancer.…”

Section: Discussionmentioning

confidence: 93%

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we examined whether a single-nucleotide polymorphism in the promoter region of the let-7 family (rs10877887) is associated with the susceptibility to L.Q. Shen et al. 4506©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4505-4512 (2015) and prognosis of lung adenocarcinoma cancer. A hospital-based casecontrol research model was used in our study. The single-nucleotide polymorphism was genotyped in 69 lung cancer patients and 75 healthy controls by direct sequencing. The correlation between rs10877887 genotypes and the susceptibility to lung cancer was evaluated using an unconditional logistic regression model. Populations with the CT+CC genotype had a significantly increased AC risk compared to those with the TT genotype (CT+CC vs TT: P = 0.043, OR = 2.032, 95%CI = 1.018-4.054). Furthermore, the risk effect was greater in subgroups of females over 60 years old (CT+CC vs TT: OR = 6.857, 95%CI = 1.425-33.008, P = 0.012), and the C allele were confirmed to be a risk factor related to lung cancer in these females (P = 0.012). The singlenucleotide polymorphism rs10877887 in the promoter region of the let-7 family was found to be responsible for the susceptibility to lung adenocarcinoma cancer in Chinese individuals. This association was significantly stronger in females who were more than 60 years old.

show abstract

Section: Discussionmentioning

confidence: 93%

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Additionally, the RNA-induced silencing complex (RISC) including GEMIN3 and GEMIN4 selects a single strand as the mature miRNA and guides the mature miRNAs to their target mRNA sites (10,13-16). miRNA-related single nucleotide polymorphisms (miR-SNPs), defined as SNPs in miRNA genes, miRNA binding site and miRNA processing machinery, are able to modulate miRNA and target gene expressions in order to influence cancer risk, treatment efficacy and patient prognosis (9,(17)(18)(19)(20).A miR-SNP of rs11077 located in the 3'UTR of the miRNA processing gene XPO5 has shown its association with the chemotherapeutic response in metastatic colon cancer as well as recurrence in resected non-small cell lung cancer (NSCLC) (9,19). In the present study, we evaluated the predictive power of this SNP on the overall survival of SCLC patients.…”

mentioning

confidence: 99%

A microRNA-related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients

Guo

Wang

et al. 2013

Biomedical Reports

Self Cite

View full text Add to dashboard Cite

Abstract. MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes affect cancer risk, treatment efficacy and patient prognosis. A miR-SNP of rs11077 located in the 3'UTR of miRNA processing machinery gene XPO5 was examined in small cell lung cancer (SCLC) patients to evaluate its association with cancer survival. A total of 42 patients were enrolled in the present study and genotyped for rs11077 and survival was assessed using the Kaplan-Meier method, as well as univariate and multivariate analyses. The AA genotype of rs11077 was identified for its significant association with better survival time (P=0.023). In addition, rs11077 was found to associate independently with overall survival in SCLC patients by multivariate analysis (relative risk 2.469; 95% CI, 1.088-5.603; P=0.031). The findings of this study suggest that although miR-SNP studies for miRNA processing machinery genes are still at an early age, miR-SNPs have an impact on cancer survival. In conclusion, a miR-SNP in the 3'UTR region of the XPO5 gene was identified as an independent prognostic marker for survival of advanced SCLC patients. IntroductionSmall cell lung cancer (SCLC), commonly classified by the Veterans Administration Lung Cancer Study Group as Limited stage and Extensive stage groups, constitutes ~15% of all lung cancer cases and is strongly associated with cigarette smoking (1-3). The prognosis of SCLC, which has been associated with extent of disease and other factors, is poor, whereas the life expectancy of those with untreated SCLC is ~3.5 months for the limited stage group and 6 weeks for the extensive stage group (4-6). Although genetic factors have been identified as prognostic factors for SCLC, the underlying mechanism of this cancer remains unknown (7-9).MicroRNAs (miRNAs) are RNA molecules that are ~22 nucleotides long and are involved in various biological processes, such as embryonic development, cell differentiation, proliferation, apoptosis, cancer development and insulin secretion (10,11). More than 700 miRNAs have been identified in humans and these miRNAs are responsible for regulating at least 30% of protein-coding gene expressions (12). A growing body of evidence suggests that miRNAs play important roles in a broad range of biological processes, as previously mentioned (9-11). In the miRNA processing, long primary transcripts of miRNAs (pri-miRNAs) are processed in the nucleus by RNase III Drosha and transported to the cytoplasm by the nuclear transport factor exportin-5 (XPO5) and RAN. In the cytoplasm, RNase III Dicer and transactivation-responsive RNA-binding protein (TRBP) mediate the processing of pre-miRNAs in order to release a 21-bp dsRNA. Additionally, the RNA-induced silencing complex (RISC) including GEMIN3 and GEMIN4 selects a single strand as the mature miRNA and guides the mature miRNAs to their target mRNA sites (10,13-16). miRNA-related single nucleotide polymorphisms (miR-SNPs), defined as SNPs in miRNA genes, miRNA binding site and miRNA processing machi...

show abstract

“…SET8 has been shown to be correlated with a series of human tumors, such as hepatocellular cancer, breast cancer, ovarian cancer, and lung cancer (Song et al, 2009;Ding et al, 2012;Guo et al, 2012;Wang et al, 2012;Xu et al, 2013). However, no studies have demonstrated a correlation between SET8 and gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

SET8 expression is associated with overall survival in gastric cancer

Xl¹,

Zj²,

Xl³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. SET8, a member of the SET domain-containing methyltransferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method to determine the predictive value of SET8 expression levels for gastric cancer outcome. The relationship between SET8 expression and the 5-year survival rate of gastric cancer patients was assessed. High expression of SET8 was associated with a shorter survival time in gastric cancer patients, and the level of SET8 expression was found to be an independent predictor of gastric cancer outcome (relative risk = 1.939; 95% confidence interval = 1.025-3.668; P = 0.042). Analysis of SET8 levels may help in the identification of patient subgroups that are at high risk for poor disease outcomes.

show abstract

A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer

Cited by 34 publications

References 25 publications

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

A microRNA-related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients

SET8 expression is associated with overall survival in gastric cancer

Contact Info

Product

Resources

About