A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth

Macones, George A.; Parry, Samuel; Elkousy, Mohammed; Clothier, Bonnie; Ural, Serdar H.; Strauss, Jerome F.

doi:10.1016/j.ajog.2004.01.001

Cited by 272 publications

(159 citation statements)

References 19 publications

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“…Bacterial vaginosis (BV) has been prospectively linked to various adverse reproductive and pregnancy-related events including endometritis, pelvic inflammatory disease, preterm labor and preterm delivery, and postpartum endometritis (1)(2)(3)(4)(5)(6)(7)(8). BV is a polymicrobial superficial vaginal condition characterized by a reduced number of hydrogen-peroxide producing (H 2 O 2 ) Lactobacillus spp.…”

Section: Introductionmentioning

confidence: 99%

First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women

Nelson

Bellamy

Nachamkin

et al. 2007

Fertility and Sterility

111

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Objective-To examine the role of first trimester bacterial vaginosis (BV) and level of BVassociated microorganisms diagnosed using the Nugent's Gram stain criteria and the risk of second trimester pregnancy loss among urban women. Design-Prospective cohort study.Setting-Pregnant women seeking prenatal care in the first trimester.Patients-Women presenting for their first prenatal care visit who had completed 12 weeks gestation or less and resided within Philadelphia PA. Main Outcome Measures-Pregnancy Loss.Results-1948 women enrolled at a mean gestational age of 10 weeks (range 7.4 to 12.6 weeks). Women with the highest level of BV-related vaginal flora alteration compared to women with normal vaginal flora had over a twofold increased risk of second trimester pregnancy loss after adjustment for confounders (adjusted HR: 2.49, 95% CI: 1.13 to 5.48). Low Lactobacillus spp, and the absence of Lactobacillus spp. were also significantly related to the risk of second trimester pregnancy loss (aHR: 1.32, 95% CI: 1.10-1.64 and aHR: 2.30, 95% CI: 1.09 -4.85; respectively). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-Overall BV positivity was not related to second trimester pregnancy loss. NIH Public AccessComparing the highest to lowest tertile of BV positivity in early pregnancy conferred a two-fold increased risk of second trimester pregnancy loss and low amounts or the absence of Lactobacillus spp. in the first trimester also significantly increased the risk of second trimester pregnancy loss.

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Section: Introductionmentioning

confidence: 99%

First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women

Nelson

Bellamy

Nachamkin

et al. 2007

Fertility and Sterility

111

View full text Add to dashboard Cite

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“…6 The possible genetic context between infection, inflammation and pre-term delivery is also supported by other findings, in particular for the IL4 and TNF-␣ genes. [7][8][9] The human mannosebinding lectin (MBL) is an important component of the body's first line immune response. MBL deficiency has been repeatedly associated with an increased susceptibility for a wide variety of infections.…”

mentioning

confidence: 99%

Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Bodamer

Mitterer

Mäurer

et al. 2006

Genetics in Medicine

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Purpose: Human mannose-binding lectin, encoded by the MBL2 gene, is an important component of innate immunity and an important regulator of inflammatory processes. MBL2 gene polymorphisms are associated with an increased risk of neonatal infections and some data suggest a relation between the maternal MBL2 genotype and the risk of premature delivery. In this study, we evaluated whether there is an association between the fetal MBL2 genotype and prematurity. Methods: A microarray-based on-chip PCR method was used to simultaneously detect five common MBL2 polymorphisms (codon 52, 54, 57; promoter -550, -221) in 204 DNA samples isolated from archival blood cards. MBL2 genotypes of infants born before the 36 th week of pregnancy (N ϭ 102) were compared to a control group of infants born at term after the 37 th week (N ϭ 102). Results: The frequency of the codon 52 polymorphism was significantly higher in the pre-term group compared to the term group (10.8% versus 4.9%, P ϭ 0.04), while the frequency of the codon 54 polymorphism was equal in both groups (11.3% versus 11.8%). Interestingly, carriers of genotypes (O/O) likely conferring deficient MBL plasma levels were more common in the group of premature birth (9.8% versus 2.9%, P ϭ 0.05), while the promoter -550 C/C genotype was underrepresented in the pre-term birth group (24.5% versus 39.2%, P ϭ 0.03). Conclusion: Our data add to the knowledge about genetic predisposition to prematurity and suggest that the fetal MBL2 genotype might be an additional genetic factor contributing to the risk of premature delivery. Genet Med 2006:8(8):518-524.

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“…73 Maternal fiziksel aktivitenin uterin kan akımında azalma ve stres hormonlarının (örneğin; kortikotropin "releasing" hormon) kan düzeylerinde artış yaparak riski artırdığı iddia edilmişse de maternal aktivite ve preterm doğum arasındaki ilişki tam olarak belirlenememiştir. 74,75 Öte yandan, uzun süre ayakta durma ile preterm doğum arasında artmış risk saptanmıştır.…”

Section: -72unclassified

Prediction and Diagnosis of Preterm Delivery: Review

Çetinkaya¹,

Biberoğlu²,

Kırbaş³

et al. 2017

Turkiye Klinikleri J Gynecol Obst

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A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth

Cited by 272 publications

References 19 publications

First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women

First trimester bacterial vaginosis, individual microorganism levels, and risk of second trimester pregnancy loss among urban women

Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth

Prediction and Diagnosis of Preterm Delivery: Review

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