A Polymorphism in the Promoter Region of the Selenoprotein S Gene (SEPS1) Contributes to Hashimoto's Thyroiditis Susceptibility

Abstract

Our findings support the existence of a link between SEPS1 promoter genetic variation and HT risk.

A case–control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population

“…The major allele C and genotype CC in SELENOS rs7178239 showed different trend in GD and HT patients when compared to the control. While the major allele C and CC genotype in rs28665122 of SELENOS increased in both GD and HT patients than the control, different to the result for another study, in which these allele and genotype decreased significantly in their HT patients [14]. Our association analysis showed negative and the distribution difference showed nonsignificant.…”

“…Our results were conflicted to the result from the Portuguese population study. In that study, the higher allele A in SELENOS rs28665122 had been found to be associated with the HT risk [14]. Different selenium nutrition state in different populations may contribute to conflicting results, the contribution of genetic variants in AITD mechanism may be another reason.…”

“…No significant differences were observed in the genotypic distribution of the SELENOS polymorphisms analyzed in Spanish cohorts between patients suffering from autoimmune diseases with a clear inflammatory component, like T1D, RA or IBD and controls [34]. While the SELENOS rs28665122 polymorphism had been found to be associated with the risk of spontaneous preterm birth in a Chinese population [35], the existence of association between this genetic variation and HT risk was also found in a Portuguese population with a higher allele A proportion in the patient group [14]. Here we detected the link between rs28665122 and rs7178239 polymorphisms in SELENOS gene and AITD in a Chinese population.…”

A 2016 Italian Survey about the Clinical Use of Selenium in Thyroid Disease

“…There are still urgent research questions concerning the importance of baseline Se status for successful supplementation and about potential genetic/sex-specific differences in Se metabolism [31] . Ongoing studies will clarify how endocrinologists can appropriately determine Se treatment for thyroid disease management [16,32] .…”

Hypothyroidism-Associated Autoimmune Thyroiditis and Papillary Thyroid Cancer

“…Recently, the family of selenoproteins has been described in correlation with these two maladies since selenium has one of the highest concentrations in thyroid and the enzymes using it as co-factor are involved in oxidative status, thyroid hormone synthesis, immune modulation and mutagenesis [20][21][22][23].…”