A polyol-stevia blended sugar replacer exhibits low glycemic response among human subjects

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

“…Among these studies, a minority exhibited these effects (especially gastrointestinal side effects), which generally occurred mildly and in few study participants. These side effects can be justified due to low xylitol absorption in the gastrointestinal tract, which consequently results in increased bowel movement, nausea, flatulence, bloating, stomachache, diarrhea, and vomiting [13,41,[92][93][94][95][96]. One study reported more complicated side effects (deep vein thrombosis, bronchospasm, and hemoptysis); however, the participants of this study presented a critical health condition Pesqui.…”

“…Preventive treatment prevailed among studies and was performed to evaluate especially antimicrobial action [22][23][24][25][26][27][28][29][30], dental biofilm control [23,25,28,31] and blood glucose levels [9,13,14,32], while the therapeutic treatment was tested mainly for xerostomia [33][34][35][36], halitosis [35,[37][38][39], gastric emptying [7,8,40,41], and respiratory tract infections [11,42]. The studies cited above showed a positive effect, which suggests that xylitol can be used for such outcomes if it follows the other characteristics of the studies' interventions.…”

“…Xylitol has also been used to regulate blood glucose levels, as this sucrose substitute has a low absorption rate in the gastrointestinal tract [1,13,32,75]. For the same reason, xylitol can be used for gastric emptying [7,12,40,68,91].…”

“…The xylitol can also be used in medicine to treat, for example, acute otitis media (AOM) because of its antibacterial properties against Streptococcus pneumoniae [10,11] and to facilitate gastric emptying after surgical procedures [7,12]. In nutrition, solutions with xylitol can be used to control blood glucose levels [13,14], and malnutrition in postoperative patients [15,16].…”

“…Due to its obtention and purification processes, the use of xylitol products is relatively expensive as a sweetener compared to sucrose. In addition, because it is poorly hydrolyzed and absorbed by the small intestine, it can cause osmotic diarrhea to flatulence when consumed in high amounts [10,13,17,18].…”