A polyphenol rich sugarcane extract as a modulator for inflammation and neurological disorders

Ji, Jin; Flavel, Matthew; Xin, Yang; Chen, Oliver C.Y.; Downey, Luke A.; Stough, Con; Kitchen, Barry J.

doi:10.1016/j.phanu.2020.100187

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…According to several studies, tricin is suitable for clinical development due to its excellent pharmacological efficacy, bioactive properties, and low toxicity [ 38 ]. Tricin is considered a promising nutraceutical due to the properties that it exhibits, such as anticancer [ 39 , 40 ], antiobesity [ 41 ], antidiabetic [ 42 ], antioxidant [ 43 , 44 ], anti-inflammatory [ 45 , 46 ], and antiviral [ 47 ] activities.…”

Section: Resultsmentioning

confidence: 99%

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Oliveira¹,

Carvalho²,

Oliveira³

et al. 2022

Foods

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The sugarcane processing industry generates a large amount of straw, which has a negative environmental impact, and high costs are associated with their elimination, wasting their potential bioactive value attributed to their richness in polyphenols. In this study, an ethanolic extract produced from sugarcane straw was screened for its phenolic compounds content, and the potential use of this extract in the development of a food ingredient was further evaluated. Fifty different secondary metabolites belonging to the hydroxybenzoic acids, hydroxycinnamic acids, and flavonoids were identified by liquid chromatography–electrospray ionization–ultrahigh-resolution—quadrupole time of flight–mass spectrometry (LC-ESI-UHR-QqTOF-MS). The predominant phenolic compounds found were 4-hydroxybenzaldehyde, chlorogenic acid, and 5-O-feruloylquinic acid. The obtained extracts showed strong potential as food preservatives by exhibiting (a) antioxidant activity using both 2.2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt radical cation (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods; and (b) antimicrobial capacity, with a minimum inhibitory concentration of 50 mg/mL for Staphylococcus aureus, 74% inhibition for Bacillus cereus, and 44% for Salmonella enterica; and (c) the capacity to inhibit a food browning enzyme, tyrosinase (28–73% for 1–8 mg/ mL). Moreover, the extracts showed antidiabetic potential by inhibiting the enzymes α-glucosidase (15–38% for 1.25–5.00 mg/mL) and dipeptidyl peptidase-IV (DPP-IV) (62–114% for 0.31–5.00 mg/mL). The extract (0.625 mg/mL) also exhibited the capacity to reduce proinflammatory mediators (i.e., interleukins 6 and 8, and tumor necrosis factor alpha) when Caco-2 cells were stimulated with interleukin 1 beta. Thus, sugarcane straw extract, which is rich in phenolic compounds, showed high potential to be used in the development of food-preservative ingredients owing to its antioxidant and antimicrobial potential, and to be explored as a food supplement in diabetes prevention and as coadjuvant to reduce intestinal inflammation by reducing proinflammatory mediators.

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Section: Resultsmentioning

confidence: 99%

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Oliveira¹,

Carvalho²,

Oliveira³

et al. 2022

Foods

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“…We recently reported that a polyphenol rich sugarcane extract (PRSE) obtained from sugarcane molasses using a patented extraction process contains a high level of phenolic compounds including tricin, apigenin, and luteolin, and displays a full spectrum of antioxidant property that effectively neutralizes six different species of ROS [6]. In another study, we also examined the anti-inflammatory effect of Officinol™ via its inhibitive effect on pro-inflammatory cytokine tumor necrosis factor (TNF-α) and activation effect on nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor deployed by a cellular system to counter oxidative stress and inflammation [7].…”

Section: Introductionmentioning

confidence: 99%

Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Jin

Xin²,

Flavel³

et al. 2020

Cosmetics

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Increasing evidence suggests that environmental stress, such as UV radiation, generates reactive oxygen and nitrogen species in skin cells, leading to histochemical changes including skin disorders and aging, hyper pigmentation, and increased formation of wrinkles. Besides the defensive system in skin composed of vitamins and intrinsic antioxidant enzymes, topical and skin conditioning products have been used commonly to eradicate or eliminate these skin ailments. Among various ingredients providing nourishing and moisturizing effect in skin, antioxidants have been reported to be a key ingredient to counteract skin aging processes and skin disorders. Derived from a patented extraction process, a polyphenol rich sugarcane concentrate (Officinol™) becomes the focus of this study due to its rich content of polyphenols known to be strong antioxidants. In this work, we carried out a series of cell-based in vitro studies to examine the use of Officinol™ in anti-aging and skin care functions. Our studies show that Officinol™ activated telomerase, a major biomarker that have been reported to be associated with slowed cellular aging process. When skin cells were under environmental stress such as UV radiation, Officinol™ inhibited MMP-1, an interstitial collagenase in skin cells, and deterred the breakdown of collagen that provides supple texture in skin. Officinol™ also inhibited cellular expression of melanin pigmentation and tyrosinase activity, two major biomarkers causing skin pigmentation and aging spots, and inhibited elastase, an enzyme that facilities the reduction of skin elasticity. At the end of the investigation, we carried out a 10-person, pilot study to examine the effect of Officinol™ on skin lightening and fine line and wrinkle reduction in human skin. The combination of the in vitro and the human pre-study indicates that Officinol™ could provide significant preventative and protective functions including antioxidant, anti-aging, wrinkle reduction, and skin brightening for human skin suffering from aging and other stress. These findings are to be confirmed with a larger scale clinical study at a later stage.

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“…10010023, Gibco, New York, NY, USA) before treatment. The chemical composition of PRSE has been described previously [26] and is prepared by the processing of sugarcane with ethanol extraction of the hydrophobic polyphenols, as described here [44]. Briefly, the PRSE used in this study is made using a patented proprietary process from the juice of the sugarcane plant Saccharum officinarum.…”

Section: Methodsmentioning

confidence: 99%

“…It is also able to impart benefits in diabetes, has anti-bacterial effects and improves the cosmetic effects of aging in the skin [25]. PRSE has also been shown to modulate the immune system, with effects on inflammation, cancer and neurological disorders [26,27].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

et al. 2021

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As inflammatory lifestyle factors become more prevalent and as the population ages, the management of inflammation will become increasingly relevant. Plant polyphenols are powerful antioxidants that are known to have beneficial effects in a number of diseases with an inflammatory or oxidative component, such as malignancy, cardiovascular disease and arthritis. Polyphenol-rich sugarcane extract (PRSE) is a novel preparation with high concentrations of polyphenolic antioxidants, with some evidence to show benefits in health, but there is limited research investigating its effects on immunomodulation. This study determined the effects of PRSE on human monocyte cells in vitro. We show that PRSE has an immunomodulatory effect in U937 human monocyte cells, altering the expression of cellular surface markers, with an increased expression of CD16 and CD11b, as well as small changes in CD40, CD80, CD80, CD206 and MHCI. It also modulates the profile of secreted cytokines, increasing IL-1β, TNFα, IL-6, IL-8, IL-4 and IL-10. These changes are consistent with the advanced differentiation of the monocyte, as well as the switch from the M1 to M2 phenotype in macrophages. We also demonstrate that this effect is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect. PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing. Future studies should identify specific mechanisms underlying the changes and evaluate their effectiveness in animal models of disease.

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A polyphenol rich sugarcane extract as a modulator for inflammation and neurological disorders

Cited by 14 publications

References 28 publications

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Sugarcane Straw Polyphenols as Potential Food and Nutraceutical Ingredient

Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

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