A polysaccharide found in Paulownia fortunei flowers can enhance cellular and humoral immunity in chickens

Wang, Qiuju; Meng, Xiuyan; Zhu, Lin; Xu, Yan; Cui, Wenping; He, Xiaoyun; Wei, Kai; Zhu, Rui‐Liang

doi:10.1016/j.ijbiomac.2019.01.168

Cited by 34 publications

(21 citation statements)

References 35 publications

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“…Yang et al [26] have reported that extracts from Astragalus membranaceus and Scutellaria baicalensis can increase type 1 helper T (Th1)-type cellular immune response in UV-attenuated Toxoplasma gondii -infected mice model. Wang et al [27] have showed that the polysaccharide from Paulownia fortunei flowers can promote cellular and humoral immunity in chickens vaccinated with ND vaccine through increasing the levels of IL-2 and IFN-γ, duodenal sIgA content as well. Additionally, Zhao et al [28] have reported that polysaccharides from the rhizome of Atractylodis macrocephalae Koidz (RAMPS) could be an immunopotentiator in chickens vaccinated with ND vaccine, which enhances serum HI antibody titer and improves the percentages of CD4 + and CD8 + T cells.…”

Section: Discussionmentioning

confidence: 99%

The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken

Yang

Zhang

Xu³

et al. 2019

Bioscience Reports

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The extracts of Paulownia tomentosa (P. tomentosa) exhibit multiple pharmacological activities. In the present study, P. tomentosa flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated in chickens. The results showed that in a certain range of concentrations, PTFP treatment can dose-dependently enhance lymphocyte proliferation. Then, 280 14-days-old chickens were randomly divided into seven groups, and vaccinated with ND vaccine except blank control (BC) group. At the first vaccination, chickens were orally administrated with PTFP at concentration ranging from 0 to 50 mg/kg once a day for 3 successive days, and the BC group was treated with physiological saline. The lymphocyte proliferation rate, serum antibody titer, and levels of interferon-γ (IFN-γ) were respectively measured on 7, 14, 21, and 28 days after the first vaccination. The results showed that PTFP at the suitable doses could significantly promote lymphocyte proliferation, enhance serum antibody titer, and improve serum IFN-γ concentrations. Taken together, these data indicated that PTFP could improve the immune efficacy against ND vaccine in chickens, and could be as the candidate of a new-type immune adjuvant.

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Section: Discussionmentioning

confidence: 99%

The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken

Yang

Zhang

Xu³

et al. 2019

Bioscience Reports

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“…Various polysaccharides, such as Astragalus polysaccharide, Lentinan, Angelica sinensis polysaccharide, and Lycium barbarum polysaccharide, have been proved to possess potent immunomodulatory activity (Su et al, 2014;Wang et al, 2016;Sun et al, 2018;Chen et al, 2020;Ren et al, 2021). The Paulownia tomentosa (P. tomentosa), as Chinese herbal medicine, has been widely used to treat stomach disorders, diarrhea, gonorrhea, erysipelas, hypertension, enteritis, tonsillitis, bronchitis, and dysentery (Dai et al, 2015;Liu et al, 2017;Lee et al, 2018;Wang et al, 2019). Recent researches have proved that P. tomentosa possesses various pharmacological activities, such as antibacterial, anti-inflammatory, antiphlogistic, antitussive, antiasthmatic, immunomodulatory, antioxidant, antiviral, and anticholinesterase activities (Dai et al, 2015;Liu et al, 2017;Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The Paulownia tomentosa (P. tomentosa), as Chinese herbal medicine, has been widely used to treat stomach disorders, diarrhea, gonorrhea, erysipelas, hypertension, enteritis, tonsillitis, bronchitis, and dysentery (Dai et al, 2015;Liu et al, 2017;Lee et al, 2018;Wang et al, 2019). Recent researches have proved that P. tomentosa possesses various pharmacological activities, such as antibacterial, anti-inflammatory, antiphlogistic, antitussive, antiasthmatic, immunomodulatory, antioxidant, antiviral, and anticholinesterase activities (Dai et al, 2015;Liu et al, 2017;Wang et al, 2019). P. tomentosa flower polysaccharides (PTFP), which are extracted from the P. tomentosa flower, are the main water-soluble component of this flower.…”

Section: Introductionmentioning

confidence: 99%

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Paulownia tomentosa flower polysaccharide as an effective immunopotentiator to enhance immune responses for Newcastle disease vaccine in mice

et al. 2021

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To investigate the immunomodulatory activity and explore the mechanism of Paulownia tomentosa flower polysaccharides (PTFP). PTFP was orally administrated to mice for seven successive days before and after Newcastle disease vaccination. The results demonstrated that compared with the vaccine control (VC) group, PTFP enhanced the inhibition of hemagglutination assay antibody titers, promoted the antigen-specific immunoglobulin (Ig)G, IgG1, IgG2a, and IgG2b antibodies responses, enhanced proliferation of spleen T and B lymphocytes, increased the secretions of interferon-γ and interleukin-10 cytokines of spleen lymphocytes, and promoted the activation of natural killer cells. Therefore, PTFP, as an effective immunopotentiator, could induce a mixed T-helper (Th)1 and Th2 immune responses and an innate immune response.

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“…The anti-tumor immune mechanism of the body is very complex, involving a variety of immune cells and the products secreted by them. It can be divided into cellular immunity and humoral immunity as well as cytokines [9]. Cellular immunity is mainly mediated by T lymphocytes, NK cells and macrophages, and has anti-tumor effect.…”

Section: Introductionmentioning

confidence: 99%

Antigens from H22 cell mutation induced by lentinan are correlated with HCC immunoprophylaxis

Yang¹,

Li²,

Wen³

et al. 2020

Preprint

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Background Lentinan can inhibit the proliferation of many kinds of tumor cells, and some studies have shown that lentinan can inhibit the growth of tumor tissue by directly killing tumor cells. The purpose of this study was to investigate the immunoprophylaxis effect and mechanism of tumor specific antigen induced by lentinan on liver cancer in mice.Methods The immunogen was prepared which was induced by lentinan. And two different mouse H22 liver cancer models (ascites tumor and solid tumor)were established after immunogen immunized. The tumor growth and immune organ index of mice in each group were measured. In order to analyze the immune mechanism, the activity of CTL cells, activation of ADCC pathway ,T lymphocyte subsets, expression of CD4 + T,CD8 + T cells and expression of DC, and surface molecular markers CD80 and CD86 in immunized mice were analyzed. The expression of cytokines such as IFN-γ and TNF-α in serum and cell supernatant of mice in each group was tested too. Finally, the immunogen was analyzed by Liquid Chromatography-Mass Spectrometry (LC-MS), and the functional proteins were screened for further analysis.Results The liver, spleen and thymus of the mice immunized with immunogen were protected to a certain extent. In immunized mice, the proportion of CD4 + T cells increased, the proportion of CD8 + T cells decreased, the ratio of CD4 + T/CD8 + T increased, and the killing activity of T lymphocytes increased significantly. The expression of CD80 in mature DC cells of immunized mice increased and cytokines increased significantly. The results of protein mass spectrometry analysis of immunogen showed that immunogen produced protein properties that inhibit cancer.Conclusion The H22 whole-cell cleavage vaccine induced by lentinan is effective in the immunity of mouse hepatoma H22 and has development value in the future.

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A polysaccharide found in Paulownia fortunei flowers can enhance cellular and humoral immunity in chickens

Cited by 34 publications

References 35 publications

The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken

The enhanced immunological activity of Paulownia tomentosa flower polysaccharide on Newcastle disease vaccine in chicken

Paulownia tomentosa flower polysaccharide as an effective immunopotentiator to enhance immune responses for Newcastle disease vaccine in mice

Antigens from H22 cell mutation induced by lentinan are correlated with HCC immunoprophylaxis

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