A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells

Wu, Bei; Cui, Juncheng; Zhang, Chaogui; Li, Zhihong

doi:10.1016/j.ijbiomac.2012.02.023

Cited by 45 publications

(14 citation statements)

References 25 publications

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“…Due to their availability and lesser side effects, much interest has been focused on natural products in finding active compounds contributing to the anti‐cancer properties. Many studies have described the benefits of dietary nutrients and supplement such as soybeans, nuts, olive, avocado, α ‐lipoic acid, protein hydrolysate and many more in preventing different types of cancers . Furthermore, fermented Canavalia cathartica beans were recorded as having enhanced inhibitory effect on breast cancer cells MCF‐7 compared to the raw beans .…”

Section: Discussionmentioning

confidence: 99%

Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

et al. 2015

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“…It is one of the most important edible and culinary medicinal species. [7778] It is cultivated commercially for the health food market and is shown to possess a range of medicinal properties against diseases like cancer[7980] and chronic hepatitis. [81] Preclinical studies have shown it to possess anti-inflammatory effects against a range of ulcerogens.…”

Section: Dietary Agents With Anti-ibd Effectsmentioning

confidence: 99%

Dietary Agents and Phytochemicals in the Prevention and Treatment of Experimental Ulcerative Colitis

Saxena

Kaur

Hegde

et al. 2014

Journal of Traditional and Complementary Medicine

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Inflammatory bowel diseases (IBDs), consisting mainly of ulcerative colitis (UC) and Crohn's disease (CD), are important immune-mediated diseases of the gastrointestinal tract. The etiology of the disease includes environmental and genetic factors. Its management presents a constant challenge for gastroenterologists and conventional surgeon. 5-Amninosalicylates, antibiotics, steroids, and immune modulators have been used to reduce the symptoms and for maintenance of remission. Unfortunately, long-term usage of these agents has been found to lead to severe toxicities, which are deterrent to the users. Pre-clinical studies carried out in the recent past have shown that certain dietary agents, spices, oils, and dietary phytochemicals that are consumed regularly possess beneficial effects in preventing/ameliorating UC. For the first time, this review addresses the use of these dietary agents and spices in the treatment and prevention of IBD and also emphasizes on the mechanisms responsible for their effects.

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“…Many researches had focused on the fundamentally distinct anti-tumor strategies targeting the cell cycle, mainly blocking cell cycle progression. As approximately 90% of patients who suffered from osteosarcoma show metastasis at the time of initial diagnosis, many studies have focused on the molecular and/or cellular mechanisms underlying tumor formation and progression [4,5]. It was obvious that local invasion and distant migration are considered to be higher degree of malignancy in osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Wang

Lei

et al. 2016

Cell Physiol Biochem

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Background/Aims: Osteosarcoma is the second highest cause of cancer-related death in children and adolescents. Majority of osteosarcoma patients (90%) show metastasis. Previous reports revealed that osthole showed antitumor activities via induction of apoptosis and inhibition of proliferation. However, the potential effects and detailed molecular mechanisms involved remained unclear. Methods: Cell viability was analyzed by MTT assay in osteosarcoma cell lines MG-63 and SAOS-2. Cell cycle was detected by flow cytometry. The effects of migration and invasion were evaluated by wound healing assay and transwell assays. Moreover, the level of proteins expression was determined by Western blot. Results: The cell viability of MG63 and SAOS-2 were markedly inhibited by osthole in a dose- and time-dependent manner. Cell cycle was arrested and the ability of migration and invasion was obviously reduced when cells were exposed to osthole. Moreover, enzymes involved in PTEN/Akt pathway were regulated such as PTEN and p-Akt proteins. Furthermore, osthole inhibited the tumor growth in vivo. Conclusion: Our study unraveled, for the first time, the ability of osthole to suppress osteosarcoma and elucidated the regulation of PTEN/Akt pathway as a signaling mechanism for the anti-tumor action of osthole. These findings indicate that osthole may represent a novel therapeutic strategy in the treatment of osteosarcoma.

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A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells

Cited by 45 publications

References 25 publications

Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

Dietary Agents and Phytochemicals in the Prevention and Treatment of Experimental Ulcerative Colitis

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

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