A Pooled Analysis of Diagnostic Value of 99mTc-Ubiquicidin (UBI) Scintigraphy in Detection of an Infectious Process

Ostovar, Afshin; Assadi, Majid; Vahdat, Katayoun; Nabipour, Iraj; Javadi, Hamid; Eftekhari, Þ Mohammad; Assadi, Majid

doi:10.1097/rlu.0b013e3182867d56

Cited by 39 publications

(22 citation statements)

References 21 publications

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“…3,4). A pooled meta-analysis of clinical studies with 99m Tc-UBI 29-41 showed 95% sensitivity, 93% specificity and 94% accuracy in various clinical settings including prosthetic infections, diabetic foot infections, fever of unknown origin, osteomyelitis, mediastinitis, and appendicitis [55,64,65]. Due to its ability to discriminate between infection and sterile inflammation, general safety, the lack of side effects [66][67][68][69], and the successful transformation to kit formulations [59,[70][71][72], radiolabelled UBI 29-41 has been proposed as a good candidate for applications in routine imaging [4,9,61].…”

Section: Imaging Of Infections With Antimicrobial Peptidesmentioning

confidence: 99%

An update on radiotracer development for molecular imaging of bacterial infections

Welling

Hensbergen

Bunschoten

et al. 2019

Clin Transl Imaging

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Background Bacterial infections are still a major global healthcare problem. To combat the increasing antimicrobial resistance, early diagnosis of bacterial infections-including the identification of bacterial species-is needed to improve antibiotic stewardship and to help reduce the use of broad-spectrum antibiotics. To aid successful targeted antibiotic treatment, specific detection and localisation of infectious organisms is warranted. Nuclear medicine imaging approaches have been successfully used to diagnose bacterial infections and to differentiate between pathogen induced infections and sterile inflammatory processes. Aim In this comprehensive review we present an overview of recent developments in radiolabelled bacterial imaging tracers. Methods The PubMed/MEDLINE and Embase (OvidSP) literature databases were systematically searched for publications on SPECT and PET on specific imaging of bacterial using specific guidelines with MeSH-terms, truncations, and completion using cross-references. Tracers in literature that was extensively reviewed before 2016 were not included in this update. Where possible, the chemical structure of the radiolabelled compounds and clinical images were shown. Results In 219 original articles pre-clinical and clinical imaging of bacterial infection with new tracers were included. In our view, the highest translational potential lies with tracers that are specific to target the pathogens: e.g., 99m Tc-and 68 Galabelled UBI 29-41 , 99m Tc-vancomycin, m-[ 18 F]-fluoro-PABA, [methyl-11 C]-D-methionine, [ 18 F]-FDS, [ 18 F]-maltohexaose and [ 18 F]-maltotriose. An encouraging note is that some of these tracers have already been successfully evaluated in clinical settings. Conclusion This review summarises updates in tracer development for specific (pre-clinical and clinical) imaging of bacterial infections. We propsed some promising tracers that are likely to become innovative standards in the clinical setting in the near feature.

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Section: Imaging Of Infections With Antimicrobial Peptidesmentioning

confidence: 99%

An update on radiotracer development for molecular imaging of bacterial infections

Welling

Hensbergen

Bunschoten

et al. 2019

Clin Transl Imaging

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“…Ubiquicidin is also produced in activated macrophages and in colonic epithelial cells. In an analysis of the diagnostic performance of 99m Tc-ubiquicidin in infection imaging from studies published between 2004 and 2010, a pooled sensitivity and specificity of 94.5% (95% confidence interval, 91.2%-96.8%) and 92.7% (95% confidence interval, 80%-100%), respectively, were reported (28).…”

Section: Imaging Antibiotic Binding To Microbes: Radiolabeled Antimicmentioning

confidence: 99%

Metabolic Imaging of Infection

et al. 2017

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Metabolic imaging has come to occupy a prominent place in the diagnosis and management of microbial infection. Molecular probes available for infection imaging have undergone a rapid evolution starting with nonspecific agents that accumulate similarly in infection, sterile inflammation, and neoplastic tissue and then extending to more targeted probes that seek to identify specific microbial species. This focus review describes the metabolic and molecular imaging techniques currently available for clinical use in infection imaging and those that have demonstrated promising results in preclinical studies with the potential for clinical applications.

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“…Der murine anti-CD3 Antikörper Muromab bindet spezifisch an CD3 und wird als immunsupprimierendes Medikament bei organtransplantierten Patienten zur Prophylaxe einer akuten Abstoßungsreaktion und in der Therapie der Psoriasis Arthritis eingesetzt [106]. 99 Bruijnen et al (2016) untersuchten zudem mit 89 Zr-markiertem Rituximab mittels PET/CT das Therapieansprechen von Patienten mit RA auf eine Rituximab-Therapie. 89 Zr-Rituximab-PET/CT wurde vor und 24 Monate nach Beginn der Behandlung durchgeführt, quantitativ ausgewertet und mit der Anzahl an CD22-positiven B-Lymphozyten in inguinalen Lymphknoten verglichen.…”

Section: Cd3unclassified

Molekulare Entzündungsdiagnostik im 21. Jahrhundert – der Weg zu mehr Spezifität und individualisierter Medizin?

Bouter

2017

Nuklearmediziner

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ZusammenfassungDie Diagnostik entzündlicher Erkrankungen stellt nach wie vor eine große klinische Herausforderung dar. Die molekulare Bildgebung erlaubt die Darstellung eines entzündlichen Geschehens in vivo, wobei pathophysiologische Veränderungen in einer frühen Phase des Entzündungsprozesses noch vor dem Auftreten anatomischer Veränderungen detektierbar sind. Es stehen verschiedene nuklearmedizinische Tracer zur Entzündungsdiagnostik mittels Gammakamera und PET/CT mit unterschiedlicher Spezifität zur Darstellung einer Entzündung zur Verfügung. Der vorliegende Artikel befasst sich schwerpunktmäßig mit den Entwicklungen der nuklearmedizinischen Entzündungsdiagnostik in den letzten 16 Jahren. Auf dem Weg zu mehr Spezifität und Individualität in der Bildgebung akuter und chronischer Entzündungen werden erste Ergebnisse über die klinische Anwendung neue Tracer, mit ihren jeweiligen Vorzügen und Limitationen, vorgestellt.

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A Pooled Analysis of Diagnostic Value of 99mTc-Ubiquicidin (UBI) Scintigraphy in Detection of an Infectious Process

Abstract: The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.

Cited by 39 publications

References 21 publications

An update on radiotracer development for molecular imaging of bacterial infections

An update on radiotracer development for molecular imaging of bacterial infections

Metabolic Imaging of Infection

Molekulare Entzündungsdiagnostik im 21. Jahrhundert – der Weg zu mehr Spezifität und individualisierter Medizin?

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