A pooled case-only analysis of obesity and breast cancer subtype among Black women in the southeastern United States

Moore, Jared M.; Pal, Tuya; Beeghly–Fadiel, Alicia; Fadden, Mary Kay; Munro, Heather M.; Dujon, Steffie-Ann; Reid, Sonya; Tezak, Ann; Blasingame, Miaya; Ware, Jeania; Blot, William J.; Shu, Xiao‐Ou; Wang, Zheng; Sanderson, Maureen; Lipworth, Loren

doi:10.1007/s10552-021-01545-8

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Even when receiving equal treatment, AAW with TNBC experience a worse prognosis [24][25][26]28,30]. Various factors such as differences in mutational landscapes, gene expression, and tumor microenvironment contribute to the poor outcomes observed in AAW with TNBC [25,[30][31][32][33][34][35][36]. The higher prevalence of TNBC and lower survival rates in young AAW suggest the presence of race-associated molecular mechanisms in breast cancer [37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Updated Biomarkers for TNBC in African vs. Caucasian American Women

Croft,

Quintanar,

Zhang

2023

Preprint

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Introduction: Breast cancer, especially triple-negative breast cancer (TNBC), is a significant concern in the US, being the most common cancer among women and the second leading cause of cancer-related deaths. TNBC lacks crucial receptors targeted in other breast cancer types, leading to a poor prognosis and limited treatment options due to its aggressive and heterogeneous nature. Significance: African American women (AAW) with TNBC face higher mortality rates and more aggressive disease compared to Caucasian American women (CAW). Despite efforts to find biomarkers specific to AAW and CAW with TNBC, limited sample availability and data resources have been obstacles. Methods: In our study, we examined 237 candidate peptide biomarkers using publicly available data. Results: identify 23 unique prognostic biomarkers. These biomarkers accurately assess patient conditions based on race-specific gene expression patterns, holding potential to address racial disparities in TNBC treatment. Conclusion: Overall, our research sheds light on how racial genetic profiles influence TNBC prognosis and treatment efficacy. The identified prognostic biomarkers pave the way for future studies addressing TNBC racial disparities and personalized treatment approaches.

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Section: Introductionmentioning

confidence: 99%

Updated Biomarkers for TNBC in African vs. Caucasian American Women

Croft,

Quintanar,

Zhang

2023

Preprint

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Reproductive Risk Factor Patterns in Caribbean Women With Breast Cancer Across 4 Generations

Sanchez-Covarrubias,

Chery,

Barreto-Coehlo

et al. 2024

JAMA Netw Open

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ImportanceBreast cancer (BC) is commonly diagnosed among Caribbean women. Shifts in reproductive patterns modify the incidence of BC diagnosis and age at BC diagnosis in population-based studies; however, reproductive patterns in Caribbean women remain understudied.ObjectiveTo describe the temporal trends in reproductive patterns and age at BC diagnosis in Caribbean-born women.Design, Setting, and ParticipantsA cross-sectional observational study—the Caribbean Women’s Cancer Study—was conducted, with data on reproductive patterns known to affect BC risk collected in The Bahamas, Barbados, Cayman Islands, Dominica, Haiti, Jamaica, and Trinidad and Tobago. Participants were recruited prospectively. The sample included women born in Caribbean countries and diagnosed with invasive BC and/or ovarian cancer from June 1, 2010, to June 30, 2018, and was divided into 4 birth cohorts (born before 1950, 1950-1959, 1960-1969, and in or after 1970). Data were analyzed between August 1, 2023, and July 31, 2024.ExposuresReceipt of a BC diagnosis and birth in a Caribbean country.Main Outcomes and MeasuresChange in reproductive patterns between birth cohorts, including age at BC diagnosis, family history of cancer, age at first pregnancy, number of pregnancies, number of full-term pregnancies, number of siblings, age at menarche and menopause, estrogen receptor status, and germline pathogenic/likely pathogenic variants.ResultsOf 1015 participants diagnosed with BC and ovarian cancer, 995 women (mean [SD] age, 46.6 [10.8] years; 605 [81.8%] Afro-Caribbean, 98 [13.2%] East Indian, 22 [3.0%] White, and 12 [1.6%] &gt;1 race) received a diagnosis of invasive BC. Comparison from older to younger birth cohorts (presented in the order of born before 1950, 1950-1959, 1960-1969 and in or after 1970) showed an increased proportion of women experiencing menarche at age 12 years or younger (33.0% vs 47.3% vs 45.5% vs 57.9%; P &lt; .001), women with no pregnancies (6.8% vs 6.8% vs 10.5% vs 22.8%; P &lt; .001), and nulliparous women (8.6% vs 9.2% vs 13.9% vs 27.6%; P &lt; .001). Younger age at BC diagnosis was observed in women experiencing menarche at age 12 years or younger (mean [SD], 45.0 [10.5] years) vs 15 years or older (mean [SD], 49.1 [11.2] years) and in nulliparous women (mean [SD], 42.1 [11.2] years) vs 3 or more full-term pregnancies (mean [SD], 49.9 [10.6] years; P &lt; .001). For every year of first pregnancy delay, women had a 4% increased chance of being diagnosed with estrogen receptor–positive tumors (odds ratio, 1.04; 95% CI, 1.01-1.08; P = .02).Conclusions and RelevanceIn this cross-sectional study, between each 10-year birth cohort, women diagnosed with BC had a lower age at menarche, number of pregnancies, and number of full-term pregnancies. These findings suggest that interventions targeting other BC risk factors need to be implemented.

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Association of physical weight statuses defined by body mass index (BMI) with molecular subtypes of premenopausal breast cancer: a systematic review and meta-analysis

Li,

et al. 2023

Breast Cancer Res Treat

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A pooled case-only analysis of obesity and breast cancer subtype among Black women in the southeastern United States

Cited by 4 publications

References 25 publications

Updated Biomarkers for TNBC in African vs. Caucasian American Women

Updated Biomarkers for TNBC in African vs. Caucasian American Women

Reproductive Risk Factor Patterns in Caribbean Women With Breast Cancer Across 4 Generations

Association of physical weight statuses defined by body mass index (BMI) with molecular subtypes of premenopausal breast cancer: a systematic review and meta-analysis

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