A population-based case-control analysis of the association between enema and nervous system injury caused by diquat poisoning

Abstract

Objective：The objective of this study was to investigated whether enema is associated with nervous system injury caused by diquat poisoning using a population-based case-control analysis. Methods: The medical records of patients with acute diquat(DQ) poisoning admitted to the hospital from January 2018 to January 2024 were retrospectively collected. A series of symptoms of central nervous system injury occurred after DQ poisoning were defined as DQ nervous system injury, which identified as the case group in our study. The controls group were matched 1:2 on population-based without nervous system injury in DQ poisoning patients. Conditional logistic regression models were performed. Results: We identified 101 DQ poisoning patients with nervous system injury and selected 202 DQ patients without nervous system injury. DQ poisoning patients performed 2 and ≧3 enemas had ORs of nervous system injury of 3.084(95%CI 1.230, 7.734) and 4.693(95%CI 1.408, 15.645) compared with DQ poisoning patients with no enema, respectively. Further analyses were performed in various age subgroups. The ORs of conducting 2 and ≧3 enemas were dramatically higher among cases group than controls group in subgroup aged ≧60 years old (OR=10.184, 14.982 respectively). Conclusions: We concluded that enemas increased the risk of with nervous system injury caused by DQ, particularly among the elderly.