A portable electrochemical method for cocaine quantification and rapid screening of common adulterants in seized samples

Freitas, Jhonys Machado; Ramos, David; Sousa, Raquel; Paixão, Thiago R.L.C.; Santana, Mário H.P.; Muñoz, Rodrigo A.A.; Richter, Eduardo M.

doi:10.1016/j.snb.2016.12.024

Cited by 104 publications

(72 citation statements)

References 52 publications

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“…The calibration plot showed a correlation coefficient of 0.995 and recovery value of 105 % was calculated, demonstrating the feasibility of the system for the analysis of seized cocaine samples. This result obtained using SPE is similar to those obtained on boron‐doped diamond electrode and graphene‐based electrodes .…”

Section: Resultsmentioning

confidence: 59%

3D‐printed Portable Platform for Mechanized Handling and Injection of Microvolumes Coupled to Electrochemical Detection

et al. 2019

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We present a low‐cost mechanized system fabricated using fused deposition modelling 3D‐printing technology to manipulate microvolumes and perform injections on an electrochemical cell in wall‐jet configuration. As a proof‐of‐concept, the amperometric detection of paracetamol (model analyte) on a screen‐printed electrode using 0.5 μL aliquots resulted in highly reproducible responses (RSD <3 %). Moreover, handling of microliter aliquots of butylhydroxytoluene (phenolic antioxidant) and 2,2‐diphenyl‐2‐picrylhydrazyl (DPPH) to promote the radical‐scavenging reaction to determine antioxidant capacity by electrochemical detection of residual DPPH was demonstrated (time‐controlled reaction). A final application of the system was devoted to the analysis of cocaine and a common adulterant found in seized samples. The mechanized 3D‐printed analytical platform is capable to execute diverse sample preparation steps on board by handling microliter aliquots and subsequent electrochemical detection. 3D‐printing technology enabled the fabrication of a versatile and low‐cost (

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Section: Resultsmentioning

confidence: 59%

3D‐printed Portable Platform for Mechanized Handling and Injection of Microvolumes Coupled to Electrochemical Detection

et al. 2019

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“…Cocaine is an alkaloid, stimulant, with anesthetic effects used primarily as a recreational drug. Freitas and co‐authors developed a method based in batch‐injection analysis system with square‐wave voltammetric on BDD electrodes . Prior the analyses, the BDD electrode was anodically pretreated by applying +0.01 A for 1000 s in 0.12 mol L −1 Britton‐Robinson buffer solution (pH 1.6).…”

Section: Electroanalysis Of Pharmaceuticalsmentioning

confidence: 99%

Electroanalysis of Pharmaceuticals on Boron‐Doped Diamond Electrodes: A Review

et al. 2019

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diamond (BDD) electrodes possess outstanding physical, chemical, and electronic properties and have been successfully, yet in a limited way, explored in the electroanalysis of substances with therapeutic action (analgesics, antipyretics, antibiotics, anti-inflammatories, antihypertensives, antidepressants, vitamins, and others) in diverse milieus (pharmaceutical formulations, urine, serum, whole blood, surface waters, seawaters, groundwater, wastewaters, etc.). Therefore, in this Review, a broad overview of the available scientific information on recent progress and achievements of the application of bare or modified BDD electrodes to the bioanalytical and environmental detection of pharmaceutical compounds is presented. The main parameters, for example boron concentration, applied operational conditions during pretreatment, chemical and physical structure, and other influential factors on the electroanalytical BDD electrodes performance, are discussed.[a] Dr.

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“…In addition, application of new electrode materials provides improvement on sensitivity and selectivity, resulting in unique advantages for such analytical systems [6]. Glassy carbon electrodes (GCEs) [7][8][9][10][11] and boron-doped diamond electrodes (BDDEs) [12][13][14][15][16][17][18][19] were mostly used electrode materials in BIA for the determination and quantification of many compounds. Other carbon-based electrodes, such as graphite-composite electrode [20], GCE modified with multi-walled carbon nanotubes [21,22] or coated with a mercury thin film [23], as well as some metal electrodes, such as gold [24] or copper ones [25], were also successfully tested and applied.…”

Section: Introductionmentioning

confidence: 99%

Batch Injection Analysis with Amperometric Detection for DNA Biosensing Applications

2019

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In this work, batch injection analysis with the amperometric detection (BIA‐AD), employing a detection cell designed to adapt a screen‐printed carbon electrode (SPCE) was used for the first time as a robust electroanalytical system for DNA biosensing applications. The sensitive amperometric detection was used to evaluate the structural changes in double‐stranded DNA (dsDNA) after UV‐C irradiation of its solution for a given time. Batching of DNA samples was performed by precise electronic pipette microinjection of an irradiated sample aliquot onto the unmodified activated SPCE surface incorporated in the BIA‐AD system. Using the optimized experimental conditions (40 μL of 1 mg mL−1 dsDNA in a 0.1 M phosphate buffer of pH 7.4 sampled at the injection speed degree of 6 and detected at the potential of +1.5 V vs silver pseudo‐reference electrode), a time‐dependent response (gradual decrease of amperometric signal up to 58 % after 10 min of the irradiation) was found for the detection of damage to low molecular weight salmon sperm dsDNA. The advantages of this low‐dimensional and cost‐effective measuring system can be utilized not only for the quantification of DNA damage/degradation by UV irradiation, but they are also promising for studying other types of DNA interactions.

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A portable electrochemical method for cocaine quantification and rapid screening of common adulterants in seized samples

Cited by 104 publications

References 52 publications

3D‐printed Portable Platform for Mechanized Handling and Injection of Microvolumes Coupled to Electrochemical Detection

3D‐printed Portable Platform for Mechanized Handling and Injection of Microvolumes Coupled to Electrochemical Detection

Electroanalysis of Pharmaceuticals on Boron‐Doped Diamond Electrodes: A Review

Batch Injection Analysis with Amperometric Detection for DNA Biosensing Applications

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