A portable reflectometer for the rapid quantification of cutaneous haemoglobin and melanin

Feather, J. W.; Ellis, D. J.; Leslie, Gemma

doi:10.1088/0031-9155/33/6/005

Cited by 96 publications

(79 citation statements)

References 9 publications

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“…After data acquisition, the data were converted to ASCII text and exported to Microsoft Excel 2000 (Microsoft Corporation, Redmond, Washington). IHB and IOX were calculated with a modified version of methods by Feather et al [31][32] and Hagisawa et al [28]. Equations for the calculation of IHB and IOX for this study were where A is the absorption value at the specified wavelength (nanometer) in the TRS.…”

Section: Ischial Cutaneous Hemoglobin and Oxygenationmentioning

confidence: 99%

Interface pressure and cutaneous hemoglobin and oxygenation changes under ischial tuberosities during sacral nerve root stimulation in spinal cord injury

Liu

Nicholson²,

Knight³

et al. 2006

JRRD

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Abstract-Noninvasive functional magnetic stimulation (FMS)of the sacral nerve roots can activate gluteal muscles. We propose the use of sacral anterior root stimulator (SARS) implants to prevent ischial pressure ulcers in the spinal cord injury (SCI) population. In this study, we (1) investigated the acute effects of sacral FMS on ischial pressure, skin blood content, and oxygenation changes in people with SCI and demonstrated the utility of FMS as an assessment tool, and (2) showed that similar effects are possible with electrical stimulation via a SARS implant. Results indicated that sacral nerve root stimulation, either by FMS or implanted electrical stimulation, induced sufficient gluteus maximus contraction to significantly change subjects' ischial pressures and cutaneous hemoglobin and oxygenation during sitting. In addition to these beneficial acute effects, chronic stimulation via a SARS implant may build gluteal muscle bulk and prevent or reduce pressure ulcers in the SCI population.

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Section: Ischial Cutaneous Hemoglobin and Oxygenationmentioning

confidence: 99%

Interface pressure and cutaneous hemoglobin and oxygenation changes under ischial tuberosities during sacral nerve root stimulation in spinal cord injury

Liu

Nicholson²,

Knight³

et al. 2006

JRRD

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show abstract

“…We also investigated the correlation between oxidative DNA damage and digitalized skin pigmentation level by using a reflectance spectrophotometer in each subject (12)(13)(14). On the basis of our epidemiologic results, we experimentally examined the effect of ultraviolet B (UVB) light irradiation on urinary 8-OHdG levels in hairless mice (HL-mice).…”

Section: Introductionmentioning

confidence: 99%

Sunlight Exposure–Mediated DNA Damage in Young Adults

Kato

Iida

Goto

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The LBS probe consists of a fiber bundle for illumination and an avalanche photodiode module placed 22 mm from the fiber bundle for detection. Feather et al 9 reported a portable diffuse reflectometer that uses nine LEDs at three visible wavelengths to illuminate skin and a photodiode to collect diffusely reflected light, through a 7-mm aperture. The LBS has a sensing depth over 1 cm, but is difficult to multiplex into a spectral imaging device because of the size of the device.…”

mentioning

confidence: 99%

Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

Kuech

et al. 2008

J. Biomed. Opt.

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Abstract.A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0± 5.6 and 6.1± 4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo. © UV-visible diffuse reflectance spectroscopy ͑UV-VIS DRS͒ is sensitive to the absorption and scattering properties of biological molecules in tissue and thus can be used as a tool for quantitative tissue physiology in vivo. One major absorber of light in mucosal tissue in the visible range is hemoglobin ͑Hb͒, which shows distinctive, wavelength-dependent absorbance characteristics depending on its concentration and oxygenation. Tissue scattering is sensitive to the size and density of cellular structures such as nuclei and mitochondria. Thus, DRS of tissues can quantify changes in oxygenation, blood volume and alterations in cellular density and morphology. Some potential clinical applications of UV-VIS DRS include monitoring of tissue oxygenation, 1 precancer and cancer detection, 2,3 intraoperative tumor margin assessment, 4 and assessing tumor response to cancer therapy. 1Our group has developed a fiber optic DRS system 5 and a fast inverse Monte Carlo ͑MC͒ model of reflectance 6 to nondestructively and rapidly quantify tissue absorption and scattering properties. The system consists of a 450-W xenon lamp, a monochromator, a fiber optic probe, an imaging spectrograph, and a CCD camera. Previously published studies by our group 7 show that this technology is capable of quantifying breast tissue physiological and morphological properties, and that these quantities can be used to discern between malignant and non-malignant tissues with sensitivities and specificities exceeding 80%. Although this technology coupled with the MC model is a robust toolbox for quantifying tissue optical properties, this system suffers from several drawbacks similar to other spectrometers. First, optical fibers when used for detection, collect a relatively small portion of the remitted signal, thus high-quantum-efficiency, low-noise detectors are required to detect the signal, particularly in the UV-blue spectral region. Optical-fiber-based detection, while reasonable for single-point sampling, is unwieldy and expensive...

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A portable reflectometer for the rapid quantification of cutaneous haemoglobin and melanin

Cited by 96 publications

References 9 publications

Interface pressure and cutaneous hemoglobin and oxygenation changes under ischial tuberosities during sacral nerve root stimulation in spinal cord injury

Interface pressure and cutaneous hemoglobin and oxygenation changes under ischial tuberosities during sacral nerve root stimulation in spinal cord injury

Sunlight Exposure–Mediated DNA Damage in Young Adults

Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

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