A possible predictive marker of progression for hepatocellular carcinoma

Stasio, Michele Di; Volpe, Maria Grazia; Colonna, Giovanni; Nazzaro, M.; Polimeno, Miriam; Scala, Stefania; Castello, Giuseppe; Costantini, Susan

doi:10.3892/ol.2011.378

Cited by 22 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several clinical studies have provided evidence indicating that lower SBP1 levels are associated with worse prognosis of the cancers of lung, colorectal, stomach, and liver [13,14,19,22,23,26,27]. Our studies have demonstrated an association between SBP1 expression, as assayed by tissue microarray (TMA), with disease-free survival as well as overall survival among stage III colorectal cancer patients using Kaplan–Meier analysis [14].…”

Section: Introductionmentioning

confidence: 74%

See 1 more Smart Citation

Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome

Yang

Diamond

2013

Biomark Res

View full text Add to dashboard Cite

Selenium is a trace element that plays a critical role in physiological processes and cancer prevention, whose functions may be through its effects on selenium-containing proteins. Selenium-binding protein 1 (SBP1) is a member of an unusual class of selenium-containing proteins that may function as a tumor suppressor in multiple cancer types and whose levels have been shown to be lower in cancers as compared to corresponding normal tissues. This review is intended to summarize recent advances in gaining an understanding of the significance of SBP1 in carcinogenesis, and suggest that SBP1 could be developed as a potential biomarker for cancer progression and prognosis.

show abstract

Section: Introductionmentioning

confidence: 74%

“…Subsequently, significantly reduced levels of SBP1 in tumors as compared to the corresponding normal tissue has now been documented in cancers of the ovary, lung, esophagus, colon, stomach, liver and in uterine leiomyoma [13,14,18–27]. Reduced expression of SBP1 is also associated with tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome

Yang

Diamond

2013

Biomark Res

View full text Add to dashboard Cite

show abstract

“…Actually, antioxidant properties of selenoproteins are relevant in protection from cancers [25]. Evidence from animal models and primary human hepatocytes implicate Se in liver cancer development [1–4], whereas progressive cancer grade were correlated with decreasing Se concentrations in HCC tumor tissues [26]. Nataliya stated that in the case of HCC patients with low Se levels, Se supplementation could be considered for chemoprevention [2].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the correlation between selenium and incidence of hepatocellular carcinoma

Zhang

Bi²,

Liu

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method. Heterogeneity was assessed by using the I2 index. Publication bias was evaluated by Begg's Test analysis. Pooled analysis indicated that patients with HCC had lower Se levels than the healthy controls [standardized mean difference (SMD)= −1.08, 95% confidence intercal (CI) = (−0.136, −0.08), P < 0.001]. Further subgroup analysis showed this effect to be independent of the study design, race or sample collection. In conclusion, this meta-analysis suggested an inverse correlation between Se level and the risk of HCC in humans patients.

show abstract

“…This protein is able to incorporate exogenously administered radioactive (75Se)-sodium selenite in the liver in vivo (Di Stasio et al, 2011;Raucci et al, 2011). We have recently evaluated the expression of SELENBP1 and selenium in tissue samples of HCC patients evidencing that SELENBP1, as well as selenium, Fig.…”

Section: Down-regulated Genesmentioning

confidence: 99%